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Adriano Defini Andricopulo
CV Lattes
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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Adriano D. Andricopulo is Director of the São Carlos Institute of Physics (IFSC) at the University of São Paulo (USP), President of the São Paulo State Academy of Sciences (ACIESP), a member of the Budget and Patrimony Commission (COP) of USP, and a CNPq Research Productivity Fellow (Level 1A). He is a Full Professor at IFSC/USP, a Full Member of the Brazilian Academy of Sciences (ABC), and a Full Member of the São Paulo State Academy of Sciences (ACIESP). He is a Fellow of the Royal Society of Chemistry (RSC) and a Fellow of the International Union of Pure and Applied Chemistry (IUPAC). He is a Full Member of the Steering Committee of the Biotechnology Fund (CT-BIOTEC) of the National Fund for Scientific and Technological Development (FNDCT) and a member of the Management Council of the São Carlos Campus. He holds a B.Sc. degree in Chemistry from the Federal University of Santa Maria (UFSM) and M.Sc. and Ph.D. degrees in Organic Chemistry from the Federal University of Santa Catarina (UFSC), including a doctoral sandwich period and a postdoctoral fellowship in Medicinal Chemistry at the University of Michigan. His main research interests focus on medicinal chemistry and the discovery and development of natural and synthetic drugs and medicines for the treatment of neglected tropical diseases and cancer. He is Coordinator of the Special Center for Research and Innovation in Drug Discovery Sciences (CEPIMED/CEPIx) at the University of São Paulo (USP) and a member of the Steering Committee of the Comprehensive Center for Precision Oncology (C2PO) at the University of São Paulo (USP). He is Technology Transfer Coordinator of the Research and Innovation Center for Biodiversity and Drug Discovery (CIBFarCEPID/FAPESP). He previously served as Head of the Department of Physics and Interdisciplinary Science (FCI) and President of the Research Commission at IFSC-USP. He was Scientific Coordinator of the National Institute of Science and Technology in Biodiversity and Natural Products (INCT-BioNat). He has delivered more than 450 conferences, lectures, and seminars in Brazil and abroad. He has served on several national and international evaluation committees and was Coordinator of the Chemistry Advisory Committee (CA-QU) of CNPq. He served as President of the Brazilian Chemical Society (SBQ) and President of the World Chemistry Congress (IUPAC-2017). He also served as President-Elect, Secretary General, Vice-Director, and Director of the Medicinal Chemistry Division, and as a member of the Advisory Council of SBQ. He served as Regional Secretary of the Brazilian Society for the Advancement of Science (SBPC São Paulo, Subarea III). He was Coordinator of the WHO Collaborating Center for Reference in Medicinal Chemistry for Chagas Disease in Brazil (WHOTDR/UNICEF/UNDP/World Bank) and Vice-Coordinator of the National Institute of Science and Technology for Structural Biotechnology and Medicinal Chemistry in Infectious Diseases (INBEQMeDI). He was an Affiliated Member of the Brazilian Academy of Sciences (ABC). He also served as a member of the Division of Chemistry and Human Health and of the International Advisory Board of IUPAC-2015 (South Korea), and as a member of the International Advisory Board of the IUPAC Centenary (IUPAC-2019, France). (Source: Lattes Curriculum)
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| An agenda for forgotten diseases |
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Research grants
- FAPESP 60 years and the state of the art of science in the State of São Paulo in connection with the Brazilian and World development, AP.R
Abstract
Science is the fundamental basis of the knowledge society and the engine of economic, social and technological progress. Each nation outlines its future based on investment in Science, Technology and training of highly qualified human resources in all areas of knowledge. A modern and innovative society has its foundation in Science, strategically aligned with the Millennium Goals for Sust…
- Converting natural product leads into structure- and ligand-based drug discovery campaigns against Leishmaniasis and Chagas' Disease, AP.TEM
Abstract
The lack of robustly validated drug targets has proved a significant barrier to the discovery of new treatments for visceral leishmaniasis and Chagas' disease. Furthermore, target deconvolution studies with active leads emerging from current small molecule phenotypic screening have confirmed that the same relatively few molecular targets are being hit repeatedly. This project aims to ad…
- Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates, AP.BTA.TEM
Abstract
An International Cooperative Biodiversity Group (ICBG) with an interdisciplinary leadership team of physicians, pharmacologists, evolutionary biologists, and chemists will discover and develop therapeutic agents produced by Brazilian symbiotic bacteria. The team will target three therapeutic areas: 1) infectious fungal pathogens, 2) Chagas disease and leishmaniasis, and 3), cancers of the…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Integrated Evaluation of Pharmacokinetic and Biological Properties of Drug Candidates through Experimental and Computational Approaches, BP.DD
Abstract
Neglected tropical diseases (NTDs) are a group of 21 diseases prevalent in tropical and subtropical regions, affecting over 1 billion people. Among this diverse group of diseases are Chagas disease and leishmaniasis, which stand out as two of the most important NTDs. Both are caused by kinetoplastid parasites and affect millions of people worldwide every year. Chemotherapeutic treatment o…
- Translational Drug Discovery for Neglected Tropical Diseases through Integrated Experimental and In Silico Approaches., BP.DD
Abstract
Chemical compounds of synthetic origin have been consolidating themselves as promising alternatives in the search for new therapeutic agents, especially in neglected areas of medicine. Studies indicate that both synthetic and natural compounds have great potential as sources of new drugs for the treatment of leishmaniasis and Chagas disease (Ortiz-Pérez et al., 2021), with approximately 4…
- Molecular Fingerprinting for Computational Screening of Leishmania Inhibitors, BP.EVC
Abstract
Identify new drug candidates, of natural or synthetic origin, for the treatment of leishmaniasis through the integration of interdisciplinary approaches in medicinal chemistry, biology, biochemistry, artificial intelligence, and molecular modeling. The project aims to promote scientific innovation and advance public health, while also strengthening the training of new researchers through …
- Machine Learning Applied to Trypanosoma Inhibitor Screening, BP.EVC
Abstract
Identify new drug candidates, of natural and/or synthetic origin, for the treatment of Chagas disease. The project seeks to integrate interdisciplinary approaches in medicinal chemistry, biology, biochemistry, artificial intelligence, and molecular modeling. The initiative aims to foster scientific innovation and advance public health, while strengthening the training of new researchers t…
- Evaluation of drug candidates for Chagas Disease, BP.EVC
Abstract
Chagas disease is a neglected tropical disease that affects between 6 and 7 million people and is considered a global health problem due to the migratory flow of infected individuals. The highest incidences of Chagas disease are recorded in Latin America, where it is estimated that approximately 75 million people are at risk of contracting the disease worldwide. Additionally, over 10,000 …
(Only some records are available in English at this moment)
Scholarships abroad
- Pathway toward catastrophe: cellular dynamics on hit-to-lead compound optimisation for current drug discovery pipelines, BE.EP.DR
Abstract
Microtubules (MTs) are intracellular polymers that act as fundamental components of eukaryotic cells. Recent advances in protein purification techniques have begun to shed light on the importance of MTs intrinsic dynamic properties such as growth and shrinkage-both regulated by a cohort of molecular motors and microtubule-associated proteins. The dynamic instability of the MT cytoskeleton…
- Pharmacokinetic and drug metabolism studies in drug discovery and development, BE.EP.DR
Abstract
Cruzain (EC 3.4.22.51) is the major cysteine protease from Trypanosoma cruzi, the Chagas disease etiological agent. Due to its biological relevance, this enzyme is considered one of the most relevant targets to develop new anti-chagasics, which is urgent once the available therapy is old and very toxic due to a blend of unsatisfactory side effects and lack of efficacy. In this way, the st…
- Structural studies of microtubule polymerization dynamics and its modulation by the action of anticancer drugs, BE.EP.DD
Abstract
Cancer is the name of a group of devastating diseases characterized by uncontrolled growth and multiplication of abnormal cells capable of invading nearby structures and spread in various regions of the body. These malignant cells fail to respond to control and defense mechanisms of the body, continually doubling in a disorderly manner and causing tumors. The world scenario caused by deva…