CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Instituto de Biociências da USP (2004) and doctorate at Ciências Biológicas from Instituto de Biociências da USP (2010). Has experience in Biochemistry, acting on the following subjects: thiolate, cysteine, sulfenic acid and peroxidases. (Source: Lattes Curriculum)
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Inositol polyphosphates and pyrophosphates (IPs and PP-IPs) constitute a ubiquitous class of highly charged and water-soluble molecules conserved from yeast to humans, playing fundamental roles in cellular homeostasis and implicated in human diseases such as diabetes and cancer. Despite their greater diversity compared to lipid phosphoinositides, IPs remain less characterized to date. In …
The genomic damage response is a network of cellular pathways which are responsible to sense, signal and activate chromatin repair and tolerance pathways. As part of this response, the protein quinase Mec1 (ATR in humans) coordinates the DNA damage checkpoint signaling pathway (DDC). Mec1 activation results in the regulation by phosphorylation of several proteins responsible to modulate m…
Abstract: The Kcs1 protein (IP6K1/2/3 in humans) is an inositol pyrophosphate kinase responsible for the synthesis of inositol pyrophosphates (PP-IPs). PP-IPs are a ubiquitous class of highly charged, water-soluble molecules conserved from yeast to humans, playing essential roles in cellular homeostasis. Phosphoproteomic studies have identified Kcs1 as a phosphoprotein, being phosphorylat…
Inositol polyphosphates (IPs) represent an ubiquitous class of highly charged, water-soluble molecules conserved from yeast to humans, playing fundamental roles in cellular homeostasis and implicated in human diseases such as diabetes and cancer. Despite their greater diversity compared to lipid phosphoinositides, IPs remain less characterized. In recent years, attention has been focused …
The DNA Damage Response (DDR) contribute to genomic stability through the modulation of a myriad of cellular pathways that are responsible to detect DNA lesions, promote DNA Damage signaling and active DNA repair and DNA damage tolerance mechanisms. Besides that, it also modulates another cellular responses such as protein homeostasis and metabolism of biomolecules such as carbohydrates a…
Chromatin damages can be caused by a series of endogenous and exogenous factors that lead to alterations and breaks on DNA, replication forks collapse, histones and other nucleus' proteins damage, besides other organelles damages such asmitochondria's with consequent increase of oxygen and nitrogen reactive species (ORSs and NRSs). Failure in appropriate cellular response during genotoxic…
The response to genomic damage involves several effector proteins that act in many cellular processes promoting adaptations and changes in the organism and its genomes, such as re-establishment of nuclear function (through DNA lesions repair and nuclear proteins) and cellular metabolic reprogramming. Failures to trigger an appropriate cellular response during the genotoxic stress can lead…
Chromatin can be damaged by several factors form endogenous or exogenous sources, which can lead to DNA breaks, replication fork stall and collapse and histone and other proteins modifications. The DNA damage responses (DDR) consist of several protein effectors that regulate several cellular processes with the ultimate goal to prevent genomic instability and loss of cell viability. The Op…
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Inositol pyrophosphates are energy-rich signaling molecules derived from inositol conserved from yeast to humans. They regulate and control cellular homeostasis by modulating cellular responses through interactions with target proteins via two distinct mechanisms: i) allosteric interactions with protein domains such as PH (Pleckstrin Homology) domains, and ii) non-enzymatic pyrophosphoryl…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 13 | All research grants and scholarships |
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