CV Lattes
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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Argentina
He graduated in physics from the National University of La Plata, Argentina, in 1993, received his doctorate from the same institution in crystallography in 1998, and completed his associate professorship at the University of São Paulo (USP) in 2011. He is currently an Associate Professor A3 at the São Carlos Institute of Physics at the University of São Paulo, where he coordinated the graduate program until February 2024. He is currently Vice-President of the Brazilian Association of Crystallography, Coordinator of the Multiuser Laboratory of Structural Crystallography at IFSC-USP (the oldest structural crystallography laboratory in the country), a level 1B researcher at CNPq, co-editor of Acta Crystallographica E, and Coordinator of the Structural Chemistry Commission of the International Union of Crystallography (SCC-IUCr), and CSD Champion of the Cambridge Crystallographic Data Center. He works as a reviewer for international scientific journals, ad hoc consultant for government institutions, and advisor to several national and international institutions and companies. He has over 500 (WoS) and 1100 (Google Scholar) publications in indexed journals with over 7,000 citations (WOS) and 9,000 (Google Scholar), and has an H-index of 40 (WoS) and 44 in Google Scholar. Among other areas, he has dedicated himself to the planning, development, obtaining, and characterization of new multicomponent solid forms of pharmaceutical ingredients with improved pharmacokinetic and pharmacotechnical properties. Within this area, he co-organized the I and II Latin American Symposium on Polymorphism and Crystallization in Drugs and Medications (LAPOLC 2007 and LAPOLC 2009) and was a consultant for ANVISA, INPI, SINDUSFARMA, as well as a wide range of companies in the pharmaceutical and pharmachemical sector. He has coordinated four major international research projects (CAPES-SECYT, Argentina/Brazil/Uruguay; Capes-Cuba, Capes-UDELAR; CNPq/India), and dozens of national projects, including a PRONEX FAPESP/CNPQ Project in the area of Development of New Inorganic Chemotherapeutics. Other lines of activity include the design and characterization of 3D Metal-Organic Coordination Complexes (MOFs) and the study and characterization of Natural Minerals, and is currently vice-coordinator of the Center for Characterization of Mineral Species (http://www.ifsc.usp.br/~emulabram/). He also has extensive experience in a variety of topics, such as the study of chelating ligand complexes with heavy metals, and the catalytic and biological properties of coordination complexes containing, for example, Ru, Cu, V, Ni, etc. He also conducts research in the area of theoretical and experimental analysis of the electronic charge density of compounds with biological activity or nonlinear optical properties. He is currently collaborating on the implementation of the Small Molecule Crystallography area at the SIRIUS MACACA Line and on the design of the future QUIRI-QUIRI line. He was a member of the X-ray Diffraction Committee of the National Synchrotron Light Laboratory and served as vice-coordinator of the IFSC Graduate Program from 2016 to 2018. He has supervised 15 postdoctoral researchers, supervised 8 doctoral theses, 11 master's theses, and 45 Scientific Initiation theses. He currently supervises 2 master's students, 1 doctoral student, 2 postdoctoral students, and 4 IC students. His research results have led to the filing of 11 invention patents, of which six (6) have been issued. Over the past five years, he has organized and participated as a lecturer in twelve (12) international schools/workshops/symposia, with three more scheduled for the next six months. During this same period, he has given 15 lectures (8 national and 7 international), four courses, and collaborated in the implementation and consolidation of new crystallography laboratories in Brazil (UFRN and UFOP), Argentina (UNSL), and Jamaica (Kingston). (Source: Lattes Curriculum)
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The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic charac…
This research project is focused to the synthesis of new crystalline forms of drugs used in the anti-HIV therapy, followed by the characterization of their solid state physical and chemical properties. These drugs will be subject of crystallization essays in order to obtain new crystalline forms with tailored pharmacokinetic properties. The produced crystalline forms will be characterized…
(Only some records are available in English at this moment)
This research project "Crystal Engineering applied to pharmaceuticals aiming developing new designs via supramolecular synthons: improvement of physicochemical and biopharmaceutical properties to implement, in Brazil, a Pharmaceutical Center for Technological Innovation" aims to obtain new salts and/or drug-drug cocrystals capable of offering pharmacokinetic and pharmacodynamic improveme…
This work plan deals with obtaining and characterizing ruthenium II semi-sandwich complexes containing ligands of biological interest, as new candidates for metallopharmaceuticals, being an integral part of the thematic project "X-Ray Diffraction as a Tool in the Development of Potential Drugs" (2017/15850-0). In the synthesis stage, it is intended to carry out a "screening" to evaluate t…
The present project aim characterization, mainly by single crystal x-ray diffraction, as well as and the analisys of the structural and crystallographic properties analysis of organometallic complex with pharmacological activity. This project also involves the correlations of this structural information with the corresponding physical-chemical properties and biological application. The bi…
The present project aim the synthesis and characterizing ruthenium II semi-sandwich complexes containing binders of biological interest, as new candidates for metallopharmaceuticals, being an integral part of the thematic project "X-Ray Diffraction as a Tool in the Development of Potential Drugs" (2017 / 15850-0). In the synthesis stage, it is intended to perform a "screening" to evaluate…
(Only some records are available in English at this moment)
This research proposal aims the development of theoretical and experimental Charge Density (CD) studies of new solid forms of antiretroviral drugs, initially of the lamivudine (3TC), one of the most marketed and effective anti-HIV and anti-hepatitis-B drug. The different solid forms derivatives of the lamivudine and other anti-HIV drugs have been obtaining through crystal engineering appr…
The depression have been characterized as one of most major global health challenge. In the disease treatment, the Selective Serotonin Reuptake Inhibitors (SSRIs) constitute a important pharmaceutical intervention. In particular, Paroxetine, Fluoxetine and Sertraline are antidepressants widely used in depression clinic treatment. This research project aims the development and characteriza…
| 1 / 1 | Ongoing grants |
| 8 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 22 / 16 | All research grants and scholarships |
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