MicroRNAs and oxidated biomolecules as possible biomarkers of nephrotoxicity induced by cisplatin in patients with head and neck cancer

Author(s)

Júlia Coelho França Quintanilha

• Document type: Doctoral Thesis
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas
• Defense date: 2020-09-03

Examining board members

Patricia Moriel; Cláudia Vianna Maurer Morelli; Catarina Raposo Dias Carneiro; Gilberto Castro Junior; Patrícia de Carvalho Mastroianni

• Advisor: Patricia Moriel

Abstract

Cisplatin is used to treat a variety of tumors, including head and neck tumors. Its use is limited due to its toxities, mainly nephrotoxicity, which is caused by oxidative stress. The aim of this study was to evaluate microRNAs (miRNAs) and oxidized biomolecules as possible biomarkers of cisplatin-induced nephrotoxicity. Blood samples were collected from 81 head and neck cancer patients before (baseline) and after 5 (D5) and 20 (D20) days following cisplatin administration (80-100 mg/m2) for toxicity assessment, which were classified into grades according to Common Terminology Criteria for Adverse Events v4.0. The plasmatic oxidative stress biomarkers, malondialdehyde (MDA) and carbonylated proteins, and urinary oxidative stress biomarker, 8-isoprostane, were measured at baseline and D5. MiRNAs were extracted from plasma and urine collected at D5 from 6 patients with and 6 patients without nephrotoxicity, constituing the nephrotoxicity and no nephrotoxicity groups, respectively... The abstract is available with the full electronic document (AU)

• FAPESP's process: 17/02338-0 - MicroRNAs and oxidated molecules as possible biomarkers of cisplatin-induced nephrotoxicity in patients with head and neck cancer
• Grantee: Júlia Coelho França Quintanilha
• Support Opportunities: Scholarships in Brazil - Doctorate