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Physiological and molecular responses of three models of running training with equalized loads in Wistar rats

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Author(s):
Carlos Dellavechia de Carvalho
Total Authors: 1
Document type: Master's Dissertation
Press: Ribeirão Preto.
Institution: Universidade de São Paulo (USP). Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP)
Defense date:
Examining board members:
Marcelo Papoti; Fúlvia de Barros Manchado Gobatto; Camila de Moraes; Rafael Rossi Valentim
Advisor: Marcelo Papoti
Abstract

Few studies analyzed the physiological responses from the manipulation of the variables volume and intensity with equalization of loads. The aim of the present study was to investigate the physiological and molecular responses of rats, submitted to three acute and chronic running training models, with different relations between volume and intensity, but with similar loads. We verified the acute responses (Study 1) of three acute running training sessions: GZ1 (n = 24; intensity below the anaerobic threshold (AnT) obtained in incremental test; volume = 43min, intensity = 70% AnT); GZ2 (n = 24; AnT intensity; volume = 31min, intensity = 100% AnT) and GZ3 (n = 24; above AnT efforts; volume = 25min, intensity = 120.4% AnT). The animals in this experiment were subdivided into euthanized immediately (n = 6), 6 (n = 6), 12 (n = 6) and 24 (n = 6) hours after the physical exercise session. We also checked the adaptations (Study 2) of 5-week training programs with weekly frequency of three sessions based on the same sessions (Z1, Z2 and Z3). Results from Study 1 showed muscle glycogen supercompensation between 6 and 12 after exercise and 24 after in the liver. Study 2 showed that 5 weeks of treadmill running training based on intensity zones 1, 2, and 3 improved performance and increased glycogen concentrations in the soleus muscle. In both experiments we did not observe changes in the signaling pathways from the oxidative pathway proteins analysis. From the results of studies 1 and 2, we conclude that intensity modulation in treadmill running exercise does not change the kinetics of biomolecular physiological variables regarding acute responses and chronic adaptations, since the loads are equalized. (AU)

FAPESP's process: 17/04445-8 - Physiological and molecular responses of three models of running training with equalized loads in wistar rats
Grantee:Carlos Dellavechia de Carvalho
Support Opportunities: Scholarships in Brazil - Master