Conventional synthesis of heterocycle cores for the development of a microscale synthesis platform

• Grant number: 24/09495-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2024
• End date: October 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Daniel Gedder Silva
• Grantee: Tiago Henrique Corrêa da Silva
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 23/11804-5 - Combining Microscale Parallel Synthesis (MPS) and Medium-Throughput Screening (MTS) for Accelerated Hit-to-lead Optimization of Anti-Infective Agents., AP.JP

Abstract

The scientific initiation project will support the main Fapesp Young Investigator Grant (2023/11804-5). The aim of the project is to synthesize the starting materials necessary for the development of the microscale parallel synthesis method. Therefore, the project will enable the learning of techniques for organic synthesis, purification and the desing of bioactive compounds, as well as the use of techniques relevant to academic training, such as infrared spectroscopy (IR), mass spectrometry (MS) and nuclear magnetic resonance (NMR) and analytical methods such as HPLC and LCMS. In addition, based on biological results, carried out through partnerships with our collaborators at the University of Antwerp, the student will learn how to build SAR studies.