CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Coréia do Sul
I graduated in Chemistry, Master and Doctorate in Biochemistry in the University of São Paulo, and was postdoctoral fellow in the University of Washington working on gene therapy. I was a professor of biochemistry in the Unesp between 1988-1996 and since 1996 I am a professor of Biophysics in the Escola Paulista de Medicina - Unifesp. Currently, I am a full professor of this university. I was co-founder of the Interdisciplinary center for Gene Therapy (CINTERGEN) in 2004 in the Unifesp, and had been director of this center since its foundation until 2010. The name CINTERGEN was changed to CTCMol. I am a member of the Technical Chamber of Advanced Therapies at ANVISA and representative of specialists at RENETA-ANVISA. Since 2019, I have been vice president of the Brazilian Association of Cell and Gene Therapy. The main research lines are: gene therapy of ischemic diseases, genetic diseases, cancer and DNA vaccine. Link to my Google Scholar is https://scholar.google.com.br/citations?user=j9dfSOEAAAAJ&hl=en (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Scientists test gene therapy for mucopolysaccharidosis |
The main objective of the current thematic project of FAPESP is to study the relationship between the colony- stimulating factors (CSFs) and the type of monocytes/macrophages recruited under normoxia and hypoxia, and to elaborate procedures of gene and cell therapy of ischemic diseases by recruiting more proresolutive macrophages or by implanting proresolutive macrophages genetically engi…
Peripheral arterial disease affects millions of people every year and compromises the quality of life and shortens the life expectancy of these patients. The non-healing ulcer and strong chronic pain are the main symptoms of this disease in advanced stage that occurs due to tissue hypoperfusion and can lead to amputation of the affected limb and death. In the ischemic limb a constant infl…
The carcinoembryonic antigen (CEA) is a tumor marker for cancers of epithelial origin, which is expressed during embryonic life and is present in some normal adult tissues: consequently, CEA is recognized as a self-antigen by the immune system. The replacement of antigen for immunization by anti-idiotypic antibody has been considered a promising strategy to break tolerance in some types o…
Muscle injury is one that occurs most often among athletes and is the main reason for the abandonment of their activities. Repair of the damaged muscle tissue is a slow process and often incomplete due to exacerbated fibrosis. For tissue repair needs of angiogenesis (also arteriogenesis and vasculogenesis), myogenesis and fibrogenesis in sync, and these processes are regulated by several …
(Only some records are available in English at this moment)
Peripheral arterial disease is characterized by the narrowing of peripheral vessels, and can advance to Critical Limb Ischemia (CLI). Within a year, 25% of patients die and 30% suffer amputation due to the lack of therapeutic options. The two main pathophysiological changes that occur in ischemic tissue are the decrease in blood flow and the increase in inflammation, which need to be addr…
The main targets of thematic project are the modulation of macrophages by CSFs to promote the formation of M2 macrophages. These cells produce a series of growth factors, which promote vessel formation and remodeling, and myogenesis in ischemic and inflamed skeletal muscle. The main oxygen sensor in cells is the proline hydroxylase of HIF (Hypoxia Inducible Factor), which is called the PH…
The critical limb ischemia (CLI) is characterized by the narrowing of arteries from lower limbs. It is being estimated that 25% of patients diagnosticated with CLI will die and others 30% will receive amputation within a year. The CLI available treatments are limited due co-morbidities and advanced age of patients, thus, it is necessary to develop new alternative therapies. Among these, t…
