MicroRNAs and oxidated molecules as possible biomarkers of cisplatin-induced nephrotoxicity in patients with head and neck cancer

• Grant number: 17/02338-0
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2017
• Effective date (End): May 31, 2020
• Field of knowledge: Health Sciences - Pharmacy
• Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Patricia Moriel
• Grantee: Júlia Coelho França Quintanilha
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 18/04491-2 - Genetic susceptibility to severe toxicities and toxic deaths among 1,626 cancer patients trated with bevacizumab: implications for treatment and personalized therapy, BE.EP.DR

Abstract

The most effective treatment for advanced head and neck cancer is cisplatin concomitant radiotherapy. However, its use is limited due to its toxicities, especially the nephrotoxicity, which is mainly caused by oxidative stress. There is a necessity to identify new biomarkers of nephrotoxicity, since traditional markers are poorly sensitive and non-specific. Among the biomarkers studied, we have microRNAs (miRNAs) and oxidized biomolecules. The objective of this study will be to evaluate miRNAs and oxidized biomolecules as possible biomarkers of cisplatin-induced nephrotoxicity in patients with head and neck cancer. This is an analytical, experimental, clinical, single-arm, prospective, quantitative study which sampling will be non-probabilistic of the consecutive type, performed at HC / UNICAMP. Patients with head and neck cancer who start treatment with cisplatin (80-100mg / m2 every 21 days) and radiation therapy will be included. Nephrotoxicity, gastrointestinal toxicities and myelotoxicity will be evaluated for severity according to CTCAE v4. The expression of plasma and urinary miRNAs in relation to cisplatin-induced nephrotoxicity will be evaluated and plasma and urinary oxidative stress measured. Treatment response, overall survival, and disease-free survival will also be evaluated. For statistical analysis Chi-square, Fisher exact, Mann-Whitney and ANOVA tests will used for repeated measurements, considering p <0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FRANCA QUINTANILHA, JULIA COELHO; FRANCINETTE SAAVEDRA, KATHLEEN; VISACRI, MARILIA BERLOFA; MORIEL, PATRICIA; SALAZAR, LUIS A. Role of epigenetic mechanisms in cisplatin-induced toxicity. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v. 137, p. 131-142, MAY 2019. Web of Science Citations: 1.