CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor in the Biochemistry Department of the Chemistry Institute of the University of Sao Paulo. PhD in Computer Science, University of Washington (1992). Full member da Sigma Xi, The Scientific Research Honor Society (USA). Research interests: bioinformatics and computational biology, primarily in genomics, metagenomics, and transcriptomics. (Source: Lattes Curriculum)
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The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
Blood vessels play a central role in the most diverse physiological and pathological processes. Over the past few years, our group has been studying two important aspects of vascular biology: the process of formation of new blood vessels by angiogenesis and the molecular heterogeneity of vascular networks in different organs and tissues of the body. Understanding the molecular mechanisms …
Healthy aging and longevity are a growing topic of interest. They depend on the complex interplay between nuclear and mitochondrial DNA, the environment and the microbiota, that is, the whole set of bacteria living in the different parts of our body with their whole set of genes. Understanding this complex nature versus nurture balance is one of the greatest challenges in human genetics a…
This project has as general objectives the collection, analysis, and investigation of molecular data from three microbiomes found in the Zoological Park of São Paulo state. These microbiomes are: Atlantic Rain Forest vegetation compost, water from a lake, and stool sample from Alouatta monkeys. The choice of microbiomes seeks to cover to some extent the environmental diversity found in th…
The goal of this project is to generate Hidden Markov Models for microbial protein families that have relevance inbioenergy. These models will allow the automated propagation of manual annotations of the genes that code for theseproteins. This project is associated with another project being carried out in the USA, which has as objectives thecreation of new Gene Ontology (GO) terms for fu…
(Only some records are available in English at this moment)
This work aims to develop a tool for classifying and annotating Metagenome-Assembled Genomes (MAGs) of prokaryotic microorganisms. Advances in DNA sequencing techniques have provided new insights into microbial diversity, including the discovery of MAGs without taxonomic classification. In this context, MAGs can be classified into three main categories: SMAGs (MAGs taxonomically classifie…
Bacteriophages (phages) are a promising alternative to combat multidrug-resistant bacteria due to their antibacterial property and host specificity1. However, this same specificity limits their application to a narrow host range. Co-evolution experiments, in which phages are exposed to both susceptible and resistant bacteria, offer a strategy to expand their host range and uncover the und…
This project aims to conduct an integrated analysis of the genomic diversity and pangenome of bacterial genera present in the metagenomic dataset from MetaSUB project. For this purpose, we will use the simulated rarefaction curve technique along with the non-parametrics estimators Chao1, Chao2, Jackknife, ICE, and ACE, to estimate the total number of species within the target genera in th…
(Only some records are available in English at this moment)
Angiogenesis is the creation of new blood vessels from pre-existing ones. It occurs naturally in physiological and pathological process, such as retinopathies and cancer. Through RNA sequencing (RNA-Seq), it is possible to study these differences between tissues at cell level in the moment of sequencing. RNA-seq data enables the identification and quantification of gene expression of the …
Angiogenesis is the process which new blood vessels form from pre-existing vessels. Many diseases are dependent of neovascularization to growth in the organism, like Cancer and retinopathies. These diseases are known as angiogenesis-dependent diseases. The formation of blood vessels in a adult organism occur under delicate control of gene expression, and dysregulation of this process coul…
Diabetes Mellitus Type 02 (DM2) is a metabolic disease characterized by hyperglycemia derived from defects in the action of insulin and accounts for between 90-95% of cases of the disease. Its manifestation is dependent on mutant alleles at multiple gene loci; at the present time, there are at least 128 distinct signs of association with DM2 attributed to 113 loci. Due to the high prevale…
(Only some records are available in English at this moment)
Phages, the viruses of bacteria, are capable of establishing either antagonistic or mutualistic interactions with their hosts. Evidence so far clearly demonstrates the importance of phages for microbiome functioning. However little is known about how phage-bacteria interactions at the community-level respond to environmental changes. Environmental disturbances can change microbial communi…
Colorectal cancer (CRC) is the third most common cancer in the world, affecting more than 1.3 million people every year. CRCs can be divided into sporadic, inflammatory and hereditary forms. Genetics can, however, explain only a small proportion of disease variance. Using 16S rRNA amplicon sequencing, several bacterial species have been implicated in the development of CRC, but high-resol…
Phages studies have been experiencing a resurgence of scientific interest due to recent evidences that show their importance in microbial ecology, carbon and other nutrients cycling and potential applications as anti-bacterial therapeutics in clinical, agricultural and food processing fields. They are also theorized as Nature reservoirs of genetic diversity, being responsible for new gene…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 8 / 4 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 30 / 10 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 52 / 27 | All research grants and scholarships |
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