The proposed thematic project aims to study the effect of colony stimulating factors (CSFs) on the modulation of macrophages, monocytes and pericytes, since we and other groups have seen that CSFs have the activity of forming new vessels and remodeling blood vessels. In addition, we observed the anti-fibrotic and pro-myogenic activities, which is not a consensus with other groups. Thus, i…
Peripheral arterial disease (PAD) has a prevalence of 10% in population, and the people over 70 year-old the prevalence can reach 20%. The main cause of PAD is atherosclerosis, which leads to obstruction of vessels, generating ischemia and chronic critical limb ischemia (ICC) in long-term. The ICC compromises the physical and functional integrity of the patient and may lead to limb loss a…
(Only some records are available in English at this moment)
Peripheral arterial disease (PAD) is a circulatory disorder caused by atherosclerosis, which affects millions of people every year. In the advanced stage of PAD, this disease evolves to critical limb ischemia (CLI) which severely affects the limb's blood circulation, causing pain at rest and nonhealing wounds. Therefore, the promotion of angiogenesis and control of inflammation should fav…
Fibrosis is a major acquired sequel after muscle. The fibrotic process prevents proper muscle contraction and can lead to muscle contractures and chronic pain. In more severe injuries, in which healing occurs slowly, fibrosis prevents the proper muscle contraction and can lead to chronic pain and muscle contractures. In addition to functional loss, scar tissue tends to suffer further inju…
The monogenic RDEB is a very aggressive disease with no effective treatment yet. As patients suffering exclusively RDEB deficiency of collagen VII, the logical solution would be to provide this protein in the skin/epithelium continously throughout their lives, but how this solution can become a reality? Our proposal is to use hematopoietic stem cells from bone marrow to express the COL7…
| 2 / 2 | Ongoing research grants |
| 12 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 32 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 51 / 32 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 25 |
| Citations | 175 |
| Cit./Article | 7.0 |
| Data from Web of Science | |
SACRAMENTO, CHESTER BITTENCOURT; CANTAGALLI, VANESSA DIONISIO; GRINGS, MARIANA; CARVALHO, LEONARDO PINTO; COSTA BAPTISTA-SILVA, JOSE CARLOS; BEUTEL, ABRAM; BERGAMASCHI, CASSIA TOLEDO; DE CAMPOS JUNIOR, RUY RIBEIRO; DE MORAES, JANE ZVEITER; TAKIYA, CHRISTINA MAEDA; et al. Granulocyte-macrophage colony-stimulating factor gene based therapy for acute limb ischemia in a mouse model. JOURNAL OF GENE MEDICINE, v. 11, n. 4, p. 345-353, APR 2009. Web of Science Citations: 11.
MCNEILL INGHAM, SHEILA JEAN; POCHINI, ALBERTO DE CASTRO; DE OLIVEIRA, DANIEL ANTONIO; GARCIA LISBOA, BIANCA CRISTINA; BEUTEL, ABRAM; VALERO-LAPCHIK, VALDEREZ BASTOS; FERREIRA, ANA MARIA; ABDALLA, RENE JORGE; COHEN, MOISES; HAN, SANG WON. Bupivacaine Injection Leads to Muscle Force Reduction and Histologic Changes in a Murine Model. PM&R, v. 3, n. 12, p. 1106-1109, DEC 2011. Web of Science Citations: 7. (11/00859-6)
MATSUMOTO MARTIN, PRISCILA KEIKO; STILHANO, ROBERTA SESSA; SAMOTO, VIVIAN YOCHIKO; TAKIYA, CHRISTINA MAEDA; PERES, GIOVANI BRAVIN; CORREA DA SILVA MICHELACCI, YARA MARIA; DA SILVA, FLAVIA HELENA; PEREIRA, VANESSA GONCALVES; D'ALMEIDA, VANIA; NAVARRO MARQUES, FABIO LUIZ; et al. Mesenchymal Stem Cells Do Not Prevent Antibody Responses against Human alpha-L-Iduronidase when Used to Treat Mucopolysaccharidosis Type I. PLoS One, v. 9, n. 3, MAR 18 2014. Web of Science Citations: 6. (08/56529-1, 09/52235-6, 08/56530-0)
