Dr. Helder Nakaya is a senior researcher at the Hospital Israelita Albert Einstein and a part-time professor at the Faculty of Pharmaceutical Sciences of the University of São Paulo (USP). Co-founder and chief scientific officer of the Brazilian startup D2DNA and the Danish startup Synamics Therapeutics. He is also an adjunct professor at Emory University in Atlanta, United States, and was vice-director of FCF-USP. Member of the Deliberative Council of the Brazilian Society of Immunology and the board of the Brazilian Association of Bioinformatics and Computational Biology. He was an affiliate member of the Brazilian Academy of Sciences (ABC), a consultant to CEPI (Coalition for Epidemic Preparedness Innovations) and IUIS (International Union of Immunological Societies), and a member of the scientific advisory board of the European Ebola Vaccine Consortium and the International Institute for Applied Systems Analysis (IIASA). Computational Systems Biology lab website: www.csbiology.org (Source: Lattes Curriculum)
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Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project propo…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
Classical Swine Fever (CSF) is a contagious, hemorrhagic and often fatal disease of Suidae, such as pigs and wild boar, caused by the classical swine fever virus (CSFV). CSFV is an enveloped, single-stranded RNA virus that belongs to the Flaviviridae family (Moennig, 2000), distantly related for example to Zika and Yellow Fever virus. CSFV can be controlled by vaccination particularly usi…
The importance of statistics in natural sciences is unquestionable. Statistics is essential to analyze data appropriately and to reach reliable conclusions. However, little is known about formal statistical methods on graphs and their theoretical properties even with an increasing number of reports on the analysis of real world networks (e.g. functional brain networks, protein-protein int…
This project will foster an independently funded collaboration between laboratories of Dr. Thushan de Silva and Dr. Beate Kampmann at Imperial College London and Dr. Helder Nakaya's group (FCF-USP) at USP. By applying a cutting edge systems biology approach to integrate nasopharyngeal microbiome, mucosal and blood transcriptome, immunological and clinical data, we will identify and invest…
(Only some records are available in English at this moment)
Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project propo…
Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project propo…
This project aims to integrate genomic data of patients with Structural Biology, with the goal of predicting the efficacy of vacines at the individual level.Vaccines are essential in preventing infectious diseases and their effectiveness may vary between individuals due to genetic variations that affect the production of cytokines, signaling proteins involved in the immune response. Recen…
(Only some records are available in English at this moment)
Bipolar Affective Disorder (BD) is a very debilitating psychiatric condition characterized by the presence of depressive episodes and manic or hypomanic episodes that affect sexes in different ways, since female individuals tend to have a more depressive profile and rapid cycling, whereas males tend to have more manic episodes and a high rate of hospitalization due to mania. Previous resu…
Rheumatic autoimmune inflammatory diseases (RAIDs) is a group of inflammatory autoimmune diseases that affects primarily the connective tissues (Thomsen et al. 2020) and include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis and systemic scleroderma (Goldblatt and O'Neill 2013). These are a varied group of diseases in which the immune system r…
Inflammatory diseases constitute a complex and heterogeneous group of diseases, being an important cause of morbidity and mortality. In the present project, we intend to develop translational research in the area of Inflammatory Diseases. In addition, the association with chemists trained in molecular modeling and molecule synthesis will allow the development of new drugs to treat these d…
(Only some records are available in English at this moment)
The human microbiome has gained attention in recent years due to its involvement in both health and disease. Recent studies have found that some microbes may play an important role in the occurrence, progression, and prognosis of prostate cancer (PCa). Nonetheless, the impact of microbes on disease development remains complex and requires further investigation. Nowadays, RNA-Seq has becom…
The gut-brain axis is defined as the bidirectional communication between the brain and the microorganisms present in the gastrointestinal tract. This interaction modulates several brain functions, including behavior, through the production of neuroactive molecules and gene expression regulation. Therefore, disturbances in the gut microbiota are associated with behavior changes, immune dys…
Yellow Fever (YF) is a viral disease caused by the Yellow Fever virus (YFV). The treatment is supportive, and prevention is through mosquito control measures and vaccination with the Yellow Fever vaccine, YFV-17D. The YFV-17D is one of the most effective vaccines ever developed, providing 30-35 years of immunization with a single dose. Few studies have been conducted to investigate the im…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 19 / 19 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 37 / 37 | All research grants and scholarships |
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CV Lattes
ORCID