CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Farmácia-Bioquímica from Universidade de São Paulo (2005) and ph.d. at Pós-Graduação em Fisiologia Humana from Instituto de Ciências Biomédicas da Universidade de São Paulo (2007). Has experience in Physiology, focusing on Endocrinal Physiology, acting on the following subjects: secreção de insulina. (Source: Lattes Curriculum)
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The allergic airway disease (AAD) is hallmarked by a predominant Th2 inflammatory response with eosinophil and neutrophils infiltration into the lung parenchyma. Landmark studies published by Dr Page and Dr Riffo-Vasquez collected evidence to support the notion that leukocyte recruitment to the lung induced by allergic inflammation is dependent on platelet-leukocyte interaction. In our la…
Obesity is a highly prevalent condition that associates the positive energy balance with a chronic subclinical inflammatory state characterized by elevated levels of TNF± and IL-6 and increased infiltration of M1 macrophages in white adipose tissue. The exacerbation of the TH2 inflammatory response of allergic asthma is another characteristic observed in obese humans and mice. Some adapta…
Background: Caloric restriction (CR) of 50% during pregnancy and lactation may raise maternal corticosterone levels and relative adrenal weight. This corticosterone excess programs long-term consequences in the offspring such as increased arterial stiffness and glucose intolerance. Interestingly, the phenotype programming originated by caloric restriction is partially prevented by treatin…
Several medical studies demonstrate that the duration of breastfeeding period exert a long-term impact on maternal metabolism. Generally, the duration of breastfeeding has an inverse correlation with the relative risk to the development of metabolic syndrome and Type 2 Diabetes. Specifically, mothers who breastfeed for less than 3 months display high LDL and low HDL levels, high levels of…
(Only some records are available in English at this moment)
Several studies linked depression as an independent risk factor for the onset of cardiovascular disease. One reason for this correlation is the exacerbation of platelet activity described in patients diagnosed with Major Depressive Disorder (MDD). Among the therapeutic possibilities for depressed patients, selective serotonin reuptake inhibitors (SSRIs) demonstrate anti-aggregating abilit…
Obesity is characterized by an overgrowth of adipose tissue, which a negative impact on health and is highly present throughout the world, being capable of causing dozens of associated diseases such as diabetes, hypertension and cancer. Asthma, in turn, is a chronic inflammatory disease of the airways resulting in limited air passage into the lungs, being reversible spontaneously or throu…
Corticotherapy during pregnancy demonstrates a relative success in reducing mortality and distress respiratory syndrome incidence in the pre-term newborn. In spite of these immediate benefits, it has been described that babies born to betamethasone-treated mothers develop increased cardiovascular risk at the adolescence. Attempting to evaluate whether this cardiovascular risk can be assoc…
(Only some records are available in English at this moment)
We and others have demonstrated that obese mice subjected to the model of sensitization and challenge with ovalbumin (OVA) display increased lung eosinophil infiltration and elevated production of TH2 cytokines when compared to lean littermates. Apart of these consistent studies, it still remains to be described the precise mechanism by which obesity is linked to asthma exacerbation. Patt…
Recent epidemiological data reveled that excessive consumption of fructose-sweetened beverages correlate with a higher risk for asthma in infants and adults. To date, however, no experimental evidence supports that fructose consumption exacerbates inflammatory response in allergic asthma. The latter is hallmarked by a predominant TH2 activation in which key cytokines, such as IL-4, IL-5, …
Obesity is a serious and growing metabolic disorder, it is estimated that over 30% of the world's population is overweight. This condition can lead to the development of many diseases including hypertension, diabetes, apnea and asthma. Regarding asthma, an inflammatory disease of the respiratory system, this presents several causes, such as allergens, drugs and obesity. Affecting about 18…
Increasing evidence from studies in humans and animal models suggests that maternalobesity during pregnancy can, through non-genetic mechanisms, increase the risk ofcardiovascular dysfunction, insulin resistance, type 2 diabetes and other features of themetabolic syndrome in the offspring. However, the components of the in uteroenvironment that mediate the effects of maternal obesity on o…
| 2 / 2 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 25 / 22 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 38 / 33 | All research grants and scholarships |
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