Gabriel Forato Anhê

• Abstract

  The allergic airway disease (AAD) is hallmarked by a predominant Th2 inflammatory response with eosinophil and neutrophils infiltration into the lung parenchyma. Landmark studies published by Dr Page and Dr Riffo-Vasquez collected evidence to support the notion that leukocyte recruitment to the lung induced by allergic inflammation is dependent on platelet-leukocyte interaction. In our la…

  Influence of airway allergic inflammation on platelet infiltration in the lungs of mice consuming hyperlipidic diet or sucrose consumption: possible participation of gut microbiota, AV.EXT

• Abstract

  Obesity is a highly prevalent condition that associates the positive energy balance with a chronic subclinical inflammatory state characterized by elevated levels of TNF± and IL-6 and increased infiltration of M1 macrophages in white adipose tissue. The exacerbation of the TH2 inflammatory response of allergic asthma is another characteristic observed in obese humans and mice. Some adapta…

  Transitory history of obesity during different moments of life and its impact on allergy airway disease, AP.R

• Abstract

  Background: Caloric restriction (CR) of 50% during pregnancy and lactation may raise maternal corticosterone levels and relative adrenal weight. This corticosterone excess programs long-term consequences in the offspring such as increased arterial stiffness and glucose intolerance. Interestingly, the phenotype programming originated by caloric restriction is partially prevented by treatin…

  Effects of PPAR-gamma or PPAR-alpha agonists on the metabolic programming induced by maternal caloric restriction during pregnancy and lactation, AP.R

(Only some records are available in English at this moment)

• Abstract

  Several studies linked depression as an independent risk factor for the onset of cardiovascular disease. One reason for this correlation is the exacerbation of platelet activity described in patients diagnosed with Major Depressive Disorder (MDD). Among the therapeutic possibilities for depressed patients, selective serotonin reuptake inhibitors (SSRIs) demonstrate anti-aggregating abilit…

  The effect of agomelatine in human platelets aggregation and adhesion, BP.MS

• Abstract

  Obesity is characterized by an overgrowth of adipose tissue, which a negative impact on health and is highly present throughout the world, being capable of causing dozens of associated diseases such as diabetes, hypertension and cancer. Asthma, in turn, is a chronic inflammatory disease of the airways resulting in limited air passage into the lungs, being reversible spontaneously or throu…

  Influence of the history of Obesity originated at different moments of life in allergic pulmonary inflammation, BP.PD

• Abstract

  Corticotherapy during pregnancy demonstrates a relative success in reducing mortality and distress respiratory syndrome incidence in the pre-term newborn. In spite of these immediate benefits, it has been described that babies born to betamethasone-treated mothers develop increased cardiovascular risk at the adolescence. Attempting to evaluate whether this cardiovascular risk can be assoc…

  Evaluation of the long-term changes in the lipid profile of woman that underwent antenatal corticotherapy during pregnancy, BP.IC

(Only some records are available in English at this moment)

• Abstract

  We and others have demonstrated that obese mice subjected to the model of sensitization and challenge with ovalbumin (OVA) display increased lung eosinophil infiltration and elevated production of TH2 cytokines when compared to lean littermates. Apart of these consistent studies, it still remains to be described the precise mechanism by which obesity is linked to asthma exacerbation. Patt…

  Participation of NOD1, NOD2 and Ripk2 in the exacerbation of allergic airway disease associated to obesity, BE.EP.PD

• Abstract

  Recent epidemiological data reveled that excessive consumption of fructose-sweetened beverages correlate with a higher risk for asthma in infants and adults. To date, however, no experimental evidence supports that fructose consumption exacerbates inflammatory response in allergic asthma. The latter is hallmarked by a predominant TH2 activation in which key cytokines, such as IL-4, IL-5, …

  Investigating the impact of fructose consumption on the airway inflammatory response during allergic asthma: focus on the gut microbiota, BE.PQ

• Abstract

  Obesity is a serious and growing metabolic disorder, it is estimated that over 30% of the world's population is overweight. This condition can lead to the development of many diseases including hypertension, diabetes, apnea and asthma. Regarding asthma, an inflammatory disease of the respiratory system, this presents several causes, such as allergens, drugs and obesity. Affecting about 18…

  Influence of sexual gender on allergic lung inflammation in normolipidic and hyperlipidic mice exposed to ovalbumin, BE.EP.DR

(Only some records are available in English at this moment)