EVALUATION OF ARTIN M GEL ON WOUND HEALING IN RAT PALATAL MUCOSA.

• Grant number: 09/16955-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2010
• End date: April 30, 2011
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Joni Augusto Cirelli
• Grantee: Pedro César Garcia Gonçalves
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Artin M, a lectin from Artocarpus integrifolia seeds, has been shown to accelerate the process of wound healing on burn injuries and corneal epithelial lesions in rabbits.The aim of this study is to evaluate the effects of Artin M on wound healing in rat palatal mucosa.Seventy-two rats will be divided into three groups according to one of the treatment assigned: C - Control (non-treated), A - Artin M, and V - Vehicle. A 4mm full thickness wound will be surgically created on palatal mucosa of each animal. Eight animals per group will be sacrificed in each time point of the 3, 5, and 7 days post surgery. Maxilla biopsy will be taken to perform: 1- histology analysis: to evaluate area of reepithelization, morphology of granulation tissue, the number of inflammatory cells, maturation of the collagen fibers and neovascularization. 2-Immunohistochemistry analysis: immunostaing for bFGF.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KIM, YEON J.; CARVALHO, FERNANDA C.; SOUZA, JOAO A. C.; GONCALVES, PEDRO C. G.; NOGUEIRA, ANDRESSA V. B.; SPOLIDORIO, LUIS C.; ROQUE-BARREIRA, MARIA C.; CIRELLI, JONI A.. Topical application of the lectin Artin M accelerates wound healing in rat oral mucosa by enhancing TGF-beta and VEGF production. WOUND REPAIR AND REGENERATION, v. 21, n. 3, p. 456-463, MAY-JUN 2013. (09/16432-1, 06/60642-2, 09/16955-4)