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| Author(s): |
Eduardo Gonzalo Espinoza Carreon
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Carlos. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Matemáticas e de Computação (ICMC/SB) |
| Defense date: | 2013-06-25 |
| Examining board members: |
Fernando Vieira Paulovich;
Haim Levkowitz;
Osvaldo Novais de Oliveira Junior
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| Advisor: | Fernando Vieira Paulovich |
| Abstract | |
A sensor or biosensor is an analytical device that aims to identify substances and their concentrations. The efficient employment of sensors allows the solution of many problems in several fields such as chemistry, biology, medicine, pharmacology, environmental sciences, among others. Two problems were the main focus of this master\'s thesis: the diagnosis of diseases and the replacement of human beings by electronic tongues to avoid subjective analysis. The first problem is solved using single molecule detection but presents problems related to the large amount of data generated by sensors Surface Enhanced Raman Spectroscopy (SERS). The second one involves the recalibration of impedance spectroscopy sensors in electronic tongues for them to be replaced when one of them presents defficiencies. We have developed two different approaches to handle these problems, both of them involve information visualization methods making the exploration of large amounts of data more efficiently. The first approach improved the execution time of the single molecule detection process compared to the manual analysis. The number of spectra classified as false positives was also reduced. The second approach, which is a candidate solution to the replacement of sensors in an electronic tongue, employs the definition of the equivalent circuit of Taylor along with Generalized Procrustes Analysis (GPA) to achieve the desired goal. This leads to the recalibration of one sensor into the response of another one, presenting good results. In the future, this could be potentially used to produce more reliable and reproducible systems (AU) | |
| FAPESP's process: | 11/04192-6 - Information visualization techniques for sensing and biosensors data analysis |
| Grantee: | Eduardo Gonzalo Espinoza Carreon |
| Support Opportunities: | Scholarships in Brazil - Master |