Obtaining and characterization of simvastatin loaded PLDLA microspheres

Author(s)

Cintia Cristina Santos

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Mecânica
• Defense date: 2011-04-07

Examining board members

Eliana Aparecida de Rezende Duek; Maria Clara Filippini Ierardi; Maria Lourdes Peris Barbo

• Advisor: Eliana Aparecida de Rezende Duek

Abstract

Drug delivery systems have been indicated by health professional as an alternative to improve drug efficacy and acceptability of the treatment to the patient. Bioreabsorbable polymers, its copolymers and blends have presented advantages and importance in relation to others polymers due to characteristics like: biocompatibility, easily to process, hydrolytic degradation, byproducts are nontoxic, control to microspheres morphology size distribution and consequently degradation rate and drug release kinetics. The aim of this work was to obtain and characterize simvastatin loaded PLDLA microspheres. The Poly L-co-D,L lactic acid (PLDLA) is a Poly lactic acid (PLA) copolymer. Simvastatin is a drug used for hyperlipidemia, that locally applied induces bone formation and fracture healing. The oil/water single emulsion/solvent evaporation technique produced microspheres in a spherical and smooth surface, micrometric size, large diameter distribution, the microencapsulation process did not interfere in the polymer chemical structure and the drug is in a amorphous state in the polymeric matrix. Simvastatin encapsulation efficiency was 96,2% and in vitro drug release showed a burst release, which characterize large diameter distribution systems. Simvastatin had degradated in its hydroxiacid and non-identified products. Microspheres released the drug up to 30º day while the degradation process occured. Thus, the PLLA microspheres obtained are promising to apply as a carrier drug delivery system (AU)

• FAPESP's process: 09/06831-6 - Obtention, characterization and aplication of simvastatin loaded PLDLA microspheres
• Grantee: Cíntia Cristina Santos
• Support Opportunities: Scholarships in Brazil - Master