Sâmia Regiane Lourenço Joca
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Farmácia Bioquímia from Universidade Federal do Paraná (1999) and doctorate at Pharmacology from Universidade de São Paulo (2004). Has experience in Pharmacology, focusing on Psychopharmacology, acting on the following subjects: antidepressant, cannabinoids, nitric oxide, stress and neuroplasticity. (Source: Lattes Curriculum)
- New perspectives in the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders, AP.TEM
Abstract
The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive,...
- Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders, AP.TEM
Abstract
In the last 15 years our group has contributed to a better understanding of the role of nitric oxide (NO) and endocannabinoids (eCBs) in physiological and pathophysiological processes of the central nervous system. We showed that manipulations of these atypical neurotransmitters are able to change behavioral and autonomic responses of laboratory animals submitted to animal models of anx...
- Molecular mechanisms involved in the behavioral phenotype of iNOS Knockout animals exposed to a test predictive of antidepressant-like effects, AP.R
Abstract
Several studies indicate that inhibition of nitric oxide (NO) induces antidepressant-like effects in animal models. Recent evidence from our research group suggest that the inducible isoform of NO synthase (iNOS) plays an important role in regulating the production of NO during exposure to stress, since its pharmacological inhibition or its gene expression (knockout, KO) induces antidep...
- Involvement of epigenetic mechanisms induced by DNA methylation on stress-induced behavioral consequences and on the expression of genes involved in the neurobiology of depression, AP.R
Abstract
Recent studies indicate that epigenetic mechanisms migh be involved in the neurobiology of depression. For example, DNA methylation, which is associated with transcriptional repression, is increased by exposure to stress. Besides, high levels of methylation in specific gene loci were found in the brains of suicide victims. In addition, preliminary results of our research group showed th...
(Only some records are available in English at this moment)
- Evaluation of P2X7-induced inflammasome activation and microglia M1/M2 polarization in an animal model of treatment-resistant depression, BP.PD
Abstract
Around 30-60% of patients treated with routine antidepressant medications fail to achieve effectively remission of depressive symptoms leading to treatment resistant depression (TRD). In this condition, augmentation therapy such as adding of a mood stabiliser (such as lamotrigine or lithium) or an antipsychotic (such as olanzapine, quetiapine or risperidone) to an existing antidepressan...
- Participation of P2X7-NLRP3 pathway in the modulation of behavioral, neurochemical and neuroplastic changes induced by stress, BP.DR
Abstract
Depression is a complex affective disorder whose most accepted pharmacological cause is monoamine deficiency. In addition, current neurobiological theories have investigated the involvement of glutamate and GABA in order to find new drugs and better understand the neural bases and the cellular and molecular mechanisms involved, since a considerable number of patients do not respond to c...
- Sensitization to cocaine induced by previous exposure to cannabinoids: involvement of epigenetic mechanisms induced by DNA methylation, BP.PD
Abstract
Several evidence suggests that repeated exposure to cocaine promotes structural and electrophysiological modifications in encephalic mesolimbic pathway, that result in behavioral changes related to abuse. These neural adaptations may be due to modulation of gene expression, which are critically regulated by epigenetic mechanisms. Recently, the influence of these regulatory mechanisms in...
- Investigation of the involvement of the BDNF-TrkB pathway in the mechanism of action of the rapid and sustained antidepressant-like effect induced by canabidiol, BP.DR
Abstract
Depression is a debilitating psychiatric disorder. Antidepressants have limitations on their use, such as the delay of four to six weeks for onset of therapeutic action and inefficiency in 30-45% of patients.Among the substances that present a better therapeutic profile are cannabidiol (CBD), which showed a rapid and sustained antidepressant effect in animal models. The mechanisms respo...
- Involvement of the endocannabinoid system in alprazola-induced antidepressant-like responses in mice, BP.IC
Abstract
Depression is a recurrent, long-lasting and disabling mental disorder that, despite efforts to comprehend its neurobiology, still lacks sufficiently effective treatments that quickly induces effect. Among the various neurobiological changes inherent to this disorder, a decrease in gabaergic neurotransmission seems to be involved in the etiology of depression. Indeed, treatment with alpr...
- Effect of inhibitors of DNMTs and antidepressants on DNA methylation in candidate genes involved in the neurobiology of depression, BP.DR
Abstract
Introduction: Epigenetic mechanisms, such as DNA methylation (is regulated by DNMTs), are thought to play an important role in the neurobiology of depression. In this sense, we demonstrated that inhibitors DNA methylation have antidepressant-like effect in animals submitted to forced swimming test and tail suspension. Objectives: Whereas DNMTs inhibitors have different mechanism of acti...
