CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Farmácia Bioquímia from Universidade Federal do Paraná (1999) and doctorate at Pharmacology from Universidade de São Paulo (2004). Has experience in Pharmacology, focusing on Psychopharmacology, acting on the following subjects: antidepressant, cannabinoids, nitric oxide, stress and neuroplasticity. (Source: Lattes Curriculum)
The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, p…
Several studies indicate that inhibition of nitric oxide (NO) induces antidepressant-like effects in animal models. Recent evidence from our research group suggest that the inducible isoform of NO synthase (iNOS) plays an important role in regulating the production of NO during exposure to stress, since its pharmacological inhibition or its gene expression (knockout, KO) induces antidepre…
In the last 15 years our group has contributed to a better understanding of the role of nitric oxide (NO) and endocannabinoids (eCBs) in physiological and pathophysiological processes of the central nervous system. We showed that manipulations of these atypical neurotransmitters are able to change behavioral and autonomic responses of laboratory animals submitted to animal models of anxie…
Recent studies indicate that epigenetic mechanisms migh be involved in the neurobiology of depression. For example, DNA methylation, which is associated with transcriptional repression, is increased by exposure to stress. Besides, high levels of methylation in specific gene loci were found in the brains of suicide victims. In addition, preliminary results of our research group showed that…
(Only some records are available in English at this moment)
Depression is a debilitating psychiatric disorder. Antidepressants have limitations on their use, such as the delay of four to six weeks for onset of therapeutic action and inefficiency in 30-45% of patients.Among the substances that present a better therapeutic profile are cannabidiol (CBD), which showed a rapid and sustained antidepressant effect in animal models. The mechanisms respons…
Depression is a recurrent, long-lasting and disabling mental disorder that, despite efforts to comprehend its neurobiology, still lacks sufficiently effective treatments that quickly induces effect. Among the various neurobiological changes inherent to this disorder, a decrease in gabaergic neurotransmission seems to be involved in the etiology of depression. Indeed, treatment with alpraz…
Several evidence suggests that repeated exposure to cocaine promotes structural and electrophysiological modifications in encephalic mesolimbic pathway, that result in behavioral changes related to abuse. These neural adaptations may be due to modulation of gene expression, which are critically regulated by epigenetic mechanisms. Recently, the influence of these regulatory mechanisms in m…
(Only some records are available in English at this moment)
Depression is a debilitating and disabling psychiatric disorder. Dysfunction on pre-frontal cortex (PFC) have been related to depression. Ketamine is an important drug that produces rapid and sustained antidepressant effects, which seems to involve activation of the BDNF-TrkB-mTOR pathway, with subsequent activation of MEK and PI3K, leading to increased synaptogenesis. We have recently sh…
Repeated exposure to cocaine promotes structural and electrophysiological changes in the mesolimbic encephalic pathway, which regulates behaviors related to abuse. These complex adaptations in the brain are mediated by dynamic patterns of gene expression that are translated into enduring changes critically regulated by epigenetics mechanisms, including histone acetylation. Indeed, recent …
The majority of major depression (MD) is preceded by stressful events. The stress leads to an increase in glutamate release, synthesis and release of nitric oxide (NO) as well as epigenetic changes induced by increased DNA methylation in the promoter regions of genes involved in the pathophysiology of MD. It has been demonstrated that oxidative stress and NO can modulate mediators respons…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 19 / 18 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 31 / 30 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 29 |
| Citations | 269 |
| Cit./Article | 9.3 |
| Data from Web of Science | |
