graduate at Química Industrial from Universidade Federal de Santa Maria (1993), master's at Chemistry from Universidade Federal de Santa Catarina (1996) and ph.d. at Química Orgânica from Universidade Federal de Santa Catarina (1999). Has experience in Chemistry, acting on the following subjects: química medicinal, inibidores enzimáticos, relações entre a estrutura e a atividade (sar) and qsar. (Source: Lattes Curriculum)
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The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of C…
Science is the fundamental basis of the knowledge society and the engine of economic, social and technological progress. Each nation outlines its future based on investment in Science, Technology and training of highly qualified human resources in all areas of knowledge. A modern and innovative society has its foundation in Science, strategically aligned with the Millennium Goals for Sust…
The lack of robustly validated drug targets has proved a significant barrier to the discovery of new treatments for visceral leishmaniasis and Chagas' disease. Furthermore, target deconvolution studies with active leads emerging from current small molecule phenotypic screening have confirmed that the same relatively few molecular targets are being hit repeatedly. This project aims to ad…
An International Cooperative Biodiversity Group (ICBG) with an interdisciplinary leadership team of physicians, pharmacologists, evolutionary biologists, and chemists will discover and develop therapeutic agents produced by Brazilian symbiotic bacteria. The team will target three therapeutic areas: 1) infectious fungal pathogens, 2) Chagas disease and leishmaniasis, and 3), cancers of the…
Chagas disease is a neglected tropical disease that affects between 6 and 7 million people and is considered a global health problem due to the migratory flow of infected individuals. The highest incidences of Chagas disease are recorded in Latin America, where it is estimated that approximately 75 million people are at risk of contracting the disease worldwide. Additionally, over 10,000 …
Neglected tropical diseases (NTDs) are a group of endemic illnesses that primarily, but not exclusively, affect low-income populations in tropical and subtropical regions of the world. They impact around 1 billion people globally and represent a major public health issue. Among the NTDs, leishmaniasis stands out as a parasitic disease that manifests in two forms: visceral and cutaneous, w…
Pharmacokinetics (PK) is the study of the time course of drug absorption, distribution, metabolism and excretion (ADME), and how these ADME processes are related to the intensity and time course of the pharmacological (therapeutic and toxic) effects of drugs. Orally delivered pharmacologically active compounds must have favorable absorption and clearance properties and satisfactory metabo…
(Only some records are available in English at this moment)
Among the 20 Neglected Tropical Diseases (NTDs) mentioned by the World Health Organization (WHO), Chagas disease and leishmaniasis stand out for their high incidences of contagion and the high number of social disabilities. Presented in tropical and subtropical regions related to poverty conditions, predominantly in Africa, Asia and the Americas, it is estimated that 1.7 million individua…
Among the twenty Neglected Tropical Diseases (NTDs) described by the World Health Organization (WHO), Chagas disease and leishmaniasis stand out due to the high incidence of contagion and incapacitation. Present in tropical and subtropical regions associated with conditions of poverty, predominantly in Africa, Asia and the Americas, it is estimated that more than a 1 million individuals a…
The Work Plan comprises the development of research activities in the laboratory using modern techniques of structure-based and ligand-based drug design. The scientific activities will focus on two diseases considered of high priority by the World Health Organization: Chagas disease and leishmaniasis. Experimental biochemical screenings will be performed to identify candidates for molecul…
(Only some records are available in English at this moment)
Microtubules (MTs) are intracellular polymers that act as fundamental components of eukaryotic cells. Recent advances in protein purification techniques have begun to shed light on the importance of MTs intrinsic dynamic properties such as growth and shrinkage-both regulated by a cohort of molecular motors and microtubule-associated proteins. The dynamic instability of the MT cytoskeleton…
Cruzain (EC 3.4.22.51) is the major cysteine protease from Trypanosoma cruzi, the Chagas disease etiological agent. Due to its biological relevance, this enzyme is considered one of the most relevant targets to develop new anti-chagasics, which is urgent once the available therapy is old and very toxic due to a blend of unsatisfactory side effects and lack of efficacy. In this way, the st…
Cancer is the name of a group of devastating diseases characterized by uncontrolled growth and multiplication of abnormal cells capable of invading nearby structures and spread in various regions of the body. These malignant cells fail to respond to control and defense mechanisms of the body, continually doubling in a disorderly manner and causing tumors. The world scenario caused by deva…
| 1 / 1 | Ongoing research grants |
| 7 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 28 / 20 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 44 / 32 | All research grants and scholarships |
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CV Lattes
ORCID