(Only some records are available in English at this moment)
- Investigation of the molecular mechanisms involved in the rapid and sustained antidepressant-like effects induced by cannabidiol, BE.EP.DR
Abstract
Depression is a debilitating and disabling psychiatric disorder. Dysfunction on pre-frontal cortex (PFC) have been related to depression. Ketamine is an important drug that produces rapid and sustained antidepressant effects, which seems to involve activation of the BDNF-TrkB-mTOR pathway, with subsequent activation of MEK and PI3K, leading to increased synaptogenesis. We have recently ...
- Involvement of histone acetylation in modulating vulnerability to the cocaine-effects induced by exposure to cannabinoids during adolescence, BE.EP.PD
Abstract
Repeated exposure to cocaine promotes structural and electrophysiological changes in the mesolimbic encephalic pathway, which regulates behaviors related to abuse. These complex adaptations in the brain are mediated by dynamic patterns of gene expression that are translated into enduring changes critically regulated by epigenetics mechanisms, including histone acetylation. Indeed, recen...
- Assessment of the effect of the nitric oxide synthase inhibitors on DNA methylation and the activity and expression of DNA methyltransferases in rat brain cell culture, BE.EP.DR
Abstract
The majority of major depression (MD) is preceded by stressful events. The stress leads to an increase in glutamate release, synthesis and release of nitric oxide (NO) as well as epigenetic changes induced by increased DNA methylation in the promoter regions of genes involved in the pathophysiology of MD. It has been demonstrated that oxidative stress and NO can modulate mediators respo...
- Involvement of BDNF-TrkB signaling in the antidepressant-like effects of the nitric oxide in the frontal cortex, BE.EP.PD
Abstract
There is evidence indicating that L-arginine (a nitric oxide synthase substrate) administration induces biphasic effects in the forced swimming test. It suggests that nitric oxide could induce both antidepressant- and depressive-like effects. Moreover, our group has demonstrated that transgenic mice that present increased nitric oxide production in the frontal cortex present antidepress...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 18 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 33 / 32 | All research grants and scholarships |
| Associated processes | |
- Vitor Silva Pereira
- Ariandra Guerini Sartim
- Caroline Biojone
- Amanda Juliana Sales
- Izaque de Sousa Maciel
- Pedro Henrique Gobira Nunes
- Gabriela Pandini Silote
- Francisco Silveira Guimaraes
- Michelly Martins Nagai
- Vinicius Antonio Hiroaki Sato
- Angélica Caroline Dutra Romano
- Cassiano Ricardo Alves Faria Diniz
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 251 |
| Cit./Article | 13.9 |
| Data from Web of Science | |
MONTEZUMA, KARINA; BIOJONE, CAROLINE; LISBOA, SABRINA F.; CUNHA, FERNANDO Q.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Inhibition of iNOS induces antidepressant-like effects in mice: Pharmacological and genetic evidence. Neuropharmacology, v. 62, n. 1, SI, p. 485-491, JAN 2012. Web of Science Citations: 47. (07/03685-3)
SALES, AMANDA J.; BIOJONE, CAROLINE; TERCETI, MATEUS S.; GUIMARAES, FRANCISCO S.; GOMES, MARCUS V. M.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. British Journal of Pharmacology, v. 164, n. 6, p. 1711-1721, NOV 2011. Web of Science Citations: 71. (07/03685-3)
SILVA, MICHELLE; AGUIAR, DANIELE C.; DINIZ, CASSIANO R. A.; GUIMARAES, FRANCISCO SILVEIRA; JOCA, SAMIA R. L.. Neuronal NOS Inhibitor and Conventional Antidepressant Drugs Attenuate Stress-induced Fos Expression in Overlapping Brain Regions. Cellular and Molecular Neurobiology, v. 32, n. 3, p. 443-453, APR 2012. Web of Science Citations: 25. (07/03685-3)
SALES, AMANDA J.; CRESTANI, CARLOS C.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 86, p. 255-261, AUG 30 2018. Web of Science Citations: 6. (15/01955-0)
