Juliana Maldonado Marchetti

• Abstract

  Prostate cancer is the most prevalent type of cancer in men, but its therapy is associated with many effects and limited effectiveness. Docetaxel is one of the first choice antitumor drugs used in conventional therapy for several types of cancer - including prostate - but it presents severe side effects. Pharmaceutical technology has been using important strategies for the purpose of turn…

  Development and characterization of delivery systems containing docetaxel for optimization of prostate cancer therapy: imunoliposomes and polymeric nanoparticles, AP.R

• Abstract

  Ovarian cancer (adenocarcinoma) occurs in 50% of cases of malignant tumors of the ovaries and presents bilaterally in 30-50% of patients. The highest lethality of this cancer is due to late diagnosis. In Brazil, 6,000 new cases were estimated in 2012, and in 2010, approximately 3,000 deads. This type of cancer tends to be aggressive and do not have a test to detect "early" and most patien…

  Development and characterization of nanoparticles with polycaprolactone containing paclitaxel targeted with bevacizumab for optimization of ovarian cancer therapy, AP.R

• Abstract

  Breast cancer represents a severe problem in public health, representing a major cause of death among women. Among the drugs employed in therapy, we highlight paclitaxel, a cytotoxic drug presenting high potency and efficacy, but associated with severe side effects and commercially available in a formulation that presents considerable toxicity. Recently, metformin, tradionally used to tre…

  Strategies for paclitaxel and metformin vehiculation to improve breast cancer therapy: liposomes and dendrimers, AP.R

(Only some records are available in English at this moment)

• Abstract

  Ovarian cancer is the most lethal gynecologic malignancy. It is estimated that in the year 2020 about 7,162 women will be diagnosed with ovarian cancer and the average mortality in the same year is estimated in 4,905 deaths. The high lethality is related with the lack of specific symptoms and a reliable early detection tests. Thus, approximately 70% of all patients are diagnosed with adva…

  Development and characterization of PLGA nanoparticles containing paclitaxel targeted with f olate for optimization of ovarian cancer therapy, BP.MS

• Abstract

  Prostate cancer is the second most incident type of cancer among men. Only in Brazil, 61.200 new cases are expected to be diagnosed in 2016. Though a huge progress has been observed on the prostate cancer treatment over the last few decades, this pathology keeps being the second highest cause of deaths related to cancer among men. Regarding the indicated drugs for the treatment of this p…

  e-polycaprolactone and D-±-tocopherol polyethylene glycol-1000 nanoparticles containing docetaxel aiming prostate cancer therapy, BP.MS

• Abstract

  Cancer is currently considered one of the most lethal diseases; it happens because of malfunction of genes that control cell growth and division, being the second most deadly disease in the United States with 580,000 deaths estimated in 2013. Ovarian cancer (adenocarcinoma) is the fourth cause of death from cancer. And for being the most lethal gynecologic tumors, was responsible for 3,02…

  Development and characterization of polycaprolactone nanoparticles containing paclitaxel: a potential delivery system for the treatment of ovarian cancer, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Ovarian cancer (adenocarcinoma) occurs in 50% of cases of malignant tumors of the ovaries and presents bilaterally in 30-50% of patients. The highest lethality of this cancer is due to late diagnosis. In Brazil, 6,000 new cases were estimated in 2012, and in 2010, there were approximately 3,000 deaths. This type of cancer tends to be aggressive and does not have a test to detect "early" a…

  Folate-targeted polymeric nanoparticles for ovarian cancer, BE.EP.DR

• Abstract

  Breast cancer represents an important problem in public health, being one of the leading causes of death among women. Among the drugs used in the therapy, one of the most employed is paclitaxel, a cytotoxic agent with high potency and efficacy; however, it is associated with several side effects, because of drug and also due to the formulation composition. Recently, the observation that d…

  Functionalization of liposomes containing metformin and paclitaxel with trastuzumab: development, characterization and evaluation of efficacy against breast cancer, BE.EP.DR