Multicentric clinicopathologic study of adenomatoid odontogenic tumors

Author(s)

Ana Luiza Oliveira Corrêa Roza

• Document type: Master's Dissertation
• Press: Piracicaba, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba
• Defense date: 0000-00-00

Examining board members

Pablo Agustin Vargas; Bruno Augusto Benevenuto de Andrade; Jacks Jorge Junior

• Advisor: Pablo Agustin Vargas

Abstract

Adenomatoid odontogenic tumor (AOT) is an uncommon benign tumor that commonly appears pericoronally related to an unerupted maxillary canine in female patients in the second decade of life, containing radiopaque foci. The aim of this study was to report the clinicopathologic features of 105 new cases of adenomatoid odontogenic tumor (AOT) from Brazil, Guatemala, Mexico, and South Africa. Clinical and radiographic data were collected from records of five Oral Pathology Laboratories and all cases were microscopically reviewed. The series included 36 cases (34.2%) from South Africa, 33 cases (31.4%) from Brazil, 23 cases (21.9%) from Mexico, and 13 cases (12.3%) from Guatemala. Seventy-two patients (68.5%) were female and 33 patients (31.4%) were male, with an average age of 19.2 years. Tumors predominantly affected the anterior maxilla (48.5%), followed by the anterior mandible (29.5%), posterior mandible (15.2%), and posterior maxilla (6.6%). Sixty-three tumors (63.6%) were follicular, thirty-four (34.3%) were extra-follicular, and two (2%) were peripheral. Most cases caused considerable cortical expansion, with average size of 3.4 cm. Microscopically, most cases showed rosette-like and duct-like structures. This is one of the largest series of AOT reported in the literature, the first multicenter study involving populations from Latin America and South Africa. A fifth of the present cases affected the posterior regions of the gnathic bones, demonstrating larger size when compared to other populations (AU)

• FAPESP's process: 19/02539-0 - Multicentric clinicopathological and proteomic study of adenomatoid odontogenic tumors
• Grantee: Ana Luiza Oliveira Corrêa Roza
• Support Opportunities: Scholarships in Brazil - Master