| Grant number: | 23/08249-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | May 01, 2024 |
| End date: | October 15, 2026 |
| Field of knowledge: | Health Sciences - Physical Education |
| Principal Investigator: | Carlos Roberto Bueno Júnior |
| Grantee: | Guilherme da Silva Rodrigues |
| Host Institution: | Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| Associated research grant: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health, AP.TEM |
| Associated scholarship(s): | 24/17705-1 - EPIGENETIC COMPARISON OF CELL TYPE PROPORTION BETWEEN PRE-MENOPAUSE AND POST-MENOPAUSE WOMEN IN EPIGENOME-WIDE ASSOCIATION STUDIES, BE.EP.DR |
Abstract The literature has shown associations with low muscle mass as an independent risk factor for increased mortality in older men and women. Drawing a predictive score for women for strength improvement levels can be advantageous since participants who present unsatisfactory results may need greater attention. Notably, for complex phenotypes, such as strength and cardiorespiratory capacity, the literature shows that each gene appears to be of little relevance for these investigations. This present work has four objectives: to trace the baseline predictor score of the participants with the highest strength results; to perform the predictive score of participants subdivided into responders/non-responders after 14 weeks of combined training; to analyze the epigenetic differences of the participants in objective one and two, investigating biomarkers; to compare the effect of 14 weeks of combined training on responders/non-responders on biochemical variables, metal concentration, global health, motor skills, anthropometry, blood pressure, and epigenetic clock. We will use two Illumina bead chips to experiment. The first will be the Infinium Global Screening Array-24 v1.0 BeadChip, which will investigate 640 thousand genetic variants. The second will be the Infinium Methylation BeadChip 850k from Illumina to investigate the methylation targets. It should be noted that this bead chip will be performed at three different times during training. The evaluations will be carried out: at the beginning of the collection, after seven weeks of training, and after 14 weeks. Combined training will be performed for 14 weeks, three times a week, divided into 30 minutes of aerobics and 30 minutes of strength training. The methylation data will be analyzed using the Bioconductor ChAMP package with the RStudio software (version 4.0.2). In contrast, the genotyping data will be processed using PLINK (version 1.9), and later machine learning tools will be used to recognize the scores. Predictors for objectives number one and two. The other collected data will be processed through RStudio (version: 4.2.1). (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |