CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Química Industrial from Universidade Federal de Santa Maria (1993), master's at Chemistry from Universidade Federal de Santa Catarina (1996) and ph.d. at Química Orgânica from Universidade Federal de Santa Catarina (1999). Has experience in Chemistry, acting on the following subjects: química medicinal, inibidores enzimáticos, relações entre a estrutura e a atividade (sar) and qsar. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| An agenda for forgotten diseases |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The lack of robustly validated drug targets has proved a significant barrier to the discovery of new treatments for visceral leishmaniasis and Chagas' disease. Furthermore, target deconvolution studies with active leads emerging from current small molecule phenotypic screening have confirmed that the same relatively few molecular targets are being hit repeatedly. This project aims to ad…
The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of C…
An International Cooperative Biodiversity Group (ICBG) with an interdisciplinary leadership team of physicians, pharmacologists, evolutionary biologists, and chemists will discover and develop therapeutic agents produced by Brazilian symbiotic bacteria. The team will target three therapeutic areas: 1) infectious fungal pathogens, 2) Chagas disease and leishmaniasis, and 3), cancers of the…
Cancer consists of a group of diseases characterized by the disordered growth of abnormal cells capable of invading numerous tissues and organs. The World Health Organization (WHO) considers it to be the second leading cause of death worldwide, being responsible for almost 10 million of deaths in 2018. Although chemotherapy relies on an important arsenal of drugs, treatments are associate…
Biodiversity provides exclusive chemical scaffolds for the design of active compounds and is the main source of drugs approved worldwide (67% are either a natural product, semi-synthetic derivative, macromolecule isolated from an organism or have a pharmacophore group inspired by natural products). Natural products are efficient models for medicinal chemistry because they comprise scaffol…
Pharmacokinetics (PK) is the study of the time course of drug absorption, distribution, metabolism and excretion (ADME), and how these ADME processes are related to the intensity and time course of the pharmacological (therapeutic and toxic) effects of drugs. Orally delivered pharmacologically active compounds must have favorable absorption and clearance properties and satisfactory metabo…
Chagas disease is a neglected tropical disease that affects millions of people worldwide, mainly in Latin America, where it is endemic. According to the World Health Organization, Chagas disease is a high priority condition for the development of novel therapies. The available drugs are obsolete, and have low efficacy and outstanding toxicity. In this context, the discovery of novel treat…
(Only some records are available in English at this moment)
Cruzain (EC 3.4.22.51) is the major cysteine protease from Trypanosoma cruzi, the Chagas disease etiological agent. Due to its biological relevance, this enzyme is considered one of the most relevant targets to develop new anti-chagasics, which is urgent once the available therapy is old and very toxic due to a blend of unsatisfactory side effects and lack of efficacy. In this way, the st…
Cancer is the name of a group of devastating diseases characterized by uncontrolled growth and multiplication of abnormal cells capable of invading nearby structures and spread in various regions of the body. These malignant cells fail to respond to control and defense mechanisms of the body, continually doubling in a disorderly manner and causing tumors. The world scenario caused by deva…
| 2 / 2 | Ongoing research grants |
| 5 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 20 / 12 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 32 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 14 |
| Citations | 78 |
| Cit./Article | 5.6 |
| Data from Web of Science | |
SALUM, LIVIA BARROS; VALADARES, NAPOLEAO FONSECA. Fragment-guided approach to incorporating structural information into a CoMFA study: BACE-1 as an example. Journal of Computer-Aided Molecular Design, v. 24, n. 10, p. 803-817, OCT 2010. Web of Science Citations: 8. (07/07294-9)
PAULI, IVANI; FERREIRA, LEONARDO G.; DE SOUZA, MARIANA L.; OLIVA, GLAUCIUS; FERREIRA, RAFAELA S.; DESSOY, MARCO A.; SLAFER, BRIAN W.; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors. Future Medicinal Chemistry, v. 9, n. 7, p. 641-657, MAY 2017. Web of Science Citations: 8. (13/25658-9, 13/07600-3, 11/13789-6)
DE FREITAS, LARISSA; VALLI, MARILIA; DAMETTO, ALESSANDRA C.; PENNACCHI, PAULA C.; ANDRICOPULO, ADRIANO D.; MARIA-ENGLER, SILVYA S.; BOLZANI, VANDERLAN S.. Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging. Journal of Natural Products, v. 83, n. 3, SI, p. 649-656, MAR 27 2020. Web of Science Citations: 1. (19/05967-3, 13/07600-3, 14/50926-0)
ALTEI, WANESSA F.; PACHANE, BIANCA C.; MARTINS, LUCIMARA J.; GOMES, RALPH C.; SANTOS, RICARDO N.; FERNANDES, DANIARA C.; SELISTRE-DE-ARAUJO, HELOISA S.; COELHO, FERNANDO; ANDRICOPULO, ADRIANO D.. Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple-Negative Breast Cancer Cell Migration. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 21, n. 14, p. 1901-1910, 2021. Web of Science Citations: 0. (13/07600-3, 19/11437-7, 10/06741-4)
ASSE JUNIOR, LEONARDO RANDER; KRONENBERGER, THALES; MAGALHAES SERAFIM, MATEUS SA; SOUSA, YAMARA VIANA; FRANCO, ISABELLA DRUMOND; VALLI, MARILIA; BOLZANI, VANDERLAN DA SILVA; MONTEIRO, GUSTAVO CLARO; BRUNO PRATES, JOAO LUCAS; KROON, ERNA GEESSIEN; et al. Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors. Future Medicinal Chemistry, v. 12, n. 1, p. 51-68, JAN 2020. Web of Science Citations: 0. (19/05967-3, 14/50926-0, 13/07600-3)
VALLI, MARILIA; ATANAZIO, LETICIA CRISTINA VIEIRA; MONTEIRO, GUSTAVO CLARO; COELHO, ROBERTA RAMOS; DEMARQUE, DANIEL PECORARO; ANDRICOPULO, ADRIANO DEFINI; ESPINDOLA, LAILA SALMEN; BOLZANI, VANDERLAN DA SILVA. The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control. Planta Medica, v. 87, n. 01/02, p. 6-23, FEB 2021. Web of Science Citations: 0. (14/50926-0, 13/07600-3, 19/05967-3)
VALLI, MARILIA; ATANAZIO, LETICIA CRISTINA VIEIRA; MONTEIRO, GUSTAVO CLARO; COELHO, ROBERTA RAMOS; DEMARQUE, DANIEL PECORARO; ANDRICOPULO, ADRIANO DEFINI; ESPINDOLA, LAILA SALMEN; BOLZANI, VANDERLAN DA SILVA. The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control. Planta Medica, v. 87, n. 01/02, DEC 2020. Web of Science Citations: 0. (13/07600-3, 19/05967-3, 14/50926-0)
DE PAULA NOGUEIRA CRUZ, FELIPE; FERREIRA DE PAULA, AILTON; NOGUEIRA, CAMILA TITA; MARQUES DE ANDRADE, PAULO HENRIQUE; BORGES, LEONARDO MAURICI; LACAVA, PAULO TEIXEIRA; BARATELLA DA CUNHA CAMARGO, ILANA LOPES; ANIBAL, FERNANDA DE FREITAS; PAIVA DE SOUSA, CRISTINA. Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects. INTERNATIONAL JOURNAL OF MICROBIOLOGY, v. 2021, FEB 17 2021. Web of Science Citations: 0. (13/07600-3, 16/13423-5, 19/04788-8)
MEDEIROS, ALEX R.; FERREIRA, LEONARDO L. G.; DE SOUZA, MARIANA L.; DE OLIVEIRA REZENDE JUNIOR, CELSO; ESPINOZA-CHAVEZ, ROCIO MARISOL; DIAS, LUIZ CARLOS; ANDRICOPULO, ADRIANO D.. Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors. BIOMOLECULES, v. 11, n. 4, APR 2021. Web of Science Citations: 0. (13/07600-3, 18/14268-9, 13/25658-9)
ZERAIK, MARIA LUIZA; PAULI, IVANI; DUTRA, LUIZ A.; CRUZ, RAQUEL S.; VALLI, MARILIA; PARACATU, LUANA C.; DE FARIA, CAROLINA M. Q. G.; XIMENES, VALDECIR F.; REGASINI, LUIS O.; ANDRICOPULO, ADRIANO D.; et al. Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Screening, Biochemical Evaluation and Molecular Modeling Studies. Molecules, v. 26, n. 8, APR 2021. Web of Science Citations: 1. (19/05967-3, 13/07600-3, 19/18445-5, 11/03017-6, 09/15457-0, 14/50926-0, 10/01506-7)
SILVA, AIRTON DAMASCENO; PEPE AMBROZIN, ALESSANDRA REGINA; DE CAMARGO, ANA FLAVIA S.; NOGUEIRA CRUZ, FELIPE DE PAULA; GOMES FERREIRA, LEONARDO LUIZ; KROGH, RENATA; SILVA, TAYNARA LOPES; BARATELLA DA CUNHA CAMARGO, ILANA LOPES; ANDRICOPULO, ADRIANO DEFINI; VIEIRA, PAULO CEZAR. Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites. Planta Medica, v. 87, n. 01/02, p. 187-195, FEB 2021. Web of Science Citations: 0. (14/50249-8, 19/04788-8, 13/07600-3)
FERREIRA, RAFAELA S.; DESSOY, MARCO A.; PAULI, IVANI; SOUZA, MARIANA L.; KROGH, RENATA; SALES, ANA I. L.; OLIVA, GLAUCIUS; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Synthesis, Biological Evaluation, and Structure-Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi Agents. Journal of Medicinal Chemistry, v. 57, n. 6, p. 2380-2392, MAR 27 2014. Web of Science Citations: 24. (10/16778-2, 12/02230-0, 13/07600-3)
DOS SANTOS, RICARDO N.; MORCOS, FARUCK; JANA, BIMAN; ANDRICOPULO, ADRIANO D.; ONUCHIC, JOSE N.. Dimeric interactions and complex formation using direct coevolutionary couplings. SCIENTIFIC REPORTS, v. 5, SEP 4 2015. Web of Science Citations: 29. (13/11950-0)
VALLI, MARILIA; ALTEI, WANESSA; DOS SANTOS, RICARDO N.; DE LUCCA, JR., EMILIO C.; DESSOY, MARCO A.; PIOLI, RENAN M.; COTINGUIBA, FERNANDO; CACHET, XAVIER; MICHEL, SYLVIE; FURLAN, MAYSA; et al. Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 475-484, MAR 2017. Web of Science Citations: 7. (13/07600-3, 10/17329-7, 03/02176-7, 10/06741-4)
(References retrieved automatically from State of São Paulo Research Institutions)
PAULI, Ivaní. Planejamento de inibidores da enzima cruzaína candidatos a fármacos para o tratamento da doença de Chagas. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (11/13789-6)
SANTOS, Ricardo Nascimento dos. Planejamento de moduladores de polimerização de microtúbulos com propriedades anticâncer, análise estrutural de macromoléculas e geração de uma base virtual de produtos naturais. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (10/06741-4)
MODA, Tiago Luiz. Modelagem In silico de propriedades farmacocinéticas para a avaliação de candidatos a novos fármacos. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (07/00440-0)
SALUM, Lívia de Barros. Planejamento de ligantes da tubulina com propriedades antitumorais. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (07/07294-9)
FERREIRA, Leonardo Luiz Gomes. Identificação de novos inibidores da enzima aldolase de Trypanosoma brucei. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (08/10727-7)
ALTEI, Wanessa Fernanda. Triagem biológica, identificação e planejamento de novos candidatos a agentes anticâncer a partir de produtos naturais e compostos sintéticos. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (09/15320-5)