Geraldo Aleixo da Silva Passos Júnior
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), master's at Biochemistry from Universidade de São Paulo (1986) and doctorate at Biochemistry from Universidade de São Paulo (1988). Has experience in Immunology, focusing on Imunogenetics, acting on the following subjects: microarrays, transcriptoma, cluster and tree view, timo and rna. (Source: Lattes Curriculum)
- Effect of CRISPR-Cas9-induced mutations in the Aire gene (APS1 syndrome) on protein conformation, mTEC cell transcriptome and their interaction with thymocytes, AP.TEM
Abstract
The Autoimmune regulator (Aire) gene located on the human chromosome 21q22.3 or on mouse (Mus musculus) 10qC1, is a controller of the central immune tolerance and consequently the onset of autoimmune diseases. Aire share ~ 80% human-mouse similarity and it regulates the transcription of genes that encode peripheral tissue antigens (PTAs) in medullary thymic epithelial cells (mTECs) (pro...
- The function of the AIRE gene and of Micro RNAs in the control of adhesion between medullary thymic epithelial cells with thymocytes, AP.R
Abstract
The thymus plays a role in the induction of immunological tolerance to tissue related antigens (TRA). Within the thymic medulla, the medullary thymic epithelial cells (mTECs) express hundreds of these TRAs, which, in turn, represent virtually all organs and tissues of the body. Due to the diversity of representation, this phenomenon was called promiscuous gene expression (PGE) which is ...
- Control of the transcriptome in diabetes mellitus, AP.TEM
Abstract
Molecular genetic studies will be performed on type-1 (T1-D), type-2 (T2-D) and gestational (GD) diabetes, evaluating the large scale gene expression profiles (transcriptome level). T1-D is an autoimmune disorder caused by the immunological destruction of pancreatic β- cells, leading to insulin dependence. Although several susceptibility loci have been described in association with T1-...
- Transcriptome project: large scale gene expression analysis using DNA-Arrays, AP.TEM
Abstract
The Transcriptome project is included in the field of functional genomics, i.e., the meaning of the DNA sequence function at the genomic level. Although much has been known in terms of human and non-human genomic DNA or cDNA sequencing data, few studies have been conducted on the function of these genes. The wide scale gene expression evaluation is the first step on the understanding of...
- Effect of the Aire gene on the chemotactic property of medullary thymic epithelial cells on thymocytes, BP.IC
Abstract
The Autoimmune regulator (Aire) gene (human chromosome 21q22.3 and Mus musculus 10qC1), is a controller of central immune tolerance and the emergence of autoimmune diseases. The Aire sequence presents ~ 80% man-mouse similarity and this gene regulates the transcription of peripheral tissue autoantigen genes (PTAs) in medullary thymic epithelial cells (mTECs). This phenomenon was termed ...
- Control of the transcriptome in Diabetes Mellitus, BP.TT
- Profiles of promiscuous gene expression in the thymus of NOD (non obese diabetic) mice during onset of type 1 diabetes mellitus (DM-1), BP.MS
*Updated April 20, 2019
| 1 / 1 | Ongoing research grants |
| 10 / 3 | Completed research grants |
| 29 / 3 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 41 / 7 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 20 |
| Citations | 225 |
| Cit./Article | 11.3 |
| Data from Web of Science | |
CARMINATI, PATRICIA OLIVEIRA; MELLO, STEPHANO SPANO; FACHIN, ANA LUCIA; JUNTA, CRISTINA MORAES; SANDRIN-GARCIA, PAULA; CARLOTTI, CARLOS GILBERTO; DONADI, EDUARDO ANTONIO; SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line. GENETICS AND MOLECULAR BIOLOGY, v. 33, n. 1, p. 159-168, 2010. Web of Science Citations: 5. (99/12135-9)
PEZZI, NICOLE; ASSIS, AMANDA FREIRE; COTRIM-SOUSA, LARISSA COTRIM; LOPES, GABRIEL SARTI; MOSELLA, MARITZA SALAS; LIMA, DJALMA SOUSA; BOMBONATO-PRADO, KARINA F.; PASSOS, GERALDO ALEIXO. Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction. Molecular Immunology, v. 77, p. 157-173, SEP 2016. Web of Science Citations: 5. (13/17481-1)
DERNOWSEK, JANAINA A.; PEREIRA, MILENA C.; FORNARI, THAIS A.; MACEDO, CLAUDIA; ASSIS, AMANDA F.; DONATE, PAULA B.; BOMBONATO-PRADO, KARINA F.; PASSOS-BUENO, MARIA RITA; PASSOS, GERALDO A.. Posttranscriptional Interaction Between miR-450a-5p and miR-28-5p and STAT1 mRNA Triggers Osteoblastic Differentiation of Human Mesenchymal Stem Cells. Journal of Cellular Biochemistry, v. 118, n. 11, p. 4045-4062, NOV 2017. Web of Science Citations: 6.
