Dr. Helder Nakaya is an expert in computational systems biology, an emerging field that combines machine learning algorithms and omics data to understand and predict the behavior of human diseases. Dr. Nakaya was a professor at the University of São Paulo and deputy director of School of Pharmaceutical Sciences until 2021, when he became a senior researcher at the Hospital Israelita Albert Einstein in São Paulo. He is also an adjunct professor of the Department of Pathology at Emory University School of Medicine in US. Dr. Nakaya is an affiliate member of the Brazilian Academy of Sciences, principal investigator at the Center for Research in Inflammatory Diseases and at the Scientific Platform Pasteur-USP, consultant for CEPI (Coalition for Epidemic Preparedness Innovations) and IUIS (International Union of Immunological Societies), as well as member of the scientific advisory board of the European Ebola Vaccine Consortium and the International Institute of Applied Systems Analysis (IIASA). Laboratory website: https://www.csbiology.org/ (Source: Lattes Curriculum)
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Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project propo…
The importance of statistics in natural sciences is unquestionable. Statistics is essential to analyze data appropriately and to reach reliable conclusions. However, little is known about formal statistical methods on graphs and their theoretical properties even with an increasing number of reports on the analysis of real world networks (e.g. functional brain networks, protein-protein int…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
Classical Swine Fever (CSF) is a contagious, hemorrhagic and often fatal disease of Suidae, such as pigs and wild boar, caused by the classical swine fever virus (CSFV). CSFV is an enveloped, single-stranded RNA virus that belongs to the Flaviviridae family (Moennig, 2000), distantly related for example to Zika and Yellow Fever virus. CSFV can be controlled by vaccination particularly usi…
This project will foster an independently funded collaboration between laboratories of Dr. Thushan de Silva and Dr. Beate Kampmann at Imperial College London and Dr. Helder Nakaya's group (FCF-USP) at USP. By applying a cutting edge systems biology approach to integrate nasopharyngeal microbiome, mucosal and blood transcriptome, immunological and clinical data, we will identify and invest…
Infectious diseases caused by enteric pathogens are endemic specifically in developing countries, and are responsible for several thousands of deaths every year. This proposal will focus on enteric fever caused by Salmonella Typhi and Paratyphi as a model for intestinal infections. Typhoid fever significantly affects South America, sub-Saharan Africa and South-East Asia with approximately…
(Only some records are available in English at this moment)
Autoimmune inflammatory diseases are disorders in which aberrant immune response leads to tissue damage mediated by autoantibodies, leading to tissue destruction, disability and comorbidities. Autoimmune diseases affect ~5% of the population with substantial morbidity and decrease in functionality, including loss of work ability and other social consequences. Several molecular mechanisms …
The present work plan aims to extract phenotypic features of the parasite species Trypanosoma, Plasmodium and Leishmania in images derived from microscopy. Such features consist of curvature attributes (minimum, maximum, average, standard deviation, variance, entropy and potential energy), geometric (area, circularity, proportion, perimeter, maximum and minimum distances); and texture sta…
The Human Cell Atlas is an international effort aiming at characterizing every cell type of the human body. Employing techniques such as single-cell RNA sequencing, mass cytometry, and multiplexed in situ hybridization, it will produce data from virtually all human tissues. This wealth of data can have a significant impact on biomedical research, but only if its content is genuinely avail…
(Only some records are available in English at this moment)
Bipolar Affective Disorder (BD) is a very debilitating psychiatric condition characterized by the presence of depressive episodes and manic or hypomanic episodes that affect sexes in different ways, since female individuals tend to have a more depressive profile and rapid cycling, whereas males tend to have more manic episodes and a high rate of hospitalization due to mania. Previous resu…
Rheumatic autoimmune inflammatory diseases (RAIDs) is a group of inflammatory autoimmune diseases that affects primarily the connective tissues (Thomsen et al. 2020) and include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis and systemic scleroderma (Goldblatt and O'Neill 2013). These are a varied group of diseases in which the immune system r…
Inflammatory diseases constitute a complex and heterogeneous group of diseases, being an important cause of morbidity and mortality. In the present project, we intend to develop translational research in the area of Inflammatory Diseases. In addition, the association with chemists trained in molecular modeling and molecule synthesis will allow the development of new drugs to treat these d…
(Only some records are available in English at this moment)
The human microbiome has gained attention in recent years due to its involvement in both health and disease. Recent studies have found that some microbes may play an important role in the occurrence, progression, and prognosis of prostate cancer (PCa). Nonetheless, the impact of microbes on disease development remains complex and requires further investigation. Nowadays, RNA-Seq has becom…
The gut-brain axis is defined as the bidirectional communication between the brain and the microorganisms present in the gastrointestinal tract. This interaction modulates several brain functions, including behavior, through the production of neuroactive molecules and gene expression regulation. Therefore, disturbances in the gut microbiota are associated with behavior changes, immune dys…
Yellow Fever (YF) is a viral disease caused by the Yellow Fever virus (YFV). The treatment is supportive, and prevention is through mosquito control measures and vaccination with the Yellow Fever vaccine, YFV-17D. The YFV-17D is one of the most effective vaccines ever developed, providing 30-35 years of immunization with a single dose. Few studies have been conducted to investigate the im…
Metabolic Syndrome (MS) comprises a broad range of diseases in which immunometabolism and inflammation have a great influence. The increasing prevalence of obesity and MS has lead researchers investigate their influence in chronic inflammatory diseases. Despite this, little is known about the molecular pathways and gene networks that are in common between MS and inflammatory diseases. To …
| 3 / 3 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 33 / 33 | All research grants and scholarships |
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