CV Lattes
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Biologia from Faculdade de Filosofia Ciencias e Letras (1958) and doctorate at Nefrology from Universidade de São Paulo (1969). Has experience in Physiology, focusing on Renal Physiology, acting on the following subjects: fisiologia renal, ph intracelular, aldosterona, acidificacao renal and h-atpase. (Source: Lattes Curriculum)
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The sub-projects outlined in the present Thematic Project proposal all involve studying the transport of ions through cell membranes. With the exception of two that analyze 1) other aspects of glomerular cells and 2) the transport of the neutral molecule NH3 through cells involved with ammonia ammonia (NH3/NH4+) homeostasis or transport, such as the hepatocytes and collecting duct cells. …
This thematic project includes projects having in common the study of ion transporters in membranes. Most of these projects focalize the study of epithelial cells of the kidney, with the exception of two, which analyze glial neurons/cells and osteoclasts. In neurons, the effect of phenylpropenes on voltage sensitive sodium channels will be investigated, and in glial cells, purinergic meta…
The general object of this project is the investigation of the molecular and functional mechanisms of ion transport in cells, particularly of the epithelial type, originating from renal and other tissues. Among the methods that will be used for this purpose are renal micropuncture and microperfusion, molecular biology including transfection of wild type and mutant transporters into cultur…
(Only some records are available in English at this moment)
The actions of Ang-(1-7) in the kidney are not well understood: some admit they may be via receptor MAS and others via Mas plus AT1 and/or AT2. In our recent Master (see attached work), we demonstrated that in the proximal tubule Ang-(1-7), via MAS, has a biphasic effect: low dose inhibits the Na+/H+ exchanger (NHE3 isoform) increasing a lot the [Ca2+]i and high doses stimulates the excha…
| 11 / 8 | Completed research grants |
| 9 / 1 | Completed scholarships in Brazil |
| 20 / 9 | All research grants and scholarships |
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