OLIVEIRA, ERNNA H.; MACEDO, CLAUDIA; COLLARES, CRISTHIANNA V.; FREITAS, ANA CAROLINA; DONATE, PAULA BARBIM; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells. FRONTIERS IN IMMUNOLOGY, v. 7, NOV 23 2016. Web of Science Citations: 4. (13/17481-1, 08/56594-8)
FORNARI, THAIS A.; DONATE, PAULA B.; ASSIS, AMANDA F.; MACEDO, CLAUDIA; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Comprehensive Survey of miRNA-mRNA Interactions Reveals That Ccr7 and Cd247 (CD3 zeta) are Posttranscriptionally Controlled in Pancreas Infiltrating T Lymphocytes of Non-Obese Diabetic (NOD) Mice. PLoS One, v. 10, n. 11, NOV 25 2015. Web of Science Citations: 11. (13/08216-2, 08/56594-8)
XAVIER, DANILO J.; TAKAHASHI, PAULA; MANOEL-CAETANO, FERNANDA S.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; SAKAMOTO-HOJO, ELZA T.. One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice, v. 105, n. 3, p. 356-363, SEP 2014. Web of Science Citations: 6. (10/12069-7, 08/56594-8)
DONATE, PAULA B.; FORNARI, THAIS A.; MACEDO, CLAUDIA; CUNHA, THIAGO M.; NASCIMENTO, DANIELE C. B.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; CUNHA, FERNANDO Q.; PASSOS, GERALDO A.. T Cell Post-Transcriptional miRNA-mRNA Interaction Networks Identify Targets Associated with Susceptibility/Resistance to Collagen-induced Arthritis. PLoS One, v. 8, n. 1, JAN 24 2013. Web of Science Citations: 13. (08/56594-8)
MANOEL-CAETANO, FERNANDA S.; XAVIER, DANILO J.; EVANGELISTA, ADRIANE F.; TAKAHASHI, PAULA; COLLARES, CRISTHIANNA V.; PUTHIER, DENIS; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; et al. Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease. Gene, v. 511, n. 2, p. 151-160, DEC 15 2012. Web of Science Citations: 25. (10/12069-7, 08/56594-8)
MENDES-DA-CRUZ, DANIELLA A.; LEMOS, JULIA P.; PASSOS, GERALDO A.; SAVINO, WILSON. Abnormal T-Cell Development in the Thymus of Non-obese Diabetic Mice: Possible Relationship With the Pathogenesis of Type 1 Autoimmune Diabetes. FRONTIERS IN ENDOCRINOLOGY, v. 9, JUL 12 2018. Web of Science Citations: 0. (13/17481-1)
PASSOS, GERALDO A.; SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; MENDES-DA-CRUZ, DANIELLA A.. Update on Aire and thymic negative selection. IMMUNOLOGY, v. 153, n. 1, p. 10-20, JAN 2018. Web of Science Citations: 3. (13/17481-1)
PASSOS, GERALDO ALEIXO; MENDES-DA-CRUZ, DANIELLE AREAS; OLIVEIRA, ERNNA HERIDA. The thymic orchestration involving Aire, miRNAs, and cell-cell interactions during the induction of central tolerance. FRONTIERS IN IMMUNOLOGY, v. 6, JUL 14 2015. Web of Science Citations: 13. (13/17481-1, 13/08216-2)