CUNHA, FLAVIA FRANCO; MARTINS, LEONARDO; MATSUMOTO MARTIN, PRISCILA KEIKO; STILHANO, ROBERTA SESSA; HAN, SANG WON. A comparison of the reparative and angiogenic properties of mesenchymal stem cells derived from the bone marrow of BALB/c and C57/BL6 mice in a model of limb ischemia. STEM CELL RESEARCH & THERAPY, v. 4, JUL 26 2013. Web of Science Citations: 9. (11/00859-6)
STILHANO, ROBERTA SESSA; MATSUMOTO MARTIN, PRISCILA KEIKO; DE MELO, SUELY MAYMONE; SAMOTO, VIVIAN YOCHIKO; PERES, GIOVANI BRAVIN; CORREA DA SILVA MICHELACCI, YARA MARIA; DA SILVA, FLAVIA HELENA; PEREIRA, VANESSA GONCALVES; D'ALMEIDA, VANIA; DA CRUZ, ADRIANA TAVEIRA; et al. alpha-L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice. JOURNAL OF GENE MEDICINE, v. 17, n. 1-2, p. 1-13, JAN-FEB 2015. Web of Science Citations: 3. (09/52235-6)
MADRIGAL, JUSTIN L.; STILHANO, ROBERTA S.; SILTANEN, CHRISTIAN; TANAKA, KIMBERLY; REZVANI, SABAH N.; MORGAN, RYAN P.; REVZIN, ALEXANDER; HAN, SANG W.; SILVA, EDUARDO A.. Microfluidic generation of alginate microgels for the controlled delivery of lentivectors. JOURNAL OF MATERIALS CHEMISTRY B, v. 4, n. 43, p. 6989-6999, NOV 21 2016. Web of Science Citations: 10. (12/00753-6, 15/20206-8)
STILHANO, ROBERTA SESSA; SAMOTO, VIVIAN YOCHIKO; SILVA, LEONARDO MARTINS; PEREIRA, GUSTAVO JOSE; ERUSTES, ADOLFO GARCIA; SMAILI, SORAYA SOUBHI; HAN, SANG WON. Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor. PLoS One, v. 12, n. 10, OCT 23 2017. Web of Science Citations: 1. (12/00753-6, 15/20206-8)
TENG, YUAN-CHI; PORFIRIO-SOUSA, ALFREDO LEONARDO; RIBEIRO, GIULIA MAGRI; AREND, MARCELA CORSO; MEIRELLES, LINDOLFO DA SILVA; CHEN, ELIZABETH SUCHI; ROSA, DANIELA SANTORO; HAN, SANG WON. Analyses of the pericyte transcriptome in ischemic skeletal muscles. STEM CELL RESEARCH & THERAPY, v. 12, n. 1, MAR 16 2021. Web of Science Citations: 0. (17/17588-1, 15/20206-8)
MARTINS, LEONARDO; GALLO, CAMILA CONGENTINO; HONDA, TAMISA SEEKO BANDEIRA; ALVES, PATRICIA TERRA; STILHANO, ROBERTA SESSA; ROSA, DANIELA SANTORO; KOH, TIMOTHY JON; HAN, SANG WON. Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF. STEM CELL RESEARCH & THERAPY, v. 11, n. 1, NOV 6 2020. Web of Science Citations: 0. (16/04229-0, 11/15417-9, 18/09203-5)
MERTINS, OMAR; LOBO, SONJA ELLEN; MATHEWS, PATRICK D.; HAN, SANG WON. Interaction of pDNA with reverse phase chitosome. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 543, p. 76-82, APR 20 2018. Web of Science Citations: 0. (16/13368-4, 15/20206-8, 15/23948-5)
STILHANO, ROBERTA S.; MADRIGAL, JUSTIN L.; WONG, KEVIN; WILLIAMS, PRISCILLA A.; MARTIN, PRISCILA K. M.; YAMAGUCHI, FABIO S. M.; SAMOTO, VIVIAN Y.; HAN, SANG W.; SILVA, EDUARDO A.. Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle. JOURNAL OF CONTROLLED RELEASE, v. 237, p. 42-49, SEP 10 2016. Web of Science Citations: 17. (15/20206-8)
DE CARVALHO, BRUNA GREGATTI; TAKETA, THIAGO BEZERRA; MORENO GARCIA, BIANCA BONETTO; HAN, SANG WON; DE LA TORRE, LUCIMARA GAZIOLA. Hybrid microgels produced via droplet microfluidics for sustainable delivery of hydrophobic and hydrophilic model nanocarriers. Materials Science & Engineering C-Materials for Biological Applications, v. 118, JAN 2021. Web of Science Citations: 0. (18/19537-8, 15/20206-8, 18/18523-3)
MEIRELLES, LINDOLFO DA SILVA; MARSON, RENAN FAVA; GONZALEZ SOLARI, MARIA INES; NARDI, NANCE BEYER. Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair. CELLS, v. 9, n. 1, JAN 2020. Web of Science Citations: 0. (15/20206-8)
DE CARVALHO‚ L.P.; TAKESHITA‚ D.; CARILLO‚ B.A.; LISBÔA‚ B.C.G.; MOLINA‚ G.; BEUTEL‚ A.; YASUMURA‚ E.G.; TAKIYA‚ C.M.; VALERO‚ V.B.; DE CAMPOS‚ JR‚ R.R.; et al. Hydrodynamics-and ultrasound-based transfection of heart with naked plasmid DNA. Human Gene Therapy, v. 18, n. 12, p. 1233-1243, 2007.
