CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Prof. Dr. Dulce Elena Casarini, CNPq Researcher 1B, holds a degree in Biology from the University of the Sacred Heart (1973). Defended Master (1982) and PhD (1988) in Biological Sciences (Molecular Biology) and Free Teaching in Nephrology (2003) at the Federal University of São Paulo (UNIFESP). Received the title of Fellow American Heart Association (FAHA). She is currently Associate Professor and Professor of the Nephrology and Biologist Discipline of UNIFESP. He teaches nephrology classes for the 4th medical year of Escola Paulista de Medicina, EPM. She is Coordinator of the Graduate Program in Translational Medicine of the Department of Medicine, EPM, UNIFESP. Has research in Medicine, focusing on Clinical and Basic Nephrology/Cardiology in renal and cardiovascular diseases, acting on the following subjects: renin angiotensin, kallikrein kinins and catecholamines systems in hypertension, diabetes, obesity and transplantation; and in enzymology, proteomics and metabolomics. She is a biologist graduated in 1973 at the Sacred Heart University, Brazil. In 1982, he obtained a master's degree and, in 1988, a doctorate, both in Molecular Biology, EPM, UNIFESP, Brazil. In 1979 she joined UNIFESP as a scientific researcher and founded the Kidney and Hormones Research Laboratory, Department of Medicine, Nephrology Discipline, EPM. In Paris, he did two postdoctoral degrees: one at the Laboratoire de Physiologie Nerveuse, Gif sur Yvette (1989-1990), and the second at the Laboratory of Physiology and Vascular and Renal Pathology, Unité 367, INSERM (1993-1994). Discovered an important biological marker for hypertension, the angiotensin I-converting enzyme n-domain isoform (nECA), patented it in Brazil in 2002, (nECA / genetic marker of hypertension. Quantification method), and in 2008 obtained patent worldwide. Demonstrated dedication and commitment to excellence in the training of 26 doctors, 27 masters, 20 postdocs and 22 scientific initiations. During his career he published over 164 manuscripts in clinical and basic research, several book chapters, and edited two abroad. She is invited as a speaker or session chairman at national and international meetings and medical schools annually. Received many awards being the last in May 2019 from the American Society of Physiology featuring work on Clinical Hypertension / biological marker of hypertension. He is a member of the Brazilian Societies of Biochemistry and Hypertension, and the Inter-American Society of Hypertension, International Society of Proteolysis, American Heart Society and American Society of Physiology. Dr. Casarini was treasurer of the Brazilian Society of Hypertension 2017-August 2019, and is a member of the scientific council until 2022. She is on the scientific committee of the Gordon Angiotensin Conference, Gordon Foundation, USA, and was elected for the 2018 term. -2022. She was nominated by the American Heart Association's (AHA) HTN Council Nominating Committee (USA) to serve the AHA International Committee pending final nomination. It is on the editorial board of PlosOne and the Open Journal of Transplantation. She is a reviewer for journals in cardiovascular, nephrology, biochemistry and physiology. She is an advisor for the judgment of clinical and basic projects of different foundations in Brazil: Fapesp, Fapemig, Auraucária Foundation, Cearence Foundation, Federal District Research Support Foundation, Fapesb, Fapeam, among others in the country. She was an advisor for international bodies such as: Cytec/CNPq, a financial aid to scientific and technological cooperation among the member countries of South America, and others; Ministry of Science, Technology and Productive Innovation Funding for Scientific and Technological Research of Argentina. Contest stand for Full Professor, candidate Prof. Dr Khalid Elased for Full Professor, Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OHIO. (Source: Lattes Curriculum)
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The proposal of this project is to acquire a small-medium equipment a SCIEX TRIPLE QUAD 6500+ SYSTEM equipment with high sensitivity, since we had a Sciex 3200 deactivated, so that we can maintain, expand and strengthen existing partnerships with national and international partner institutions, which increase data quality generated and encourages the training of human resources to work i…
Cardiovascular and renal diseases are among the main "non-contagious pandemics" because they are responsible for exponential increase in morbidity and early mortality around the world. Common risk factors for cardiovascular and kidney diseases include hypertension, diabetes, obesity and stress. Interestingly the participation of the renin angiotensin aldosterone system (RAS) has been evid…
Cardiovascular and renal diseases are among the main "non-contagious pandemics" because they are responsible for exponential increase in morbidity and early mortality around the world. Common risk factors for cardiovascular and kidney diseases include: hypertension, diabetes, obesity and stress. Interestingly the participation of the renin angiotensin aldosterone system (RAS) has been evi…
(Only some records are available in English at this moment)
The impact of SARS-CoV-2 coronavirus infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme 2 (ACE2), which acts as the main receptor of SARS-CoV-2 in several cells and tissues, and especially in the placenta and utero-placental vessels, suggests vulnerability of this organ to viral infection during pregnancy. Beyond the risk of vertical transmission, which…
Chronic stress constitutes an alarming public health problem that causes a plenty adverse body effects. It has been observed that the stress-induced harmful effects have been worsened as a result of the coronavirus pandemic. On the other hand, it is well known that stress induces neurohumoral, metabolic and cardiovascular changes, even though those effects are dependent upon the magnitude…
Stress is one of the most significant health problems in modern society and can be defined as any disruption in homeostasis that requires an adaptive response. Due to the inherent limitations of research involving human subjects, animal models have been very useful in studying the physiological mechanisms underlying the deleterious effects triggered by stress. Although it is well establis…
The Renin-Angiotensin System (RAS) is a hormonal system associated with hydroelectrolytic homeostasis and blood pressure control, and its regulation is important in the control of renal and cardiovascular diseases. In the classical RAS pathway, the peptide angiotensin II (Ang II) is the main and most potent biologically active product of the system generated from the decapeptide Angiotens…
(Only some records are available in English at this moment)
Chronic kidney disease (CKD) has been increasingly recognized as a public health problem. Hyperglycaemia, inflammation, oxidative stress, and angiotensin signaling are molecular events that could play a mechanistic role in the development and progression of CKD. Whereas aerobic endurance training can prevent or minimize CKD complications, poor levels of physical activity and exercise into…
This project tackles angiogenesis mechanisms responsible for new vessels formation in placenta during pregnancy, which are disrupted in complications including hypertensive disorders, diabetes and obesity, as well as in fetal programming of diseases. Even though impaired angiogenesis has been shown in severe hypertensive pregnancies, till now, the understanding of the mechanisms changing …
Several cellular mechanisms participate in the development of diabetes-induced cardiac dysfunction. A role of the tissue renin-angiotensin system (RAS) in diabetic cardiomyopathy has been demonstrated by clinical and experimental studies. Diabetes is also a disease of chronic inflammation; the latter having deleterious effects on the cardiovascular function. The nuclear factor kB (NF-kB) …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 22 / 11 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 56 / 18 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 88 / 38 | All research grants and scholarships |
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