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| Author(s): |
André Luiz Reis Rangel
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Guaratinguetá. 2017-07-18. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Engenharia. Guaratinguetá |
| Defense date: | 2017-06-30 |
| Advisor: | Ana Paula Rosifini Alves Claro |
| Abstract | |
The purpose of this study was to obtain antibacterial surfaces on Ti15Mo alloy from TiO2 nanotubes growth associated with polymeric films. Ti15Mo alloy was obtained in arc melting furnace under argon atmosphere. Ingots were subjected to heat treatment and then cold worked. After TiO2 nanotubes growth by anodic oxidation samples were divided in two groups for different depositions technique: UV grafting with NaSS and plasma enhanced chemical vapor deposition (PECVD) with chlorhexidine incorporation. The anodized surfaces were characterized with scanning electron microscopy, contact angle measurements, x-rays diffraction and x-ray photoelectron spectroscopy. The surfaces covered with polymers were assessed for wettability, chemical composition by Fourier transform InfraRed spectroscopy and polymer deposition rate. All surfaces were subjected to cells culture essays to evaluate its in vitro response. The anodic oxidation was able to create a homogeneous TiO2 nanotubes layer for different voltages and both physical and chemical methods were efficient to incorporate polymers over its surfaces. Neither nanotubes or polymers coatings presented cytotoxic effect, in the other hand surfaces with chlorhexidine were responsible for cells death. PolyNass covered surfaces showed better cells proliferation, morphology and adhesion, in addition, osteoblast differentiation essays confirmed high alkaline phosphatase activity and Calcium/Phosphate deposition over these samples. (AU) | |