Photocrosslinkable rotational molding as a novel strategy to develop 3Dshapable biomaterials

• Grant number: 24/21677-3
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 30, 2025
• End date: February 18, 2026
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Willian Fernando Zambuzzi
• Grantee: Júlia Ferreira de Moraes
• Supervisor: Joao Manuel Marques Rodrigues
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Institution abroad: Universidade de Aveiro (UA), Portugal
• Associated to the scholarship: 23/14547-3 - Construction of biomimetic units from platelet-rich plasma associated with chaotic fluid using static mixers: prospects for new biotechnological processes for bone tissue regeneration., BP.MS

Abstract

This project explores an innovative approach to developing 3D-shapeable biomaterials for bone tissue engineering using photocrosslinkable rotational molding. Given the essential role of bone tissue in providing structural support and protection, regeneration is often necessary regeneration after injury. Biomaterials offer promising scaffolding solutions to support and enhance this regenerative process. Leveraging Gelatin Methacryloyl (GelMA) as the biomaterial base, this research aims to develop a customizable, biocompatible cryogel scaffold that emulates the extracellular matrix, supporting cellular adhesion, proliferation, and nutrient diffusion. The project employs a novel rotational molding technique to fabricate GelMA-based cryogels with controlled porosity and enhanced mechanical properties tailored for bone regeneration. The study will encompass the synthesis and characterization of GelMA cryogels, incorporating advanced methods such as ¹H NMR spectroscopy for structural analysis and microscopic techniques for 3D porosity visualization. Conducted in collaboration with CICECO - Aveiro Institute of Materials, which provides state-of-the-art facilities and interdisciplinary expertise in biomimetic materials, this research aims to advance the field of biomaterial scaffolds for clinical applications in regenerative medicine. (AU)