CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Israel
Graduated in Biochemistry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He obtained his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry and Vice-Director of the Institute of Chemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces, to organize biofilm structures as well as to interact with bacteriophages. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks. Dr. Farah is the Director of the Biology of Bacteria and Bacteriophages Research Center (CEPID B3), a research network with hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) whose mission is to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interactions with their eukaryotic hosts and their main predators, the bacteriophages. (Source: Lattes Curriculum)
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The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
Vitrobot (Vitrification Robot) is a fully PC controlled device for vitrification (rapid cooling) of aqueous samples deposited on a cryo-EM grid. The instrument is designed to consistently produce excellent specimens for cryo-electron microscopy. The immersion, stain and vitrification process is fully automated after placing a vial in the chamber and installing the coolant container. The o…
(Only some records are available in English at this moment)
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
The aim of the São Paulo Advanced Science School in CryoEM is to bring together young students and researchers from around the world to cover the basic principles involved in the determination of macromolecular structures by Cryo Electron Microscopy and Cryo Electron Tomography. Time will be divided between lectures covering theory, demonstrations and hands-on practical sessions on proces…
Xanthomonas citri subsp citri is a bacterial phytopathogen that causes citrus canker disease, one of significant economic importance around the world. X. citri spreads from affected plants to healthy plants mainly through rain and wind and has the ability to survive for long periods on different surfaces usually due to the formation of biofilms. The bacterial biofilm is a highly regulated…
(Only some records are available in English at this moment)
The type IV secretion system found in the phytopathogen Xanthomonas citri (X-T4SS) functions as a powerful nanomachine that plays a crucial role in bacterial competition, primarily mediating the secretion of toxins into other cells. The nuclease X-TfeXAC3266, predicted to act in the cytosol of the target cell, has a theoretical molecular mass of 92.5 kDa and contains AHH and XVIPCD protei…
(Only some records are available in English at this moment)
Cyanide is widely used in industries due to its high affinity for metals. This characteristic is at the same time responsible for the potent toxicity of this compound. Thus, industries have to reduce the cyanide concentration from wastewater before its final disposal. Physical, chemical and biological methods have been developed to achieve this goal, but knowledge about metabolic pathways…
Type IV Secretion systems (T4SS) are macromolecular protein complexes in bacteria which, encompassing the membranes, mediate the exchange of DNA and protein effectors to target cells, playing a key role in conjugation, bacterial competition, eukaryotic cell invasion and immune system evasion in different species. In the last fifteen years, our group have been studying the role of bacteria…
The pili of T2SS, T3SS, T4SS and T4P mediate the attachment of bacteria to other structures which can be other cells, phages or inanimate surfaces. This attachment can often lead to the transfer of virulence factors, invasion by a phage or the formation of biofilms. Type IV pili are specialized versions type II secretion systems (T2SSs) that translocate folded proteins from the periplasm …
(Only some records are available in English at this moment)
Bacteria use different secretion systems for protein transportation into other bacteria, eukaryotic cells or for secretion to the extracellular medium. Among them, the type IV secretion system, T4SS, is perhaps the most versatile, being present in both Gram-positive and Gram-negative bacteria, being also capable of transporting protein-DNA complexes, in this way mediating horizontal gene …
One of the main objectives of this postdoctoral project is to obtain structural information regarding the Xac Type IV Secretion System core complex, which forms the pore through both the inner and outer membrane layers of the bacterial envelope. This complex is made up of 14 copies each of VirB7, VirB9, and VirB10 subunits. Due to the core complex's large size (~1.2 MDa) and association w…
| 5 / 5 | Ongoing grants |
| 18 / 12 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 39 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 73 / 43 | All research grants and scholarships |
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