CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
I graduated in Medicine from the Federal University of Rio Grande do Norte (UFRN) in 1992 and served as a Medical Lieutenant in the Brazilian Army in 1993. I completed a residency in Internal Medicine at SUS-Hospital Heliópolis in 1994, followed by another residency in Internal Medicine in 1995 and in Endocrinology and Metabolism from 1996 to 1998, all at the Escola Paulista de Medicine (EPM) of the Federal University of São Paulo (Unifesp). I obtained my Master's degree (CAPES, 2000) and Doctorate (FAPESP, 2004) in Medicine, with a focus on Clinical Endocrinology, from EPM/Unifesp. My Sandwich Doctorate (PDEE) was conducted at the Eccles Institute of Human Genetics at the University of Utah, USA, in 2003, where I studied the genetic basis of Thyrotoxic Periodic Paralysis, identifying genetic variants in a new potassium channel (Kir2.6) in genetically susceptible patients. After that, I pursued a Post-Doctorate in Developmental Biology at the University of California, San Francisco, from 2004 to 2006. I served as co-editor of the Archives of Endocrinology and Metabolism from 2007 to 2010 and as vice-president of the Basic Endocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) from 2009 to 2011. I also held the position of vice-chair of the Biochemistry Department at EPM/Unifesp from 2010 to 2011. In 2015, I became a Full Professor (Livre Docente) in the Discipline of Endocrinology at the Department of Medicine. Since 2011, I have been the chief preceptor of the Adolescent-Adult Transition Endocrinology outpatient clinic at Hospital São Paulo (HSP)/University Hospital (HU) of EPM/Unifesp. I have coordinated various research projects in Molecular and Translational Endocrinology, currently focused on Differences of Sex Development (DSD) and health promotion for the Intersex population. In 2017, we founded the Study, Research, Extension, and Assistance Center for Trans People, Professor Roberto Farina (TransUnifesp Center / NTU), of which I was the coordinator until 2021. I served as Adjunct Pro-Rector for Extension and Culture at Unifesp from 2017 to 2021. Currently, I coordinate the Human Identification Laboratory (LabIH) at the Center for Forensic Archaeology and Anthropology (CAAF/Unifesp) and continue as the preceptor for multidisciplinary and transdisciplinary care for Trans and Intersex individuals in outpatient clinics linked to HU/HSP. Additionally, I have supervised undergraduate research students, Master's, Doctoral, and Post-Doctoral students related to the graduate programs in Molecular Biology (CAPES 7) and Endocrinology and Metabolism (CAPES 5). I was a member of the University Council and the Congregation of EPM/Unifesp from 2021 to 2023, and I was elected director of EPM/Unifesp for the 2023-2027 term. (Source: Lattes Curriculum)
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Multiple Endocrine Neoplasia type 2 (MEN2) is an autosomal dominant genetic syndrome caused by germline mutations in the RET gene and represented by associations of tumors of endocrine origin, among which stands out the high penetration of medullary thyroid carcinoma (MTC). It is a complex and multifaceted disease that requires a multidisciplinary approach. Our group has contributed to th…
Sex determination in humans is established from the balance of signaling pathways that act in parallel and antagonistically. The pro-testicular pathways pass through the SRY gene's activation, which is a trigger factor for forming the testis. Evidence has suggested the existence of a genetic module for ovarian determination, which is probably composed of more than one factor that acts as …
The prevalence of thyroid nodules depends on several factors such as age, population studied, sex and method of evaluation. Due to the use of high-resolution ultrasound, which can detect nodules as small as 2 mm, the prevalence of thyroid nodules has increased, reaching up to 67 %. As a consequence of the increase in the diagnosis of the nodules, we also observed an increased incidence of…
(Only some records are available in English at this moment)
Medullary Thyroid Carcinoma (MTC) is a neuroendocrine tumor originating from thyroid parafollicular cells, also called C cells, which secrete calcitonin. MTC accounts for 5% of thyroid cancers. Most cases of MTC are sporadic, and approximately 30% are associated with a hereditary syndrome called multiple endocrine neoplasia type 2 (MEN2A and MEN2B). In these syndromes, MTC is the most fre…
Thyrotoxic Periodic Paralysis (TPP) is the clinical condition characterized by sudden and reversible loss of muscle strength associated with thyrotoxicosis and hypokalemia. TPP is the most frequent of acquired acute flaccid paralysis in young male and is more prevalent in Asian and Latin American population. We have recently known that TPP is the newest form of endocrine channelopathy co…
Epigenetic modifications are defined as heritable changes in gene expression that are not accompanied by changes in the nucleotide sequence of DNA. The relationship between epigenetic mechanisms and tumorigenesis was first verified through of whole genome hypomethylation in carcinomas. Abnormal methylation appears to play an important role in differentiated thyroid carcinomas derived from…
(Only some records are available in English at this moment)
MTC, a relatively uncommon form of cancer originating from the parafollicular C-cells of the thyroid, accounts for approximately 2-8% of thyroid cancers1. Activating mutations in the RET receptor tyrosine kinase gene are common in MTC, and KRAS or HRAS mutations also occur. Remarkably, in a recent whole exome sequencing study, no other driver mutations were identified recurrently in MTC,…
| 1 / 1 | Ongoing grants |
| 5 / 5 | Completed research grants |
| 7 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 12 | All research grants and scholarships |
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