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| Author(s): |
Fernando Augusto Peres
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2018-02-06 |
| Examining board members: |
Simone Appenzeller;
Andre de Souza Cavalcanti;
Fabiano Reis;
Jozélio Freire de Carvalho;
Sergio San Juan Dertkigil
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| Advisor: | Lilian Tereza Lavras Costallat; Simone Appenzeller |
| Abstract | |
Objective: To evaluate olfactory function in SLE compared to healthy individuals during the 2-year follow-up, and to determine the role of Anti-P and volume reduction of limbic structures in the occurrence of smell abnormalities. Material and Method: This is an observational, longitudinal, study with a control group. We evaluated the olfactory function, the volume of the structures of the lithic system (amygdala and hippocampus), and collected blood for anti-P dosage every year for 2 years for all patients. The included controls were submitted to the same tests and tests in two evaluations. Results: We included 95 [87 (91.6%) women; with mean age = 40.05 (SD ± 11.16)] consecutive patients with SLE. The mean duration of the disease was 155 months (SD ± 105.6). The control group consisted of 64 controls [53 (82.8%) women; p = 0.134] with mean age = 40.09 years (SD ± 6.61) (p = 0.97). Anti-P antibodies were observed in 16 (16.8%) of SLE patients and in none of the controls (p = 0.002). Olfactory dysfunction was observed in 42 (44.2%) of SLE patients at the start of the study and in 9 (14.06%) of the controls (p <0.001). ). In addition to lower TDI scores [significant SLE scores = 28.79 (SD ± 5.46) versus mean values of controls = 32.38 (SD ± 5.28); p <0.001), SLE patients had significantly lower scores in all three SST sub-tests compared to controls. We observed significantly lower left hippocampal (p <0.001) and left amygdala (p <0.013) volumes in SLE when compared to controls at baseline. We did not observe difference in the hippocampus and the amigdala between the two groups. Olfactory performance remained stable over the 2-year period in 95 patients, such as mean BAI, BDI scores, and hippocampal and amygdala volumes. Conclusion: Olfactory manifestations are more frequently observed in SLE than in controls, but remain stable over two years in SLE. Disease activity, anxiety symptoms and depression and volume of the amygdala and hippocampus are associated with olfactory changes in SLE, and we not found associations between levels anti-P and olfactory manifestations (AU) | |
| FAPESP's process: | 14/00734-7 - Longitudinal evaluation of smell alteration in systemic lupus erythematosus: importance of anti-P ribosomal and atrophy of limbic system structures |
| Grantee: | Fernando Augusto Peres |
| Support Opportunities: | Scholarships in Brazil - Doctorate |