Patrícia de Oliveira Prada
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas (FCA) (Institutional affiliation for the last research proposal) Birthplace: Brazil
She was graduated in Nutrition from the University of the State of Rio de Janeiro (UERJ). She did a Specialization in Nutrition Area at Santa Casa de Misericórdia in Rio de Janeiro and a Residency in Nutrition at Pedro Ernesto University Hospital (Rio de Janeiro). She holds a Ph.D. in Science from the University of São Paulo (USP). She was a postdoctoral fellowship in the clinical research laboratory in insulin resistance at the School of Medical Sciences of UNICAMP from 2002 to 2006 and a postdoctoral fellowship at the Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess Medical Center (BIDMC)/Harvard Medical School in Boston from 2006 to 2009. She is currently Professor of Nutrition at the School of Applied Sciences (FCA) of UNICAMP at the Campus of Limeira, São Paulo, where she coordinates the Laboratory of Molecular Research in Obesity (LabIMO). Her research line is about the identification and understanding of the physiological, pathophysiological, and molecular mechanisms that control food intake. In this line, she has international publications that have identified signaling proteins in the hypothalamus and reward system that participate in the control of food intake, contributing to the genesis of obesity. She has international publications demonstrating the importance of the gut microbiota in the regulation of body weight and food intake. Also, she has ongoing research projects that investigate possible pathophysiological and molecular mechanisms involved in the management of food intake in the face of environmental challenges, such as consumption of very palatable diets (cafeteria diet) and exposure to air pollution. (Source: Lattes Curriculum)
- The specific deletion of CLK2 in GABA neurons: the impact on feeding behavior and energy metabolism in mice, AP.R
Abstract
Obesity has been exponentially increasing in the last decades, making urgent to understand the underlying mechanisms contributing to its development, maintenance and associated comorbidities. The maintenance of energetic homeostasis is under the control of endocrine hormones and neural signals. The hormones, insulin and leptin, are the most investigated in central energy regulation, as ...
- Impact of the perinatal exposure to environmental pollutants in the genesis of obesity and type 2 diabetes mellitus: metabolic and epigenetic aspects, AP.R
Abstract
Exposure to air pollution has been highlighted as an important risk factor for morbidity and mortality in the world. Several pollutants, such as particulate matter weighing d 2.5 ¼m (MP2.5), as well as one of its chemical compounds, 1,2-naphthoquinone (1,2-NQ), obtained by burning diesel, have been associated with the genesis of chronic diseases, including type 2 diabetes mellitus (T2D)...
- International Congress of neuroendocrinology, AR.EXT
- The effect of obesity in the regulation of AMPK in the amygdala: implications on energy metabolism, AP.R
Abstract
Obesity is now one of the most important public health problems in the world, the most important risk factor for the development of various comorbidities. Body weight is maintained through a balance between food intake and energy expenditure. The increased activity of AMP-activated protein kinase (AMPK) in hypothalamic nuclei is associated with increased food intake. In recent years, ot...
- Keystone Symposia on Molecular and Cellular Biology, AR.EXT
(Only some records are available in English at this moment)
- Impact of the perinatal exposure to environmental pollutants in the genesis of obesity and diabetes mellitus type 2: metabolic and epigenetic aspects, BP.PD
Abstract
Exposure to air pollution has been highlighted as an important risk factor for morbidity and mortality in the world. Several pollutants, such as particulate matter with diameter d 2.5 ¼m (MP2.5), as well as one of its chemical compounds, 1,2-naphthoquinone (1,2-NQ), obtained by burning diesel, have been associated with the genesis of chronic diseases, including type 2 diabetes mellitus ...
- Study of the effects of atmospheric pollution on obesity genesis: the role of HYPOTALAMIC toll like receptor 4 activation, BP.IC
Abstract
Long-term exposure to air pollution may have unfavorable effects on health. Particulate matter (PM) diameter less than or equal to 2.5 µm (PM2.5) is associated with the induction of chronic inflammation. Obesity may be a consequence of the imbalance between food consumption and energy expenditure. JAK2 / STAT3 pathway in hypothalamic nuclei is an important hallmark of leptin signaling a...
- Study of AMPK regulation activity in amygdala from control animals and possible effects on food intake and energy expenditure, BP.DR
Abstract
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that regulates cellular and whole body energy balance. Several studies have shown that hypothalamic AMPK participates in the control of food intake in response to nutrients and hormones such as insulin, leptin and ghrelin. The increase in AMPK activity in hypothalamus is associated with increased food intake and i...
- Study of molecular mechanisms involved in the reduction of obese rodents treated with liraglutide, BP.MS
Abstract
The type 2 diabetes mellitus (T2DM) has become a serious and growing public health problem, affecting both developed and developing countries. Installation is associated with obesity and insulin resistance. Liraglutide represents a class of injectable drugs for the treatment of T2DM known as incretino-mimetic which exhibit similar effects to human incretin hormone called glucagon-like p...
(Only some records are available in English at this moment)
- The role of neuronal Cdc-2-Like kinase 2 (Clk2) in the modulation of energy balance, BE.EP.DR
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival and the hypothalamus plays an important role in the regulation of whole-body energy balance by integrating nutrient and hormone signals from peripheral inputs. Insulin and leptin are hormones that though their intracellular signaling control food intake and energy expenditure stimula...
| 2 / 2 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 15 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 18 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 171 |
| Cit./Article | 15.5 |
| Data from Web of Science | |
ZECCHIN, H. G.; GASPARETTI, A. L.; TORSONI, M. A.; UENO, M.; HIRATA, A. E.; AMARAL, M. E. C. DO; HÖER, N. F.; BOSCHERO, A. C.; SAAD, M. J. A.; PRADA, P. DE O.. Western diet modulates insulin signaling, c-jun n-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology, v. 146, n. 3, p. 1576-1587, Dec. 2004.
PRADA‚ P.O.; OKAMOTO‚ M.M.; FURUKAWA‚ L.N.S.; MACHADO‚ U.F.; HEIMANN‚ J.C.; DOLNIKOFF‚ M.S.. High-or low-salt diet from weaning to adulthood: effect on insulin sensitivity in Wistar rats. Hypertension, v. 35, n. 1, p. 424-429, 2000.
CONDES AREIAS, MARIA FERNANDA; PRADA, PATRICIA OLIVEIRA. Mechanisms of insulin resistance in the amygdala: Influences on food intake. Behavioural Brain Research, v. 282, p. 209-217, APR 2015. Web of Science Citations: 23. (12/10338-6, 13/07607-8)
WEISSMANN, LAIS; QUARESMA, PAULA G. F.; SANTOS, ANDRESSA C.; DE MATOS, ALEXANDRE H. B.; PASCOAL, VINICIUS D'AVILA BITTENCOURT; ZANOTTO, TAMIRES M.; CASTRO, GISELE; GUADAGNINI, DIOZE; DA SILVA, JOELCIMAR MARTINS; VELLOSO, LICIO A.; et al. IKK epsilon Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity. Diabetes, v. 63, n. 10, p. 3334-3345, OCT 2014. Web of Science Citations: 20. (12/10338-6, 13/07607-8, 10/52068-0)
CASTRO, GISELE; AREIAS, MARIA FERNANDA C.; WEISSMANN, LAIS; QUARESMA, PAULA G. F.; KATASHIMA, CARLOS K.; SAAD, MARIO J. A.; PRADA, PATRICIA O.. Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS OPEN BIO, v. 3, p. 443-449, 2013. Web of Science Citations: 37.
PRADA, PATRICIA O.; QUARESMA, PAULA G. F.; CARICILLI, ANDREA M.; SANTOS, ANDRESSA C.; GUADAGNINI, DIOZE; MORARI, JOSEANE; WEISSMANN, LAIS; ROPELLE, EDUARDO R.; CARVALHEIRA, JOSE BARRETO C.; VELLOSO, LICIO A.; et al. RETRACTED: Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei(Retracted article. See vol. 66, pg. 785, 2017). Diabetes, v. 62, n. 1, p. 137-148, JAN 2013. Web of Science Citations: 24.
