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| Author(s): |
Beatriz Carmona Ferreira Pileggi
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba (FOP) |
| Defense date: | 2025-01-28 |
| Examining board members: |
Ana Cláudia Rossi;
Roberta Okamoto;
Sárah Teixeira Costa;
Juliana Haddad;
Felippe Bevilacqua Prado
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| Advisor: | Ana Cláudia Rossi |
| Abstract | |
Introduction: Postmenopausal osteoporosis is the most common skeletal disease with high incidence in society, characterized by reduced bone mass. The number and distribution of teeth affect occlusion, which in turn influences masticatory capacity. Bite force and finite element analysis can provide important mechanical data for understanding the function and effectiveness of the masticatory system. The present study aimed to analyze whether tooth loss, combined with diet type and ovariectomy, causes mechanical changes in the maxillary alveolar bone of Wistar rats. Methods: Eighty female rats (Wistar strain) were used. Bilateral ovariectomy was performed on rats in the OVX group and surgical simulation on rats in the SHAM group. Thirty days after ovariectomy surgery, the upper right incisor was extracted, and a soft diet was introduced to half of the animals. In vivo measurement of bite force on the incisors was performed on all animals after the day of tooth extraction. Euthanasia occurred at 30 and 60 days after tooth extraction. After euthanasia, the left and right maxillae were dissected for in vitro analysis. The maxillae were subjected to microcomputed tomography for finite element analysis (in silico). Three-dimensional reconstructions of dentoalveolar structures were performed to construct the finite element models. The models were characterized according to the normal dentition and dental extraction. The SHAM and OVX groups, as well as the diet and time were characterized by mechanical properties and bite force values. Statistical tests were performed to verify whether there were differences between the groups. Results: For bite force, the Kruskal-Wallis test showed that there was a statistically significant difference between the groups (P<0.0001). The highest bite force was detected in the OVX group with tooth extraction and intake of a hard diet, and the lowest bite force was detected in the SHAM group with a soft diet without tooth extraction. The computational simulation presented major difference in the strain distribution in the groups with normal dentition compared to the groups with dental extraction. Conclusion: The association involving dental extraction and osteoporosis were the main factors which led to increase the bite force and, consequently, the higher number of alveolar bone strain (AU) | |
| FAPESP's process: | 21/04776-0 - Effect of Osteoporosis on mechanical properties of alveolar bone in Wistar rats submitted to dental extraction and diet modification: in vivo, in vitro and in silico analysis |
| Grantee: | Beatriz Carmona Ferreira Pileggi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |