CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Farmácia Bioquímia from Universidade Federal do Paraná (1999) and doctorate at Pharmacology from Universidade de São Paulo (2004). Has experience in Pharmacology, focusing on Psychopharmacology, acting on the following subjects: antidepressant, cannabinoids, nitric oxide, stress and neuroplasticity. (Source: Lattes Curriculum)
The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, p…
In the last 15 years our group has contributed to a better understanding of the role of nitric oxide (NO) and endocannabinoids (eCBs) in physiological and pathophysiological processes of the central nervous system. We showed that manipulations of these atypical neurotransmitters are able to change behavioral and autonomic responses of laboratory animals submitted to animal models of anxie…
Several studies indicate that inhibition of nitric oxide (NO) induces antidepressant-like effects in animal models. Recent evidence from our research group suggest that the inducible isoform of NO synthase (iNOS) plays an important role in regulating the production of NO during exposure to stress, since its pharmacological inhibition or its gene expression (knockout, KO) induces antidepre…
Recent studies indicate that epigenetic mechanisms migh be involved in the neurobiology of depression. For example, DNA methylation, which is associated with transcriptional repression, is increased by exposure to stress. Besides, high levels of methylation in specific gene loci were found in the brains of suicide victims. In addition, preliminary results of our research group showed that…
(Only some records are available in English at this moment)
Depression is a debilitating psychiatric disorder. Antidepressants have limitations on their use, such as the delay of four to six weeks for onset of therapeutic action and inefficiency in 30-45% of patients.Among the substances that present a better therapeutic profile are cannabidiol (CBD), which showed a rapid and sustained antidepressant effect in animal models. The mechanisms respons…
Depression is a recurrent, long-lasting and disabling mental disorder that, despite efforts to comprehend its neurobiology, still lacks sufficiently effective treatments that quickly induces effect. Among the various neurobiological changes inherent to this disorder, a decrease in gabaergic neurotransmission seems to be involved in the etiology of depression. Indeed, treatment with alpraz…
Several evidence suggests that repeated exposure to cocaine promotes structural and electrophysiological modifications in encephalic mesolimbic pathway, that result in behavioral changes related to abuse. These neural adaptations may be due to modulation of gene expression, which are critically regulated by epigenetic mechanisms. Recently, the influence of these regulatory mechanisms in m…
(Only some records are available in English at this moment)
Depression is a debilitating and disabling psychiatric disorder. Dysfunction on pre-frontal cortex (PFC) have been related to depression. Ketamine is an important drug that produces rapid and sustained antidepressant effects, which seems to involve activation of the BDNF-TrkB-mTOR pathway, with subsequent activation of MEK and PI3K, leading to increased synaptogenesis. We have recently sh…
Repeated exposure to cocaine promotes structural and electrophysiological changes in the mesolimbic encephalic pathway, which regulates behaviors related to abuse. These complex adaptations in the brain are mediated by dynamic patterns of gene expression that are translated into enduring changes critically regulated by epigenetics mechanisms, including histone acetylation. Indeed, recent …
The majority of major depression (MD) is preceded by stressful events. The stress leads to an increase in glutamate release, synthesis and release of nitric oxide (NO) as well as epigenetic changes induced by increased DNA methylation in the promoter regions of genes involved in the pathophysiology of MD. It has been demonstrated that oxidative stress and NO can modulate mediators respons…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 19 / 18 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 31 / 30 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 22 |
| Citations | 107 |
| Cit./Article | 4.9 |
| Data from Web of Science | |
MACIEL, IZAQUE DE SOUSA; SALES, AMANDA J.; CASAROTTO, PLINIO C.; CASTREN, EERO; BIOJONE, CAROLINE; JOCA, SAMIA R. L.. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. European Journal of Neuroscience, DEC 2020. Web of Science Citations: 0. (15/25067-6, 15/06271-1, 17/24304-0)
SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim. Behavioural Brain Research, v. 388, JUN 18 2020. Web of Science Citations: 0. (12/17626-7, 11/17281-7)
DINIZ, CASSIANO R. A. F.; BIOJONE, CAROLINE; JOCA, SARNIA R. L.; RANTAMAKI, TOMI; CASTREN, EERO; GUIMARAES, FRANCISCO S.; CASAROTTO, PLINIO C.. Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ, v. 7, FEB 21 2019. Web of Science Citations: 0. (13/02549-0, 18/04250-5, 11/02746-4, 13/01029-2)
GODOY, LIVEA DORNELA; UMEOKA, EDUARDO H. L.; RIBEIRO, DEIDIANE ELISA; SANTOS, VICTOR RODRIGUES; ANTUNES-RODRIGUES, JOSE; LOURENCO JOCA, SAMIA REGIANE; GARCIA-CAIRASCO, NORBERTO. Multimodal early-life stress induces biological changes associated to psychopathologies. Hormones and Behavior, v. 100, p. 69-80, APR 2018. Web of Science Citations: 3. (14/17959-1, 13/01737-7, 15/18773-1, 17/11339-0)
RIBEIRO, DEIDIANE E.; MUELLER, HEIDI K.; ELFVING, BETINA; ESKELUND, AMANDA; JOCA, SAMIA R. L.; WEGENER, GREGERS. Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 11, p. 1436-1446, NOV 2019. Web of Science Citations: 1. (13/01737-7)
RIBEIRO, DEIDIANE ELISA; CASAROTTO, PLINIO C.; STAQUINI, LAURA; PINTO E SILVA, MARIA AUGUSTA; BIOJONE, CAROLINE; WEGENER, GREGERS; JOCA, SAMIA. Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. PeerJ, v. 7, OCT 21 2019. Web of Science Citations: 0. (13/01737-7)
WERNER, C. T.; MITRA, S.; MARTIN, J. A.; STEWART, A. F.; LEPACK, A. E.; RAMAKRISHNAN, A.; GOBIRA, P. H.; WANG, Z. -J.; NEVE, R. L.; GANCARZ, A. M.; et al. Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving. SCIENCE ADVANCES, v. 5, n. 10, OCT 2019. Web of Science Citations: 0. (17/19284-0)
SILOTE, GABRIELA P.; DE OLIVEIRA, SABRINA F. S.; RIBEIRO, DEIDIANE E.; MACHADO, MAYARA S.; ANDREATINI, ROBERTO; JOCA, SAMIA R. L.; BEIJAMINI, VANESSA. Ketamine effects on anxiety and fear-related behaviors: Current literature evidence and new findings. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 100, JUN 8 2020. Web of Science Citations: 0. (17/26815-1, 18/12119-6)
SALES, AMANDA J.; CRESTANI, CARLOS C.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 86, p. 255-261, AUG 30 2018. Web of Science Citations: 11. (15/01955-0)
SARTIM, A. G.; SARTIM, M. A.; CUMMINGS, R. D.; DIAS-BARUFFI, M.; JOCA, S. R.. Impaired emotional response to stress in mice lacking galectin-1 or galectin-3. Physiology & Behavior, v. 220, JUN 1 2020. Web of Science Citations: 0. (13/00279-5)
SALES, AMANDA J.; CRESTANI, CARLOS C.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 86, p. 255-261, AUG 30 2018. Web of Science Citations: 11. (15/01955-0)
RIBEIRO, DEIDIANE E.; MUELLER, HEIDI K.; ELFVING, BETINA; ESKELUND, AMANDA; JOCA, SAMIA R. L.; WEGENER, GREGERS. Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 11, p. 1436-1446, NOV 2019. Web of Science Citations: 1. (13/01737-7)