SCOPINHO, AMERICA A.; LISBOA, SABRINA F. S.; GUIMARAES, FRANCISCO S.; CORREA, FERNANDO M. A.; RESSTEL, LEONARDO B. M.; JOCA, SAMIA R. L.. Dorsal and Ventral Hippocampus Modulate Autonomic Responses but Not Behavioral Consequences Associated to Acute Restraint Stress in Rats. PLoS One, v. 8, n. 10, OCT 17 2013. Web of Science Citations: 13. (12/09300-4, 11/17281-7)
WERNER, CRAIG T.; MITRA, SWARUP; AUERBACH, BENJAMIN D.; WANG, ZI-JUN; MARTIN, JENNIFER A.; STEWART, ANDREW F.; GOBIRA, PEDRO H.; IIDA, MADOKA; AN, CHUNNA; COBB, MORIAH M.; et al. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, n. 42, p. 26460-26469, OCT 20 2020. Web of Science Citations: 0. (17/19284-0)
SALES, AMANDA J.; FOGACA, MANOELA V.; SARTIM, ARIANDRA G.; PEREIRA, VITOR S.; WEGENER, GREGERS; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, v. 56, n. 2, p. 1070-1081, FEB 2019. Web of Science Citations: 17. (12/17626-7, 15/01955-0)
PEREIRA, VITOR S.; CASAROTTO, PLINIO C.; HIROAKI-SATO, VINICIUS A.; SARTIM, ARIANDRA G.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide. European Neuropsychopharmacology, v. 23, n. 12, p. 1769-1778, DEC 2013. Web of Science Citations: 25. (07/03685-3, 11/17281-7)
SALES, AMANDA J.; JOCA, SAMIA R. L.. Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus. Behavioural Brain Research, v. 343, p. 8-15, MAY 2 2018. Web of Science Citations: 2. (11/17281-7)
LISBOA, SABRINA F.; GOMES, FELIPE V.; SILVA, ANDREIA L.; ULIANA, DANIELA L.; CAMARGO, LAURA H. A.; GUIMARAES, FRANCISCO S.; CUNHA, FERNANDO Q.; JOCA, SAMIA R. L.; RESSTEL, LEONARDO B. M.. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 18, n. 8, JUN 2015. Web of Science Citations: 16. (11/22523-0)
MONTEZUMA, KARINA; BIOJONE, CAROLINE; LISBOA, SABRINA F.; CUNHA, FERNANDO Q.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence. Neuropharmacology, v. 62, n. 1, SI, p. 485-491, JAN 2012. Web of Science Citations: 44. (07/03685-3)
SALES, AMANDA J.; BIOJONE, CAROLINE; TERCETI, MATEUS S.; GUIMARAES, FRANCISCO S.; GOMES, MARCUS V. M.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. British Journal of Pharmacology, v. 164, n. 6, p. 1711-1721, NOV 2011. Web of Science Citations: 70. (07/03685-3)
JOCA‚ S.R.L.; ZANELATI‚ T.; GUIMARÃES‚ F.S.. Post-stress facilitation of serotonergic‚ but not noradrenergic‚ neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain Research, v. 1087, n. 1, p. 67-74, 2006. (02/13197-2)
MITRA, SWARUP; GOBIRA, PEDRO H.; WERNER, CRAIG T.; MARTIN, JENNIFER A.; IIDA, MADOKA; THOMAS, SHRUTHI A.; ERIAS, KYRA; MIRACLE, SOPHIA; LAFARGUE, CHARLES; AN, CHUNNA; et al. A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue-induced cocaine craving following prolonged abstinence. ADDICTION BIOLOGY, JAN 2021. Web of Science Citations: 0. (17/19284-0)
STANQUINI, LAURA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A.; JOCA, SAMIA R. L.; SCOPINHO, AMERICA A.. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology Biochemistry and Behavior, v. 136, p. 31-38, SEP 2015. Web of Science Citations: 3. (13/06569-5)
SARTIM, ARIANDRA G.; SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test. JOURNAL OF PSYCHOPHARMACOLOGY, v. 32, n. 8, p. 922-931, AUG 2018. Web of Science Citations: 3. (15/01955-0)
SARTIM, A. G.; SARTIM, M. A.; CUMMINGS, R. D.; DIAS-BARUFFI, M.; JOCA, S. R.. Impaired emotional response to stress in mice lacking galectin-1 or galectin-3. Physiology & Behavior, v. 220, JUN 1 2020. Web of Science Citations: 0. (13/00279-5)
SILOTE, GABRIELA P.; DE OLIVEIRA, SABRINA F. S.; RIBEIRO, DEIDIANE E.; MACHADO, MAYARA S.; ANDREATINI, ROBERTO; JOCA, SAMIA R. L.; BEIJAMINI, VANESSA. Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 100, JUN 8 2020. Web of Science Citations: 0. (17/26815-1, 18/12119-6)
MACIEL, IZAQUE DE SOUSA; SALES, AMANDA J.; CASAROTTO, PLINIO C.; CASTREN, EERO; BIOJONE, CAROLINE; JOCA, SAMIA R. L.. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. European Journal of Neuroscience, DEC 2020. Web of Science Citations: 0. (15/25067-6, 15/06271-1, 17/24304-0)
SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim. Behavioural Brain Research, v. 388, JUN 18 2020. Web of Science Citations: 0. (12/17626-7, 11/17281-7)
CANTELMO, REBECA ARAUJO; DOS SANTOS, NEIFE APARECIDA G.; DOS SANTOS, ANTONIO CARDOZO; JOCA, SAMIA REGIANE LOURENCO. Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+. Journal of Pharmacy and Pharmacology, v. 72, n. 10, JUN 2020. Web of Science Citations: 0. (15/05530-3)
