Tomographic analysis of bone formation in segmental defect in the mandible of rabbits filled with lyophilized bovine bone block with collagen

Author(s)

Maria Fernanda Conceição Madeira

• Document type: Master's Dissertation
• Press: Bauru.
• Institution: Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB)
• Defense date: 2014-02-19

Examining board members

Eduardo Sant'Ana; Izabel Maria Marchi de Carvalho; Renato Yassutaka Faria Yaedú

• Advisor: Eduardo Sant'Ana

Abstract

Currently implant dentistry has evolved tremendously in the intention of replacing missing teeth, but unfortunately this is not always able, since after tooth loss, in most cases, also the remaining bone is reabsorbed, making it difficult or impossible to install dental implants. This type of bone loss in the jaw or bone loss resulting from surgical resections, are a major concern at present, since the dentists researching bone substitute that restores the shape and contour of the bones of the face and jaws, and/or enabling installation of dental implants. Among the biomaterials, the use of lyophilized bovine bone has become popular and has been gaining ground as it reduces the morbidity of the patient avoiding the removal of autogenous grafts has shown a good and predictable results. In the present study, bone defects were created on the basis of mandible in rabbits, which were grafted blocks lyophilized bovine bone with swines collagen in the experimental groups and control groups left empty. The animals were sacrificed at 0 (immediately after surgery), 3 and 6 months after surgery. The jaws were collected and analyzed using cone beam computed tomography, which analyzed the ability of the graft to aid in bone repair of critical-size defects created in the mandible of rabbits as well as its ability to maintain the contour and shape of the bone. Through the analysis of the tomographic grafted areas was concluded that according to the methodology proposed bovine bone graft with 10% swines collagen was not able to assist in 100% of the bone repair critical size defects created in rabbit jaw, showing a thin layer of soft tissue between the graft and the bed having been efficient space filling of the defect and maintain the bone contour. (AU)

• FAPESP's process: 11/03165-5 - Comparative analysis of 2% and 4% articaine, both with 1:200,000 epinephrine: evaluation of the anesthetic efficacy, intraoperative bleeding and hemodynamic parameters in lower third molar removal
• Grantee: Maria Fernanda Conceição Madeira
• Support Opportunities: Scholarships in Brazil - Master