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| Author(s): |
Murilo Catelani Ferraz
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Araçatuba. 2022-03-08. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba |
| Defense date: | 2022-02-21 |
| Advisor: | Paulo César Ciarlini |
| Abstract | |
The consumption of cola drinks (CD) induces obesity in rats and its effect is prevented by mate tea (MT). Obesity and caffeine present in CD and MT may contribute to hyperhomocysteinemia (HHcy) and consequent systemic oxidative stress (SOS) and kidney disease (KD). With this in mind, the aim of this work was to answer the following questions: Does obesity and the consumption of caffeine present in mate and cola tea increase the plasma concentration of homocysteine in rats? Does hyperhomocysteinemia contribute to systemic oxidative stress and kidney damage? Thus, a randomized and blind study was carried out with 90 Wistar treated for 120 days with and without CR, decaffeinated or in natura CM. The plasma concentration of homocysteine (Hcy) in the obese group was compared to the others and associated with indicators of KD (plasma creatinine, urea and symmetrical dimethylarginine, density, urinary microalbumin and calcium) and SOS (albumin, uric acid, total bilirubin, lipid peroxidation, total antioxidant capacity and total oxidant concentration). Differences between groups were calculated by ANOVA + Tukey's post-test. The association between HHcy and DR and EOS markers was quantified by Pearson's r coefficient, odds ratio and Fisher's test (GraphPad Prism, v.5.1). Caffeine from CM in natura caused a slight increase in Hcy. HHcy confirmed in obese rats decreased with consumption of decaffeinated or in natura CM. We observed a positive correlation between HHcy, lipid peroxidation and microalbuminuria, with a 6-fold higher relative risk of HHcy occurrence in obese rats and a 3-fold higher relative risk of microalbuminuria in HHcy rats. HHcy occurs in obese rats and is associated with EOS and DR. Decaffeinated CM was more effective than its in natura caffeinated form in preventing HHcy, EOS and kidney injury. (AU) | |
| FAPESP's process: | 19/22881-5 - Effectiveness of decaffeinated mate tea (Ilex paraguariensis) in preventing obesity-associated hyperhomocysteinemia and caffeine consumption in Wistar rats |
| Grantee: | Murilo Catelani Ferraz |
| Support Opportunities: | Scholarships in Brazil - Master |