RIBEIRO, DEIDIANE ELISA; CASAROTTO, PLINIO C.; STAQUINI, LAURA; PINTO E SILVA, MARIA AUGUSTA; BIOJONE, CAROLINE; WEGENER, GREGERS; JOCA, SAMIA. Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model. PeerJ, v. 7, OCT 21 2019. Web of Science Citations: 0. (13/01737-7)
WERNER, C. T.; MITRA, S.; MARTIN, J. A.; STEWART, A. F.; LEPACK, A. E.; RAMAKRISHNAN, A.; GOBIRA, P. H.; WANG, Z. -J.; NEVE, R. L.; GANCARZ, A. M.; et al. Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving. SCIENCE ADVANCES, v. 5, n. 10, OCT 2019. Web of Science Citations: 0. (17/19284-0)
GODOY, LIVEA DORNELA; UMEOKA, EDUARDO H. L.; RIBEIRO, DEIDIANE ELISA; SANTOS, VICTOR RODRIGUES; ANTUNES-RODRIGUES, JOSE; LOURENCO JOCA, SAMIA REGIANE; GARCIA-CAIRASCO, NORBERTO. Multimodal early-life stress induces biological changes associated to psychopathologies. Hormones and Behavior, v. 100, p. 69-80, APR 2018. Web of Science Citations: 3. (14/17959-1, 13/01737-7, 15/18773-1, 17/11339-0)
STANQUINI, LAURA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A.; JOCA, SAMIA R. L.; SCOPINHO, AMERICA A.. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology Biochemistry and Behavior, v. 136, p. 31-38, SEP 2015. Web of Science Citations: 3. (13/06569-5)
SALES, AMANDA JULIANA; LOURENCO JOCA, SAMIA REGIANE. Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels. ACTA NEUROPSYCHIATRICA, v. 28, n. 1, p. 11-22, FEB 2016. Web of Science Citations: 16. (12/17626-7, 11/17281-7)
SARTIM, A. G.; MOREIRA, F. A.; JOCA, S. R. L.. INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR. Neuroscience, v. 340, p. 126-134, JAN 6 2017. Web of Science Citations: 9. (13/00279-5, 12/17626-7)
PEREIRA, VITOR SILVA; ELFVING, BETINA; JOCA, SAMIA R. L.; WEGENER, GREGERS. Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. European Journal of Pharmacology, v. 815, p. 304-311, NOV 15 2017. Web of Science Citations: 4. (13/00916-5)
SARTIM, ARIANDRA G.; SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test. JOURNAL OF PSYCHOPHARMACOLOGY, v. 32, n. 8, p. 922-931, AUG 2018. Web of Science Citations: 3. (15/01955-0)
SARTIM, ARIANDRA G.; SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.. Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test. JOURNAL OF PSYCHOPHARMACOLOGY, v. 32, n. 8, p. 922-931, AUG 2018. Web of Science Citations: 3. (15/01955-0)
SARTIM, A. G.; MOREIRA, F. A.; JOCA, S. R. L.. INVOLVEMENT OF CB1 AND TRPV1 RECEPTORS LOCATED IN THE VENTRAL MEDIAL PREFRONTAL CORTEX IN THE MODULATION OF STRESS COPING BEHAVIOR. Neuroscience, v. 340, p. 126-134, JAN 6 2017. Web of Science Citations: 9. (13/00279-5, 12/17626-7)
CANTELMO, REBECA ARAUJO; DOS SANTOS, NEIFE APARECIDA G.; DOS SANTOS, ANTONIO CARDOZO; JOCA, SAMIA REGIANE LOURENCO. Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+. Journal of Pharmacy and Pharmacology, v. 72, n. 10, JUN 2020. Web of Science Citations: 0. (15/05530-3)
(References retrieved automatically from State of São Paulo Research Institutions)
SARTIM, Ariandra Guerini. Efeitos da administração de canabidiol no CPFmv de ratos submetidos ao teste do nado forçado. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (11/01849-4)
MONTEZUMA, Karina. Efeito de antagonistas do receptor NMDA sobre a metilação do DNA. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (14/02666-9)
NAGAI, Michelly Martins. Participação do sistema noradrenérgico do núcleo leito da estria terminal na mediação das consequências comportamentais do estresse. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/12023-7)
SARTIM, Ariandra Guerini. Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/00279-5)
CANTELMO, Rebeca Araujo. Efeito de inibidores da metilação de DNA sobre a neurotoxicidade induzida por iodeto de 1-metil-4-fenilpiridínio (MPP+) em modelo de células neuroniais. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (15/05530-3)