XAVIER, DANILO J.; TAKAHASHI, PAULA; EVANGELISTA, ADRIANE F.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; DONADI, EDUARDO A.; PASSOS, GERALDO A.; SAKAMOTO-HOJO, ELZA T.. Assessment of DNA damage and mRNA/miRNA transcriptional expression profiles in hyperglycemic versus non-hyperglycemic patients with type 2 diabetes mellitus. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 98-110, JUN 2015. Web of Science Citations: 10. (10/12069-7, 08/56594-8)
MACEDO, CLAUDIA; OLIVEIRA, ERNNA H.; ALMEIDA, RENATA S.; DONATE, PAULA B.; FORNARI, THAIS A.; PEZZI, NICOLE; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A.. Aire-dependent peripheral tissue antigen mRNAs in mTEC cells feature networking refractoriness to microRNA interaction. Immunobiology, v. 220, n. 1, p. 93-102, JAN 2015. Web of Science Citations: 10. (13/17481-1, 13/08216-2, 08/56594-8)
TAKAHASHI, PAULA; XAVIER, DANILO J.; EVANGELISTA, ADRIANE F.; MANOEL-CAETANO, FERNANDA S.; MACEDO, CLAUDIA; COLLARES, CRISTHIANNA V. A.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; RASSI, DIANE M.; DONADI, EDUARDO A.; et al. MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus. Gene, v. 539, n. 2, p. 213-223, APR 15 2014. Web of Science Citations: 27. (10/12069-7, 08/56594-8)
COLLARES, C. V. A.; EVANGELISTA, A. F.; XAVIER, D. J.; TAKAHASHI, P.; ALMEIDA, R.; MACEDO, C.; MANOEL-CAETANO, F.; FOSS, M. C.; FOSS-FREITAS, M. C.; RASSI, D. M.; et al. Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus. MOLECULAR BIOLOGY REPORTS, v. 40, n. 9, p. 5351-5358, SEP 2013. Web of Science Citations: 10. (10/12069-7, 08/56594-8)
R.G.P. QUEIROZ; M.C. TAMIA-FERREIRA; I.F. CARVALHO; F.C. PETEAN; G.A.S. PASSOS. Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus. Brazilian Journal of Medical and Biological Research, v. 34, n. 4, p. 525-528, Abr. 2001.
EVANGELISTA, ADRIANE F.; COLLARES, CRISTHIANNA V. A.; XAVIER, DANILO J.; MACEDO, CLAUDIA; MANOEL-CAETANO, FERNANDA S.; RASSI, DIANE M.; FOSS-FREITAS, MARIA C.; FOSS, MILTON C.; SAKAMOTO-HOJO, ELZA T.; NGUYEN, CATHERINE; et al. Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation. BMC MEDICAL GENOMICS, v. 7, MAY 23 2014. Web of Science Citations: 12. (10/12069-7, 08/56594-8)
PASSOS‚ G.A.S.; PROENÇA PICANÇO‚ V.. Frequency of the δ< i> ccr 5 deletion allele in the urban Brazilian population. Immunology Letters, v. 61, n. 2, p. 205-207, 1998.