SALES, AMANDA JULIANA; LOURENCO JOCA, SAMIA REGIANE. Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels. ACTA NEUROPSYCHIATRICA, v. 28, n. 1, p. 11-22, FEB 2016. Web of Science Citations: 16. (12/17626-7, 11/17281-7)
DINIZ, CASSIANO R. A. F.; BIOJONE, CAROLINE; JOCA, SARNIA R. L.; RANTAMAKI, TOMI; CASTREN, EERO; GUIMARAES, FRANCISCO S.; CASAROTTO, PLINIO C.. Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ, v. 7, FEB 21 2019. Web of Science Citations: 0. (13/02549-0, 18/04250-5, 11/02746-4, 13/01029-2)
SALES, AMANDA J.; FOGACA, MANOELA V.; SARTIM, ARIANDRA G.; PEREIRA, VITOR S.; WEGENER, GREGERS; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular Neurobiology, v. 56, n. 2, p. 1070-1081, FEB 2019. Web of Science Citations: 11. (12/17626-7, 15/01955-0)
SALES, AMANDA J.; JOCA, SAMIA R. L.. Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus. Behavioural Brain Research, v. 343, p. 8-15, MAY 2 2018. Web of Science Citations: 2. (11/17281-7)
CASAROTTO, PLINIO C.; BIOJONE, CAROLINE; MONTEZUMA, KARINA; CUNHA, FERNANDO Q.; JOCA, SAMIA R. L.; CASTREN, EERO; GUIMARAES, FRANCISCO S.. Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania. PeerJ, v. 6, APR 17 2018. Web of Science Citations: 1. (11/02746-4)
GODOY, LIVEA DORNELA; UMEOKA, EDUARDO H. L.; RIBEIRO, DEIDIANE ELISA; SANTOS, VICTOR RODRIGUES; ANTUNES-RODRIGUES, JOSE; LOURENCO JOCA, SAMIA REGIANE; GARCIA-CAIRASCO, NORBERTO. Multimodal early-life stress induces biological changes associated to psychopathologies. Hormones and Behavior, v. 100, p. 69-80, APR 2018. Web of Science Citations: 3. (14/17959-1, 15/18773-1, 17/11339-0, 13/01737-7)
SCOPINHO, AMERICA A.; LISBOA, SABRINA F. S.; GUIMARAES, FRANCISCO S.; CORREA, FERNANDO M. A.; RESSTEL, LEONARDO B. M.; JOCA, SAMIA R. L.. Dorsal and Ventral Hippocampus Modulate Autonomic Responses but Not Behavioral Consequences Associated to Acute Restraint Stress in Rats. PLoS One, v. 8, n. 10, OCT 17 2013. Web of Science Citations: 13. (11/17281-7, 12/09300-4)
SARTIM, ARIANDRA G.; SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test. JOURNAL OF PSYCHOPHARMACOLOGY, v. 32, n. 8, p. 922-931, AUG 2018. Web of Science Citations: 1. (15/01955-0)
PEREIRA, VITOR SILVA; ELFVING, BETINA; JOCA, SAMIA R. L.; WEGENER, GREGERS. Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. European Journal of Pharmacology, v. 815, p. 304-311, NOV 15 2017. Web of Science Citations: 3. (13/00916-5)
SARTIM, A. G.; MOREIRA, F. A.; JOCA, S. R. L.. INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR. Neuroscience, v. 340, p. 126-134, JAN 6 2017. Web of Science Citations: 7. (12/17626-7, 13/00279-5)
LISBOA, SABRINA F.; GOMES, FELIPE V.; SILVA, ANDREIA L.; ULIANA, DANIELA L.; CAMARGO, LAURA H. A.; GUIMARAES, FRANCISCO S.; CUNHA, FERNANDO Q.; JOCA, SAMIA R. L.; RESSTEL, LEONARDO B. M.. Increased Contextual Fear Conditioning in iNOS Knockout Mice: Additional Evidence for the Involvement of Nitric Oxide in Stress-Related Disorders and Contribution of the Endocannabinoid System. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v. 18, n. 8, JUN 2015. Web of Science Citations: 16. (11/22523-0)
STANQUINI, LAURA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A.; JOCA, SAMIA R. L.; SCOPINHO, AMERICA A.. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology Biochemistry and Behavior, v. 136, p. 31-38, SEP 2015. Web of Science Citations: 3. (13/06569-5)
PEREIRA, VITOR S.; CASAROTTO, PLINIO C.; HIROAKI-SATO, VINICIUS A.; SARTIM, ARIANDRA G.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide. European Neuropsychopharmacology, v. 23, n. 12, p. 1769-1778, DEC 2013. Web of Science Citations: 26. (11/17281-7, 07/03685-3)
JOCA‚ S.R.L.; ZANELATI‚ T.; GUIMARÃES‚ F.S.. Post-stress facilitation of serotonergic‚ but not noradrenergic‚ neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain Research, v. 1087, n. 1, p. 67-74, 2006. (02/13197-2)
SARTIM, ARIANDRA G.; BRITO, BIANCA M.; GOBIRA, PEDRO H.; JOCA, SAMIA R. L.. Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test. Behavioural Pharmacology, v. 30, n. 1, p. 59-66, FEB 2019. Web of Science Citations: 0. (12/17626-7)