QUARESMA, P. G. F.; REENCOBER, N.; ZANOTTO, T. M.; SANTOS, A. C.; WEISSMANN, L.; DE MATOS, A. H. B.; LOPES-CENDES, I.; FOLLI, F.; SAAD, M. J. A.; PRADA, P. O.. Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. International Journal of Obesity, v. 40, n. 1, p. 138-146, JAN 2016. Web of Science Citations: 11. (12/10338-6, 13/07607-8)
PRADA, PATRICIA O.; SAAD, MARIO J. A.. Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes. EXPERT OPINION ON INVESTIGATIONAL DRUGS, v. 22, n. 6, p. 751-763, JUN 2013. Web of Science Citations: 1. (12/10338-6)
QUARESMA, P. G. F.; WEISSMANN, L.; ZANOTTO, T. M.; SANTOS, A. C.; DE MATOS, A. H. B.; FURIGO, I. C.; SIMABUCO, F. M.; DONATO, JR., J.; BITTENCOURT, J. C.; LOPES-CENDES, I.; et al. Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis. International Journal of Obesity, v. 41, n. 2, p. 268-278, FEB 2017. Web of Science Citations: 4. (12/10338-6, 13/07607-8, 15/00343-0)
CARICILLI, ANDREA M.; PENTEADO, ERICA; DE ABREU, LELIA L.; QUARESMA, PAULA G. F.; SANTOS, ANDRESSA C.; GUADAGNINI, DIOZE; RAZOLLI, DANIELLA; MITTESTAINER, FRANCINE C.; CARVALHEIRA, JOSE B.; VELLOSO, LICIO A.; et al. Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in Mice. Endocrinology, v. 153, n. 9, p. 4401-4411, SEP 2012. Web of Science Citations: 25.
MENDES, NATALIA FERREIRA; CASTRO, GISELE; GUADAGNINI, DIOZE; TOBAR, NATALIA; COGNUCK, SUSANA QUIROS; KAGOHARA ELIAS, LUCILA LEICO; BOER, PATRICIA ALINE; PRADA, PATRICIA OLIVEIRA. Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 70, p. 1-11, MAY 2017. Web of Science Citations: 7. (13/07607-8, 15/00343-0)
ZAMBOM DE SOUZA, ALESSANDRA ZANIN; ZAMBOM, ADRIANO ZANIN; ABBOUD, KAHLILE YOUSSEF; REIS, SABRINA KAREN; TANNIHAO, FABIANA; GUADAGNINI, DIOZE; SAAD, MARIO J. A.; PRADA, PATRICIA OLIVEIRA. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. NUTRITION, v. 31, n. 6, p. 884-889, JUN 2015. Web of Science Citations: 19. (12/10338-6, 13/07607-8)
ABBOUD, KAHLILE YOUSSEF; REIS, SABRINA KAREN; MARTELLI, MARIA EDUARDA; ZORDAO, OLIVIA PIZETTA; TANNIHAO, FABIANA; DE SOUZA, ALESSANDRA ZANIN ZAMBOM; ASSALIN, HELOISA BALAN; GUADAGNINI, DIOZE; ROCHA, GUILHERME ZWEIG; SAAD, MARIO JOSE ABDALLA; et al. Oral Glutamine Supplementation Reduces Obesity, Pro-Inflammatory Markers, and Improves Insulin Sensitivity in DIO Wistar Rats and Reduces Waist Circumference in Overweight and Obese Humans. NUTRIENTS, v. 11, n. 3, MAR 1 2019. Web of Science Citations: 0. (17/18498-6)
(References retrieved automatically from State of São Paulo Research Institutions)
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CASTRO, Gisele de. Obesidade induzida por dieta desencadeia estresse do retículo endoplasmático e resistência à insulina em amígdala de ratos. 2013. Dissertação (Mestrado) - Faculdade de Ciências Aplicadas. Universidade Estadual de Campinas (UNICAMP). (11/15013-5)
CASTRO, Gisele de. A regulação da proteína quinase ativada pelo AMP (AMPK) no CeA e os efeitos sobre o controle da ingestão alimentar e gasto energético. 2017. Tese (Doutorado) – Universidade Estadual de Campinas, Faculdade de Ciências Médicas. (14/16724-0)
WEISSMANN, Laís. A serina quinase IKK epsilon (IKKe) é importante para a ação e sinalização da insulina e leptina no hipotálamo de camundongos obesos. 2013. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (11/02289-2)
AREIAS, Maria Fernanda Condes. Insulin action/signaling in amygdala of controls and obeses animals : effects on food intake, inflammation and ER stress = Regulação da ação e sinalização de insulina em amígdala de animais controles e obesos : efeitos na ingestão alimentar, via inflamatória e stress de retículo endoplasmático. 2012. Tese (Doutorado) – Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (11/17673-2)
BERGONSI, Paula Gabriele Fernandes Quaresma. Proteína CLK2 (Cdc-2-like kinase 2) no hipotálamo é importante para a manutenção da homeostase energética. 2017. Tese (Doutorado) – Universidade Estadual de Campinas, Faculdade de Ciências Médicas. (12/10058-3)