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| Author(s): |
Renata Antunes Estaiano de Rezende
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia de Alimentos |
| Defense date: | 2018-11-23 |
| Examining board members: |
Marta Cristina Teixeira Duarte;
Dirce Yorika Kabuki;
Helenice de Souza Spinosa;
Roberson Sakabe;
Roger Wagner
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| Advisor: | Marta Cristina Teixeira Duarte |
| Abstract | |
The use of antimicrobials is the main treatment for the control of bacterioses in fish and, consequently, their wide use leads to the development and selection of resistant bacteria, which can cause the contamination of other animals and man. In addition, the lack of specific national legislation on the regulation of veterinary medicinal products for use in aquaculture, as well as the evident need for the use of this resource in the treatment of diseases, has led the fish farmer to use antimicrobial drugs available on the market for other animal species. Social pressure to reduce the use of antimicrobials in fish farming has encouraged the search for other substances to improve production, ensure consumer safety and not cause environmental damage. In this context, volatile oils have received great attention as an alternative to the use of synthetic molecules. The antimicrobial activity of volatile oils has been known for years and its mechanism of action is generally the same as traditional antimicrobials, but there is no evidence of bacterial resistance. In view of the problem of development of bacterial resistance, it is urgent to establish rules for the rational use of antibiotics and the use of alternative therapies for the control of these bacterioses. The administration of volatile oils via feed requires protection against losses by volatilization, oxidation, reduction and rearrangement reactions, which is usually achieved through the process of transporting the oils in the presence of carrier polymers. Thus, the antibacterial activity of 71 volatile oils was evaluated between those obtained experimentally from species belonging to the Collection of Medicinal and Aromatic Plants - CPMA, from CPQBA - UNICAMP and those acquired from the trade, being these native and exotic. The results of this demonstrate work that it was possible to develop a fat diet with natural product based volatile oils from aromatic species (thyme, red thyme and rosemary pepper) effective against Streptococcus agalactiae, Flavobacterium columnare and Aeromonas hydrophila, which may be administered simple and effective way. The results of the in vivo tests with Aeromonas hydrophila challenged Tilapia (Phase I and Phase II) presented evidence that the levels of the substances administered to the animals via the diet show increase in the total leukocytes of the animals and no toxicity, thus suggesting an increase in the immune response from the use of a safe and non-toxic product. The development of these therapeutic alternatives in fish farming has an innovative character and provides reduction in the damages related to the lack of quality, besides reducing the indiscriminate use of antimicrobials and the environmental impact (AU) | |
| FAPESP's process: | 13/11981-2 - EVALUATION OF VOLATILE OILS AS ANTIBACTERIALS DESIGNED TO PISCICULTURE AND ADMINISTRED IN FEED. |
| Grantee: | Renata Antunes Estaiano de Rezende |
| Support Opportunities: | Scholarships in Brazil - Doctorate |