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Influence of cyclooxygenase 2 enzyme on autogenous bone grafts repair: histomorphometric analysis in rabbits

Grant number: 09/14989-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2009
Effective date (End): November 30, 2010
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Mariza Akemi Matsumoto
Grantee:Claudia Cristina Biguetti
Home Institution: Centro de Ciências Biológicas e Profissões da Saúde. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil


Reconstruction of atrophic areas of edentulous ridge aiming oral rehabilitation using endosseous implants can be performed using a number of techniques and materials, although autogenous bone graft is still considered the "gold standard" for these procedures. In this way, endochondral and intramembranous bones can be used. During a long period it was thought that the only difference between mature bone tissues from both embryologic origins was the cortical and trabecular bone proportion. Nowadays, researches point out molecular differences between them, as in the expression of morphogenetic bone proteins and metalloproteinases that could possibly explain the differences in revascularization and bone grafts incorporation. In order to collaborate with the investigation, the present study aims to evaluate the influence of inhibition of cyclooxygenase 2 enzime in the process of intramembranous and endochondral autogenous bone grafts incorporation. Thirty male New Zealand rabbits will undergo surgical procedure to receive autogenous bone grafts from the calvaria and iliac crest in their calvarias. The animals will be randomly distributed into two groups: Group 1) Negative control, animals receiving water, Group 2) Animals treated with etoricoxib (Arcoxia®), orally. Animals of Group 2 will receive the drug etoricoxib in the proportion of 6 mg/Kg, beginning its administration one week before the surgical procedure, continuing with the same dose every 24 hours, until the date of sacrifice, as follows: a - 7 days; b - 14 days; c - 30 days, when macroscopical, microscopical morphologic analysis, and histomorphometry of grafted areas will be analyzed. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORESCHI, EDUARDO; BIGUETTI, CLAUDIA CRISTINA; COMPARIM, ELISTON; HOLGADO, LEANDRO DE ANDRADE; RIBEIRO-JUNIOR, PAULO DOMINGOS; NARY-FILHO, HUGO; MATSUMOTO, MARIZA AKEMI. Cyclooxygenase-2 inhibition does not impair block bone grafts healing in rabbit model. Journal of Molecular Histology, v. 44, n. 6, p. 723-731, DEC 2013. Web of Science Citations: 5.
BIGUETTI, CLAUDIA CRISTINA; MARQUARDT FILHO, EMILIO JOSE; HOLGADO, LEANDRO DE ANDRADE; CAVIQUIOLI, GUSTAVO; MORESCHI, EDUARDO; COMPARIN, ELISTON; MATSUMOTO, MARIZA AKEMI. Effect of low-level laser therapy on intramembranous and endochondral autogenous bone grafts healing. MICROSCOPY RESEARCH AND TECHNIQUE, v. 75, n. 9, p. 1237-1244, SEP 2012. Web of Science Citations: 3.

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