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| Author(s): |
Daniele Silvano Gonçalves
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Botucatu. 2016-02-29. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu |
| Defense date: | 2016-02-19 |
| Advisor: | Regina Kiomi Takahira |
| Abstract | |
Chronic kidney disease (CKD) affects mostly older dogs and its main characteristic is the irreversible loss of kidney function. CKD in dogs promotes serious metabolic alterations, often characterized by azotemia, hypoalbuminemia and non-regenerative anemia. Azotemia and uremia predispose the hemostatic abnormalities that can lead to hemorrhagic cases. In addition to platelet dysfunction, deficiency of natural anticoagulants and reduced fibrinolysis are factors that predispose to thromboembolism. This work aims to evaluate the possible bleeding or thrombotic tendencies in dogs with CKD. 20 healthy dogs were selected (control group) with tests within normal limits and 17 dogs with CKD in stages III or IV classified according to IRIS and urine protein to creatinine ratio greater than one (CKD group). Blood samples for the realization of thromboelastometry (TEM), platelet aggregation, prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen concentration were collected at one time for both groups after the inclusion criteria had been confirmed. Statistical analysis performed according to the distribution of the variable at the 5% level of significance. In the present study, we observed a state of hypercoagulable blood in dogs with CKD. In TEM with the extrinsic pathway activator, there was shortening of the clotting time and clot formation time, increasing the alpha angle and the maximum clot firmness, and reducing the maximum lysis in dogs with CKD compared to control animals. Prothrombin time also had lower results in the CKD group. In addition, the fibrinogen level was higher in this group. Platelet aggregation did not differ between groups. The joint interpretation of the results leads us to conclude that dogs with CKD have a thrombosis toward predisposition, but the platelets do not seem to play an important role in this process. (AU) | |
| FAPESP's process: | 14/02516-7 - Evaluation of hemorrhagic and thromboembolic disorders in dogs with chronic kidney disease |
| Grantee: | Daniele Silvano Gonçalves |
| Support Opportunities: | Scholarships in Brazil - Master |