CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Vitor Leite earned a Bachelor's degree in Physics from the Institute of Physics and Chemistry of São Carlos (IFSC), University of São Paulo (1983), a Master's degree in Applied Physics from the University of São Paulo (1988), and a Ph.D. in Physics/Biophysics from the University of California, San Diego (1995). He was a Visiting Associate Professor at Rice University, at the Center for Theoretical Biological Physics in Houston (2019). He is currently a Full Professor at the Institute of Chemistry of São Paulo State University (UNESP), Araraquara campus. His research experience lies in the field of Molecular Biophysics, with an emphasis on charge transfer reactions and protein folding. (Source: Lattes Curriculum)
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Protein aggregation plays a crucial role in the pathology of neurodegenerative diseases, particularly Alzheimer's disease, where beta-amyloid (AB) peptides form toxic aggregates. Understanding the mechanisms driving AB aggregation is essential for developing therapeutic interventions. This project aims to investigate the energy landscape associated with AB40 and AB42 aggregation using mol…
Understanding the relationships between protein structure, energetics, and function is crucial for elucidating biomolecular processes. This is particularly significant for intrinsically disordered proteins (IDPs), which lack a stable structure under physiological conditions. Due to their extreme malleability, IDPs engage in multiple protein interactions, and their dysfunctions, such as ag…
A large fraction of the proteome of various organisms corresponds to polypeptides that do not form a defined three-dimensional structure. An entirely disordered polypeptide is known as an intrinsically disordered protein (IDP), and a segment of a protein that devoids a stable three-dimensional structure is called an intrinsically disordered region (IDR). It is increasingly recognized that…
(Only some records are available in English at this moment)
The approach of energy landscapes has significantly contributed to the understanding of complex molecular systems such as the protein folding problem. In this scenario, minimalist and simplified models have played a key role. This project will focus on biological macromolecules, in which we will study the energy landscape of proteins and RNAs using simplified computational models and stat…
Understanding the relationship between structure, energetics and functional dynamics of proteins is a major challenge in molecular biophysics. In this project, we will bring together a bi-national, multi-institutional team of leading research groups that will aim to reveal how molecular disorder is utilized during biological function. In particular, we will investigate how partial transie…
(Only some records are available in English at this moment)
This postdoctoral research investigates the energetic landscape of the intrinsically disordered N- and C-terminal tails of p53, a key tumor suppressor protein. Using molecular dynamicssimulations, the study explores how post-translational modifications (phosphorylation,acetylation), and mutations influence the structural transitions of these regions, impacting p53's phase separation and a…
The indiscriminate use of antibiotics has been selecting bacterial strains resistant to abroad spectrum of this type of drug. Thus, the development of new antibiotics that act throughpathways that have not yet been explored and, mainly, which are difficult to adapt to bacteria, is ofgreat interest. Polybia-MP-I (MP-I, or simply MP1) is an antimicrobial peptide (AMP) extractedfrom the veno…
(Only some records are available in English at this moment)
Since the advent of Molecular Biology, the search for fundamental models capable of explaining the relationships among amino acid sequence, protein structure, and protein function has received central attention due to its relevance and impact in various fields of knowledge. Theoretically, the Energy Landscape approach has played a key role in elucidating the protein folding process and fu…
The elucidation of functional mechanisms in proteins is a challenging issue of enormous relevance and important pathologies are associated with their dysfunctions. The energy landscape approach has contributed significantly to the understanding of biomolecular mechanisms, in which the approach to the problem of protein folding is its most notable success. Our group at IBILCE-UNESP has dev…
Faced with the challenge of understanding the process of protein folding through computational simulations, minimalist physical models have emerged based on different premises and experimental observations. A model that presents efficiency and low computational cost is the model based on structure, in which its potential is obtained through the native structure of a protein. Due to its di…
(Only some records are available in English at this moment)
Understanding the processes of protein aggregation, folding, and functional mecha-nisms is a fundamental challenge in the field of biological physics. The energy landscapetheory has emerged as a valuable framework for gaining insights into these complex phenom-ena. In this collaborative project between research groups at CTBP and UNESP, we aim toaddress two key topics utilizing energy lan…
The energy landscape approach has contributed significantly to the understanding of complex molecular systems such as the protein folding problem. In this scenario, minimalist and simplified models have played a fundamental role. This project will focus on biological macromolecules, in which we study the protein and chromatin energy landscape using simplified computational models and stat…
One of the most difficult challenges in science is to find clean and cheap energy sources. The second generation bioethanol seems to be viable a solution to substitute fossil fuel usage. The bioethanol production makes use of sugarcane biomass residues not used directly in the fermentation process. This process involves the degradation of cellulose by specific enzymatic hydrolysis. The t…