Synthesis of five-membered N-heterocycles employing green methods

• Grant number: 24/05518-2
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: July 01, 2024
• End date: May 31, 2028
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Arlene Gonçalves Corrêa
• Grantee: Alice Karoline de Almeida Martinez
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 21/12394-0 - Sustainable synthetic methods employing catalysis, benign solvents, safer reagents, and bio-renewable feedstock, AP.TEM

Abstract

This work aims to synthesize five-membered N-heterocycles, using greener methods, such as multicomponent reactions and one-pot reactions, in addition to studying gamma lactams through the Ugi reaction. The evaluation of enantioselectivity in Ugi, Michael and aziridination reactions with chiral organocatalysts will also be addressed.In parallel, the asymmetric synthesis of (-)-clausenamide will be carried out and, finally, the biological activity of the synthesized compounds will be evaluated.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINEZ, ALICE K. DE A.; MOURAO, PENINA S.; CORREA, ARLENE G.. A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds. Synlett, v. N/A, p. 9-pg., 2025-03-12. (24/05518-2, 21/12394-0)

VIDAL, HERIKA D. A.; NUNES, PAULO S. G.; MARTINEZ, ALICE K. A.; JANUARIO, MARCELO A. P.; SANTIAGO, PEDRO H. O.; ELLENA, JAVIER; CORREA, ARLENE G.. Diastereoselective Synthesis of Highly Functionalized γ-Lactams via Ugi Reaction/Michael Addition. CHEMISTRY-AN ASIAN JOURNAL, v. N/A, p. 7-pg., 2024-11-09. (19/06555-0, 17/15850-0, 24/05518-2, 21/12394-0, 21/10066-5)