Production and characterization of carboxymethyl pullulan and sodium alginate membrane, incorporated with phytotherapeutic actives from ethanolic extract of Dillenia indica for healing of cutaneous wounds

• Grant number: 23/07968-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2024
• End date: December 31, 2024
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Simone de Fátima Medeiros Sampaio
• Grantee: Lilian Rodrigues Lopes
• Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil

Abstract

With the significant increase in studies related to sustainability and reuse of raw materials, which are often discarded and unused, the proposal is to use extracts from plants and vegetables that are not used or are underused. In this study, the objective is to produce a membrane made of carboxymethyl pullulan (CMPull) and sodium alginate (SA) incorporated with ethanolic extract of Dillenia Indica for the release of phytotherapeutic active ingredients for the healing of apparent wounds. The membranes will be produced by the solvent evaporation method. (foundry). The ethanolic extract of Dillenia indica has already been obtained and characterized in the previous study carried out by the student, as well as carboxymethyl pullulan has already been synthesized and characterized by 1H NMR and FTIR-ATR techniques. This summary and characterization of carboxymethyl pullulan and ethanolic protection of Dillenia indica was carried out in a scientific initiation project, PUB-USP called ``Use of Dillenia indica components for production of membranes for controlled release`` in the period of 08/01/ 2022 until 08/31/2023. The membranes produced will be specified and tested using different techniques, in accordance with the technical standards for characterizing wound healing dressings, which are found in Title 21 of the United States Code of Federal Regulations (21 CFR). If we have the expected result, we will have a 100% biodegradable and low-cost membrane, which can be used for biodegradable dressings in the pharmaceutical industry.