SALES, AMANDA JULIANA; LOURENCO JOCA, SAMIA REGIANE. Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels. ACTA NEUROPSYCHIATRICA, v. 28, n. 1, p. 11-22, FEB 2016. Web of Science Citations: 16. (12/17626-7, 11/17281-7)
SARTIM, A. G.; MOREIRA, F. A.; JOCA, S. R. L.. INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR. Neuroscience, v. 340, p. 126-134, JAN 6 2017. Web of Science Citations: 9. (12/17626-7, 13/00279-5)
WERNER, CRAIG T.; MITRA, SWARUP; AUERBACH, BENJAMIN D.; WANG, ZI-JUN; MARTIN, JENNIFER A.; STEWART, ANDREW F.; GOBIRA, PEDRO H.; IIDA, MADOKA; AN, CHUNNA; COBB, MORIAH M.; et al. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 117, n. 42, p. 26460-26469, OCT 20 2020. Web of Science Citations: 0. (17/19284-0)
SALES, AMANDA J.; FOGACA, MANOELA V.; SARTIM, ARIANDRA G.; PEREIRA, VITOR S.; WEGENER, GREGERS; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, v. 56, n. 2, p. 1070-1081, FEB 2019. Web of Science Citations: 17. (12/17626-7, 15/01955-0)
SALES, AMANDA J.; JOCA, SAMIA R. L.. Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus. Behavioural Brain Research, v. 343, p. 8-15, MAY 2 2018. Web of Science Citations: 2. (11/17281-7)
PEREIRA, VITOR S.; CASAROTTO, PLINIO C.; HIROAKI-SATO, VINICIUS A.; SARTIM, ARIANDRA G.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide. European Neuropsychopharmacology, v. 23, n. 12, p. 1769-1778, DEC 2013. Web of Science Citations: 25. (07/03685-3, 11/17281-7)
LISBOA, SABRINA F.; GOMES, FELIPE V.; SILVA, ANDREIA L.; ULIANA, DANIELA L.; CAMARGO, LAURA H. A.; GUIMARAES, FRANCISCO S.; CUNHA, FERNANDO Q.; JOCA, SAMIA R. L.; RESSTEL, LEONARDO B. M.. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 18, n. 8, JUN 2015. Web of Science Citations: 16. (11/22523-0)
MITRA, SWARUP; GOBIRA, PEDRO H.; WERNER, CRAIG T.; MARTIN, JENNIFER A.; IIDA, MADOKA; THOMAS, SHRUTHI A.; ERIAS, KYRA; MIRACLE, SOPHIA; LAFARGUE, CHARLES; AN, CHUNNA; et al. A role for the endocannabinoid enzymes monoacylglycerol and diacylglycerol lipases in cue-induced cocaine craving following prolonged abstinence. ADDICTION BIOLOGY, JAN 2021. Web of Science Citations: 0. (17/19284-0)
SALES, AMANDA J.; MACIEL, IZAQUE S.; SUAVINHA, ANGELICA C. D. R.; JOCA, SAMIA R. L.. Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects. Molecular Neurobiology, v. 58, n. 2, p. 777-794, FEB 2021. Web of Science Citations: 1. (15/01955-0, 11/17281-7, 12/17626-7)
JOCA‚ S.R.L.; ZANELATI‚ T.; GUIMARÃES‚ F.S.. Post-stress facilitation of serotonergic‚ but not noradrenergic‚ neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain Research, v. 1087, n. 1, p. 67-74, 2006. (02/13197-2)
SCOPINHO, AMERICA A.; LISBOA, SABRINA F. S.; GUIMARAES, FRANCISCO S.; CORREA, FERNANDO M. A.; RESSTEL, LEONARDO B. M.; JOCA, SAMIA R. L.. Dorsal and Ventral Hippocampus Modulate Autonomic Responses but Not Behavioral Consequences Associated to Acute Restraint Stress in Rats. PLoS One, v. 8, n. 10, OCT 17 2013. Web of Science Citations: 13. (12/09300-4, 11/17281-7)
MONTEZUMA, KARINA; BIOJONE, CAROLINE; LISBOA, SABRINA F.; CUNHA, FERNANDO Q.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence. Neuropharmacology, v. 62, n. 1, SI, p. 485-491, JAN 2012. Web of Science Citations: 44. (07/03685-3)
SALES, AMANDA J.; BIOJONE, CAROLINE; TERCETI, MATEUS S.; GUIMARAES, FRANCISCO S.; GOMES, MARCUS V. M.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. British Journal of Pharmacology, v. 164, n. 6, p. 1711-1721, NOV 2011. Web of Science Citations: 70. (07/03685-3)
(References retrieved automatically from State of São Paulo Research Institutions)
MONTEZUMA, Karina. Efeito de antagonistas do receptor NMDA sobre a metilação do DNA. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (14/02666-9)
NAGAI, Michelly Martins. Participação do sistema noradrenérgico do núcleo leito da estria terminal na mediação das consequências comportamentais do estresse. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/12023-7)
SARTIM, Ariandra Guerini. Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/00279-5)
SARTIM, Ariandra Guerini. Efeitos da administração de canabidiol no CPFmv de ratos submetidos ao teste do nado forçado. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (11/01849-4)
CANTELMO, Rebeca Araujo. Efeito de inibidores da metilação de DNA sobre a neurotoxicidade induzida por iodeto de 1-metil-4-fenilpiridínio (MPP+) em modelo de células neuroniais. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (15/05530-3)