SACRAMENTO, C. B.; MORAES, J. Z.; DENAPOLIS, P. M. A.; HAN, S. W.. Gene expression promoted by the SV40 DNA targeting sequence and the hypoxia-responsive element under normoxia and hypoxia. Brazilian Journal of Medical and Biological Research, v. 43, n. 8, p. 722-727, AUG 2010. Web of Science Citations: 12.
YASUMURA, EDUARDO GALLATTI; STILHANO, ROBERTA SESSA; SAMOTO, VIVIAN YOCHIKO; MATSUMOTO, PRISCILA KEIKO; DE CARVALHO, LEONARDO PINTO; VALERO LAPCHIK, VALDEREZ BASTOS; HAN, SANG WON. Treatment of Mouse Limb Ischemia with an Integrative Hypoxia-Responsive Vector Expressing the Vascular Endothelial Growth Factor Gene. PLoS One, v. 7, n. 3, p. e33944, 2012. Web of Science Citations: 9. (11/00859-6)
BENTES DE PAULA, DAISY MARIA; VALERO-LAPCHIK, VALDEREZ BASTOS; PAREDES-GAMERO, EDGAR JULIAN; HAN, SANG WON. Therapeutic ultrasound promotes plasmid DNA uptake by clathrin-mediated endocytosis. JOURNAL OF GENE MEDICINE, v. 13, n. 7-8, p. 392-401, JUL-AUG 2011. Web of Science Citations: 28.
CHOUDHURI, JOMUNA V.; MATHOR, MONICA B.; SILVA, FLAVIA H.; HAN, SANG W.. Autonomous growth of BALB/MK keratinocytes transfected with a retroviral vector carrying the human epidermal growth factor gene. GENETICS AND MOLECULAR BIOLOGY, v. 31, n. 4, p. 824-828, 2008. Web of Science Citations: 2.
ROSEGUINI, BRUNO T.; SILVA, LEONARDO M.; POLOTOW, TATIANA G.; BARROS, MARCELO P.; SOUCCAR, CADEN; HAN, SANG W.. Effects of N-acetylcysteine on skeletal muscle structure and function in a mouse model of peripheral arterial insufficiency. JOURNAL OF VASCULAR SURGERY, v. 61, n. 3, p. 777-786, MAR 2015. Web of Science Citations: 7. (10/51344-3, 11/18197-0, 11/00859-6)
BENTO‚ F.; TAKESHITA‚ D.; SACRAMENTO‚ C.; MACHADO‚ T.; MATHOR‚ M.; CARMONA‚ A.; HAN‚ S.. Over expression of the selectable marker blasticidin S deaminase gene is toxic to human keratinocytes and murine BALB/MK cells. BMC Biotechnology, v. 4, n. 1, p. 29, 2004.
DENAPOLI, PRISCILA M. A.; ZANETTI, BIANCA F.; DOS SANTOS, ADARA A.; DE MORAES, JANE Z.; HAN, SANG W.. Preventive DNA vaccination against CEA-expressing tumors with anti-idiotypic scFv6.C4 DNA in CEA-expressing transgenic mice. CANCER IMMUNOLOGY IMMUNOTHERAPY, v. 66, n. 3, p. 333-342, MAR 2017. Web of Science Citations: 3. (12/21861-1)
DE MELO, SUELY MAYMONE; BITTENCOURT, SIMONE; FERRAZOLI, ENEAS GALDINI; DA SILVA, CLIVANDIR SEVERINO; DA CUNHA, FLAVIA FRANCO; DA SILVA, FLAVIA HELENA; STILHANO, ROBERTA SESSA; ANDRADE DENAPOLI, PRISCILA MARTINS; ZANETTI, BIANCA FERRARINI; MATSUMOTO MARTIN, PRISCILA KEIKO; et al. The Anti-Tumor Effects of Adipose Tissue Mesenchymal Stem Cell Transduced with HSV-Tk Gene on U-87-Driven Brain Tumor. PLoS One, v. 10, n. 6, JUN 12 2015. Web of Science Citations: 26. (12/21861-1)
MARTINS, GRAZIELI OLINDA; PETRONIO, MAICON SEGALLA; FURUYAMA LIMA, ALINE MARGARETE; MARTINEZ JUNIOR, ANDRE MIGUEL; DE OLIVEIRA TIERA, VERA APARECIDA; CALMON, MARILIA DE FREITAS; LEITE VILAMAIOR, PATRICIA SIMONE; HAN, SANG WON; TIERA, MARCIO JOSE. Amphipathic chitosans improve the physicochemical properties of siRNA-chitosan nanoparticles at physiological conditions. Carbohydrate Polymers, v. 216, p. 332-342, JUL 15 2019. Web of Science Citations: 3. (17/10331-5, 12/24259-0, 15/05148-1, 15/20206-8)
SHELDON, RYAN D.; ROSEGUINI, BRUNO T.; LAUGHLIN, M. HAROLD; NEWCOMER, SEAN C.. New insights into the physiologic basis for intermittent pneumatic limb compression as a therapeutic strategy for peripheral artery disease. JOURNAL OF VASCULAR SURGERY, v. 58, n. 6, p. 1688-1696, DEC 2013. Web of Science Citations: 10. (11/18197-0)
DA CUNHA, FLAVIA FRANCO; MARTINS, LEONARDO; MATSUMOTO MARTIN, PRISCILA KEIKO; STILHANO, ROBERTA SESSA; PAREDES GAMERO, EDGAR JULIAN; HAN, SANG WON. Comparison of treatments of peripheral arterial disease with mesenchymal stromal cells and mesenchymal stromal cells modified with granulocyte and macrophage colony-stimulating factor. CYTOTHERAPY, v. 15, n. 7, p. 820-829, JUL 2013. Web of Science Citations: 10. (11/00859-6)
DE MELLO, LUCAS RODRIGUES; HAMLEY, IAN WILLIAM; CASTELLETTO, VALERIA; MORENO GARCI, BIANCA BONETTO; HAN, SANG WON; PINTO DE OLIVEIRA, CRISTIANO LUIS; DA SILV, EMERSON RODRIGO A. Nanoscopic Structure of Complexes Formed between DNA and the Cell-Penetrating Peptide Penetratin. Journal of Physical Chemistry B, v. 123, n. 42, p. 8861-8871, OCT 24 2019. Web of Science Citations: 0. (15/20206-8, 16/24409-3)
ZANETTI, BIANCA FERRARINI; FERREIRA, CAMILA PONTES; CARVALHO DE VASCONCELOS, JOSE RONNIE; HAN, SANG WON. scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor. Gene Therapy, v. 26, n. 10-11, p. 441-454, NOV 2019. Web of Science Citations: 0. (13/17224-9, 12/21861-1)
CARVALHO, BRUNA G.; VIT, FRANCIELE F.; CARVALHO, HERNANDES F.; HAN, SANG W.; DE LA TORRE, LUCIMARA G.. Recent advances in co-delivery nanosystems for synergistic action in cancer treatment. JOURNAL OF MATERIALS CHEMISTRY B, v. 9, n. 5, p. 1208-1237, FEB 7 2021. Web of Science Citations: 1. (18/18523-3, 15/20206-8, 18/19537-8)
SANG WON HAN; CARLOS ALBERTO VERGANI JUNIOR; PAULO EDUARDO OCKE REIS. Terapia gênica de isquemia de membro é uma realidade?. Jornal Vascular Brasileiro, v. 19, p. -, 2020. (15/20206-8)
GARCIA, BIANCA B. M.; MERTINS, OMAR; DA SILVA, EMERSON R.; MATHEWS, PATRICK D.; HAN, SANG W.. Arginine-modified chitosan complexed with liposome systems for plasmid DNA delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 193, SEP 2020. Web of Science Citations: 1. (15/20206-8, 15/23948-5, 16/13368-4)