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Identification of signaling pathways related to predisposition for non syndromic cleft lip and/or palate

Grant number: 10/02245-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Maria Rita dos Santos e Passos Bueno
Grantee:Lucas Alvizi Cruz
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:98/14254-2 - The Human Genome Research Center, AP.CEPID


Non syndromic cleft lip and/or palate (NS CL/P) are the most common craniofacial anomalies, with mundial penetrance estimated in 1 affected for 1000 livebirths. These malformation are caracterized by a large clinical variability and result of genetics and enviromental factors matches. Studies have shown a great number of envolved genes in NS CL/P. The malformation etiology counts a precise expression regulation of these genes in the craniofacial development, so when they are disregulated the NS CL/P is possible to occur. With the intention of identify and validate candidates genes in the malformation, this project aims analyze the gene expression of dental pulp mesenchimal stem cells of NS CL/P patients, to analyze signaling pathways, in comparison to controlls.