Investigation of interaction processes involving molecular recognition of DNA and polycations/guanidinium compounds by using calorimetric techniques and dynamic light scattering measurements

• Grant number: 10/00528-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2010
• End date: February 29, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Watson Loh
• Grantee: Renata Mello Giona
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This study aims at investigating the nature of the interactino of plasmidic DNA with:i) block copolymers of neutral-cationic monomers,ii) cationic dendrimers;iii) guanidinium compounds that mimick nucleases.For this purpose, thermodynamic parameters for these interactions will be evaluated by using isothermal titration and high-sensitivity differential scanning calorimetry, as well as dynamic light scattering measurements.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIONA, RENATA MELLO; VITORAZI, LETICIA; LOH, WATSON. Assessing the Contribution of the Neutral Blocks in DNA/Block-Copolymer Polyplexes: Poly(acrylamide) vs. Poly(ethylene Oxide). Molecules, v. 28, n. 1, p. 16-pg., 2023-01-01. (10/00528-7, 21/12071-6, 15/25406-5)