Short chain fatty acid, a metabolism product from gut microbiota, protect from acute kidney injury.

Author(s)

Vinicius de Andrade Oliveira

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2014-12-05

Examining board members

Niels Olsen Saraiva Câmara; José Carlos Farias Alves Filho; Mirian Aparecida Boim; William Tadeu Lara Festuccia; Clarice Kazue Fujihara

• Advisor: Niels Olsen Saraiva Câmara

Abstract

Short-Chain Fatty Acids (SCFA) are produced by the intestinal microbiota and have anti-inflammatory and histone deacetylases inhibitors properties. Acute kidney injury (AKI) is characterized by renal inflammation that may impair kidney function. This project evaluated whether treatment with SCFA inflammatory impacts the outcomes of AKI in mice. It was observed that treatment with SCFA protected the AKI. This improvement was associated with less inflammation and lower apoptosis rate. In addition, treatment with acetate decreased the activity of histone deacetylase. Giving bacteria producing acetate, was also observed protection from AKI, along with a lower systemic inflammation. This protection of the AGCC in AKI was also observed in sepsis model. In vitro, SCFA treatment modulated both immune cells and renal cells under hypoxia and inflammatory stimuli. SCFA modulate inflammatory processes in the kidney via epigenetic actions or not, may be a promising tool in the protection of the AKI. (AU)

• FAPESP's process: 11/01016-2 - Short Chain Fatty Acid as modulators of the inflammatory response in chronic and acute experimental kidney injuries
• Grantee: Vinicius de Andrade Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate