CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1965) and ph.d. at Biochemistry from Universidade de São Paulo (1969). Has experience in Biochemistry, acting on the following subjects: ciclo celular, hormônios e oncogenes, fatores peptídicos de crescimento, acth and fgf. (Source: Lattes Curriculum)
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Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
(Only some records are available in English at this moment)
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan lnstitute historically built its strong international reputation. lndeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Structural analysis of protein complexes. (AU)
Once our lab is especialized in cellular signaling and cell cycle control, this flow cytometer will allow us to do better analyzes in both subjects. This equipment is able to: do cell cycle analyzes; mark cell signaling pathways; determine cell species, population dynamics and so on. Moreover, the equipments software permits single cell analyzes, which can be useful to design mathematical…
(Only some records are available in English at this moment)
This research project aims to explore a novel therapeutic approach to cancer proposed by Dias and colleagues in 2019 and 2024, Torres and colleagues (in preparation) and the patent number BR 10 2024 006319-8. The central proposal states that malignant cells, unlike normal cells, undergo cell death when exposed to a specific combination of a mitogen and a defined stress pathway inhibitor. …
Current therapeutic approaches for cancer rely on the inhibition of mitogenic stimuli. Research conducted in our laboratory has demonstrated that the classic growth factor FGF-2 inhibits the proliferation of malignant cells from the Y1 adrenocortical lineage (Dias et al., 2019). Furthermore, it has been observed that the combination of mitogens with stress pathway inhibitors results in th…
(Only some records are available in English at this moment)
We propose that in Ras-driven malignant cells there is a functional interaction between cyclin D1 and this oncogene; in which the main function of cyclin D1 is to guarantee cell survival overcoming the Ras oncogenic stress. We showed in the presented reports that CRISPR-Cas9-mediated cyclin D1 depletion induces p53-independent senescence in Ras-driven carcinoma cells. Moreover, in MEFs cy…
| 4 / 4 | Ongoing grants |
| 16 / 11 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 43 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 66 / 26 | All research grants and scholarships |
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