SPECK-HERNANDEZ, CESAR A.; ASSIS, AMANDA F.; FELICIO, RAFAELA F.; COTRIM-SOUSA, LARISSA; PEZZI, NICOLE; LOPES, GABRIEL S.; BOMBONATO-PRADO, KARINA F.; GIULIATTI, SILVANA; PASSOS, GERALDO A.. Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes. FRONTIERS IN IMMUNOLOGY, v. 9, MAY 7 2018. Web of Science Citations: 0. (13/17481-1)
SANDRIN-GARCIA‚ P.; MACEDO‚ C.; MARTELLI‚ LR; RAMOS‚ ES; GUION-ALMEIDA‚ ML; RICHIERI-COSTA‚ A.; PASSOS‚ GAS. Recurrent 22q11. 2 deletion in a sibship suggestive of parental germline mosaicism in velocardiofacial syndrome. Clinical Genetics, v. 61, n. 5, p. 380-383, 2002.
MACEDO‚ C.; MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Onset of T-cell receptor V [beta] 8.1 and D [beta] 2.1 V (D) J recombination during thymus development of inbred mouse strains. Immunology Letters, v. 69, n. 3, p. 371-373, 1999.
DA SILVA‚ M.I.; PASSOS‚ G.A.S.. The human immunoglobulin variable lambda locus IGLV9 gene is a monomorphic marker in the urban Brazilian population. Immunology Letters, v. 69, n. 3, p. 369-370, 1999.
MORAES JUNTA‚ C.; PASSOS‚ G.A.S.. Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11. 2/IGLV). IMMUNOGENETICS, v. 55, n. 1, p. 10-15, 2003.
MELLO, STEPHANO S.; FACHIN, ANA L.; JUNTA, CRISTINA M.; SANDRIN-GARCIA, PAULA; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.; SAKAMOTO-HOJO, ELZA T.. Delayed Effects of Exposure to a Moderate Radiation Dose on Transcription Profiles in Human Primary Fibroblasts. Environmental and Molecular Mutagenesis, v. 52, n. 2, p. 117-129, MAR 2011. Web of Science Citations: 8. (99/12135-9)
BASSI, C. L.; MELLO, S. S.; CARDOSO, R. S.; GODOY, P. D. V.; FACHIN, A. L.; JUNTA, C. M.; SANDRIN-GARCIA, P.; CARLOTTI, C. G.; FALCAO, R. P.; DONADI, E. A.; et al. Transcriptional changes in U343 MG-a glioblastoma cell line exposed to ionizing radiation. HUMAN & EXPERIMENTAL TOXICOLOGY, v. 27, n. 12, p. 919-929, DEC 2008. Web of Science Citations: 14. (99/12135-9)
SAKAMOTO-HOJO, E. T.; PEREIRA, E.; FACHIN, A. L.; CARDOSO, R. S.; DONADI, E. A.; PASSOS, G. A. S.; MELLO, S. S.; JUNTA, C. M.. Gene expression profiles in human cells submitted to genotoxic stress. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, v. 544, n. 2-3, p. 403-413, Nov. 2003. (99/12135-9)
TREVISAN, G. L.; TAMIA-FERREIRA, M. C.; PASSOS, G. A. S.; JUNTA, C. M.. Immunoglobulin V-lambda transcription profiling of systemic lupus erythematosus patients reveals biased usage of genes located near the J lambda-C lambda segments. Scandinavian Journal of Immunology, v. 59, n. 4, p. 395-399, abr. 2004. (99/12135-9)
MAGALHÃES, DANIELLE A. R.; MACEDO, CLAUDIA; JUNTA, CRISTINA M.; MELLO, STEPHANO S.; MARQUES, MÁRCIA M. C.; CARDOSO, RENATO S.; SAKAMOTO-HOJO, ELZA T.; DONADI, EDUARDO A.; PASSOS, GERALDO A. S.. Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins. Molecular Immunology, v. 42, n. 9, p. 1043-1048, May 2005. (99/12135-9)
FACHIN, ANA LUCIA; MELLO, STEPHANO SPANO; SANDRIN-GARCIA, PAULA; JUNTA, CRISTINA MORAES; GHILARDI-NETTO, THOMAZ; DONADI, EDUARDO ANTONIO; DA SILVA PASSOS, GERALDO ALEIXO; SAKAMOTO-HOJO, ELZA TIEMI. Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation. JOURNAL OF RADIATION RESEARCH, v. 50, n. 1, p. 61-71, JAN 2009. Web of Science Citations: 43. (99/12135-9)
TREVISAN‚ G.L.; RASSI‚ D.M.; BAIÃO‚ A.M.T.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; TAMIA-FERREIRA‚ M.C.; JUNTA‚ C.M.; FACHIN‚ A.L.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; et al. Using cDNA microarrays to identify human CD19+ B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. AUTOIMMUNITY REVIEWS, v. 5, n. 5, p. 319-323, 2006. (99/12135-9)
RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.S.; FERNANDES‚ A.N.A.P.M.; DEGHAIDE‚ N.N.H.S.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Is HLA Class II Profile Relevant for the Study of Large-Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 305-309, 2006. (99/12135-9)
RASSI‚ D.M.; JUNTA‚ C.M.; FACHIN‚ A.N.A.L.; SANDRIN-GARCIA‚ P.; MELLO‚ S.; MARQUES‚ M.; FERNANDES‚ A.N.A.P.M.; FOSS-FREITAS‚ M.C.; FOSS‚ M.C.; SAKAMOTO-HOJO‚ E.T.; et al. Metabolism genes are among the differentially expressed ones observed in lymphomononuclear cells of recently diagnosed type 1 diabetes mellitus patients. Annals of the New York Academy of Sciences, v. 1079, n. 1, p. 171-176, 2006. (99/12135-9)
PEREIRA‚ E.; TAMIA-FERREIRA‚ M.C.; CARDOSO‚ R.S.; MELLO‚ S.S.; SAKAMOTO-HOJO‚ E.T.; PASSOS‚ G.A.S.; DONADI‚ E.A.. Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus. Immunology, v. 113, n. 1, p. 99-105, 2004. (99/12135-9)
SILVA‚ G.L.; JUNTA‚ C.M.; MELLO‚ S.S.; GARCIA‚ P.S.; RASSI‚ D.M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Profiling Meta-Analysis Reveals Primarily Gene Coexpression Concordance between Systemic Lupus Erythematosus and Rheumatoid Arthritis. Annals of the New York Academy of Sciences, v. 1110, n. 1, p. 33-46, 2007. (99/12135-9)
CARDOSO‚ R.S.; JUNTA‚ C.M.; MACEDO‚ C.; MAGALHÃES‚ D.A.R.; SILVEIRA‚ E.L.V.; PAULA‚ M.O.; MARQUES‚ M.; MELLO‚ S.S.; ZÁRATE-BLADÉS‚ C.R.; NGUYEN‚ C.; et al. Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V (D) J recombination and DNA repair. Molecular Immunology, v. 43, n. 5, p. 464-472, 2006. (99/12135-9)
SOUSA CARDOSO‚ R.; MAGALHÃES‚ D.A.R.; BAIÃO‚ A.M.T.; JUNTA‚ C.M.; MACEDO‚ C.; MARQUES‚ M.; SAKAMOTO-HOJO‚ E.T.; DONADI‚ E.A.; PASSOS‚ G.A.S.. Onset of promiscuous gene expression in murine fetal thymus organ culture. Immunology, v. 119, n. 3, p. 369-375, 2006. (99/12135-9)
FACHIN‚ A.L.; MELLO‚ S.S.; SANDRIN-GARCIA‚ P.; JUNTA‚ C.M.; DONADI‚ E.A.; PASSOS‚ G.A.S.; SAKAMOTO-HOJO‚ E.T.. Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays. RADIATION RESEARCH, v. 168, n. 6, p. 650-665, 2007. (99/12135-9)