Abstract
The aim of this project is to describe the application plan of the School of Pharmaceutical Sciences for the grant related to the "Reserva Técnica Institucional" of Fapesp. (AU)
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Marcia Aparecida Silva Graminha
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológica from Universidade de São Paulo (1994), master's at Genetics from Universidade de São Paulo (1998) and ph.d. at Genética from Universidade de São Paulo (2002). Has experience in Genetics, focusing on Molecular Genetics and of Microorganisms, acting on the following subjects: bioinformatics, gene expression regulation, fungi, aspergillus nidulans and drug resistance. (Source: Lattes Curriculum)
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Research grants
- Therapeutics for leishmaniasis: from screening to the study of mechanisms of action, a contribution to the discovery of new antileishmanial molecules, AP.R
Abstract
Leishmaniasis is a pathogenic disease found throughout the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance to them makes providing new therapeutic alternatives urgen…
- Leishmaniasis: from screening to the study of mechanisms of action, a contribution to the discovery of new bioactive molecules, AP.R
Abstract
Leishmaniasis is a pathogenic disease found throughout the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance to them makes providing new therapeutic alternatives urgen…
- Leishmaniasis and bioinorganic compounds containing Au(I) and Pd(II): antileishmanial activities, mechanims of action and putative new drug targets, AP.R
Abstract
The World Health Organization (WHO) estimates that more than one billion people suffer from neglected tropical diseases. Leishmaniasis is a widespread disease, affecting 12 million people around the world with about 1-2 million estimated new cases occurring every year. For more than 60 years, pentavalent antimonials, Sb (V) compounds, have been the first-line chemotherapy against leishman…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Construction and Characterization of a Genetically Modified Leishmania to Constitutively Express The Fluorescent Protein Yellow Cameleon-nano50: A Tool for AntiLeishmanial Compounds Screening that Might Interfer in the Parasite Calcium Homeostasis, BP.IC
Abstract
Leishmaniasis is a vector borne disease caused by several species of protozoa belonging to the genus Leishmania. Leishmaniasis present diverse clinical manifestations and are considered a public health issue in the world, with Brazil being an endemic country in the region. Currently the few available drugs for the treatment of Leishmaniasis are associated with severe side effects, high to…
- ANTILEISHMANIAL PEPTIDES: PLANNING, SYNTHESIS, CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF NEW SYNTHETIC PEPTIDES DIRECTED TO THE MCU (MITOCHONDRIAL CALCIUM UNIPORTER) MOLECULAR TARGET OF LEISHMANIA, BP.IC
Abstract
Leishmaniasis is a highly prevalent neglected disease caused by more than 20 species of protozoan parasites of the genus Leishmania (order: Kinetoplastida; family: Trypanosomatidae) transmitted by the bite of sandflies. The therapeutic treatment of leishmaniasis has several drawbacks, from the limited diversity of drugs currently available to high toxicity, which makes the search for new …
- Identification of peptides capable of inhibiting the internalization process of Leishmania braziliensis promastigotes in differentiated macrophage cells., BP.IC
Abstract
Leishmaniases are considered Neglected Diseases, resulting from infection by protozoa of the genus Leishmania, being endemic in large areas of the tropics, subtropics and Mediterranean basin, affecting more than 98 countries. According to the World Health Organization, around one billion people live in areas endemic for leishmaniasis and are at risk of acquiring the infection. The organiz…
- Characterization of Leishmania infantum - macrophage interaction: Identification of binding proteins in L. infantum through synthetic peptides selected by phage display technique, BP.IC
Abstract
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania and endanger 350 million people worldwide. There are few available drugs for the treatment of this parasitic disease that present several drawbacks such as high toxicity and low efficacy, turning urgent the search for new drugs. The transmission occurs by the inoculation of metacyclic promastigotes into the h…
- Therapeutics for leishmaniasis: from screening to the study of mechanisms of action, a contribution to the discovery of new antileishmanial molecules, BP.TT
(Only some records are available in English at this moment)
Scholarships abroad
- New insight into the mechanism of action of CP2 in Leishmania: analysis of calcium homeostasis and the respiratory chain, BE.EP.PD
Abstract
Leishmaniasis is a neglected disease that remains a major health problem around the word. A limited number of effective antileishmanial drugs are available for chemotherapy, and many of them are associated with high toxicity, difficult administration route and low efficacy. Therefore, there is an urgent need to develop a novel safe and effective antileishmanial drug. Previously, we report…
- Natural and/or bioinorganinc compounds as possible LiTOP1B inhibitors: an evaluation, BE.PQ
Abstract
Leishmaniasis affects millions of people worldwide and is considered one of Neglected Tropical Diseases (NTDs) by affecting mainly the populations in developing countries. There are few drugs available for the treatment of leishmaniasis, which are toxic and often ineffective due to the emergence of resistant strains, thus the search for new compounds with leishmanicidal activity is justif…
- Proteomic analysis of Leishmania mexicana by permeabilization of different cell membranes with digitonin, BE.EP.IC
Abstract
The leishmaniasis are a group of diseases caused by the genus Leishmania. These affect 350 million people in the world in its two main forms, the cutaneous leishmaniasis and visceral leishmaniasis. After the complete sequencing of the genome of Leishmania major and the breakthrough in sequencing other species (Leishmania braziliensis, L. mexicana and L. infantum), much has been advanced r…
(Only some records are available in English at this moment)
Total / Available in English
| 1 / 1 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 11 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 25 / 22 | All research grants and scholarships |
| Associated processes | |
- Camila Tita Nogueira
- Mayara Lúcia Del Cistia
- Angela Maria Arenas Velásquez
- Maysa Alves de Oliveira
- Marina Pasetto Nobrega
- Nilce Maria Martinez-Rossi
- Angela Kaysel Cruz
- Karoline Mathias Leite
- Evelin Costa Lima
- Jéssica Naiara Varonez da Fonseca
- Daphne Duberger Lopes Teodoro
- Eduarda de Carvalho Le Sénéchal Horta