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Shaker Chuck Farah

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Universidade de São Paulo (USP). Instituto de Química (IQ)  (Institutional affiliation for the last research proposal)
Birthplace: Israel

Graduated in Biochemsitry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He received his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces and to organize biofilm structures. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher
FAPESP selects 30 projects in call for research proposals to combat novel coronavirus 
Researchers show how opportunistic bacterium defeats competitors 
Articles published in other media outlets (21 total):
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Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 | São Paulo 
Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 
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Aplicativo permite usar peixe paulistinha para diagnosticar COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a covid 
Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a covid 
Aplicativo permite usar peixe paulistinha para diagnosticar a COVID-19 
Aplicativo permite usar peixe paulistinha para diagnosticar a covid-19 
Research grants
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (23)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications22
Citations194
Cit./Article8.8
Data from Web of Science

SOUZA, DIORGE P.; OKA, GABRIEL U.; ALVAREZ-MARTINEZ, CRISTINA E.; BISSON-FILHO, ALEXANDRE W.; DUNGER, GERMAN; HOBEIKA, LISE; CAVALCANTE, NAYARA S.; ALEGRIA, MARCOS C.; BARBOSA, LEANDRO R. S.; SALINAS, ROBERTO K.; et al. Bacterial killing via a type IV secretion system. NATURE COMMUNICATIONS, v. 6, . Web of Science Citations: 40. (05/59243-3, 09/54009-3, 11/07777-5)

BAYER-SANTOS, ETHEL; LIMA, LIDIA DOS PASSOS; CESETI, LUCAS DE MORAES; RATAGAMI, CAMILA YURI; DE SANTANA, ELIANE SILVA; DA SILVA, ALINE MARIA; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Xanthomonas citri T6SS mediates resistance to Dictyostelium predation and is regulated by an ECF sigma factor and cognate Ser/Thr kinase. ENVIRONMENTAL MICROBIOLOGY, v. 20, n. 4, SI, p. 1562-1575, . Web of Science Citations: 6. (11/07777-5, 14/25261-4, 14/19720-6, 15/25381-2, 16/08400-6)

TEIXEIRA, RAPHAEL D.; GUZZO, CRISTIANE R.; AREVALO, SANTIAGO JUSTO; ANDRADE, MAXUEL O.; ABRAHAO, JOSIELLE; DE SOUZA, ROBSON F.; FARAH, CHUCK S.. A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium Xanthomonas citri. Journal of Biological Chemistry, v. 293, n. 27, p. 10767-10781, . Web of Science Citations: 0. (11/07777-5)

CESETI, LUCAS M.; DE SANTANA, ELIANE S.; RATAGAMI, CAMILA Y.; BARREIROS, YASMIN; LIMA, LIDIA DOS PASSOS; DUNGER, GERMAN; FARAH, CHUCK S.; ALVAREZ-MARTINEZ, CRISTINA E.. The Xanthomonas citri pv. citri Type VI Secretion System is Induced During Epiphytic Colonization of Citrus. Current Microbiology, v. 76, n. 10, p. 1105-1111, . Web of Science Citations: 0. (11/22571-4, 16/08400-6, 14/19720-6, 17/02318-9, 18/01852-4, 14/25261-4, 11/07777-5)

SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA T.; NICASTRO, GIANLUCCA G.; MATSUYAMA, BRUNO Y.; MESNAGE, STEPHANE; PATEL, ANKUR; DE SOUZA, ROBSON F.; GUZZO, CRISTIANE R.; BAYER-SANTOS, ETHEL. A Family of T6SS Antibacterial Effectors Related to L,D-Transpeptidases Targets the Peptidoglycan. CELL REPORTS, v. 31, n. 12, . Web of Science Citations: 0. (18/04553-8, 17/02178-2, 16/09047-8, 19/00195-2, 17/17303-7, 18/25316-4, 16/00458-5, 18/13819-1)

DUNGER, GERMAN; GAROFALO, CECILIA G.; GOTTIG, NATALIA; GARAVAGLIA, BETIANA S.; PEREDA ROSA, MARIA C.; FARAH, CHUCK S.; ORELLANO, ELENA G.; OTTADO, JORGELINA. Analysis of three Xanthomonas axonopodis pv. citri effector proteins in pathogenicity and their interactions with host plant proteins. MOLECULAR PLANT PATHOLOGY, v. 13, n. 8, p. 865-876, . Web of Science Citations: 13. (05/59243-3)

CAPPELLETTI, PAOLA A.; DOS SANTOS, RAFAEL FREITAS; DO AMARAL, ALEXANDRE M.; HOMEM, RAFAEL AUGUSTO; SOUZA, THAIS DOS SANTOS; MACHADO, MARCOS A.; FARAH, CHUCK S.. Structure-Function Analysis of the HrpB2-HrcU Interaction in the Xanthomonas citri Type III Secretion System. PLoS One, v. 6, n. 3, p. e17614, . Web of Science Citations: 6. (05/59243-3)

OLIVEIRA, MAYCON C.; TEIXEIRA, RAPHAEL D.; ANDRADE, MAXUEL O.; PINHEIRO, GLAUCIA M. S.; RAMOS, CARLOS H. I.; FARAH, CHUCK S.. Cooperative Substrate Binding by a Diguanylate Cyclase. Journal of Molecular Biology, v. 427, n. 2, p. 415-432, . Web of Science Citations: 10. (11/07777-5)

ABIKO, LAYARA AKEMI; VITALE, PHELIPE M.; FAVARO, DENIZE C.; HAUK, PRICILA; LI, DA-WEI; YUAN, JIAQI; BRUSCHWEILER-LI, LEI; SALINAS, ROBERTO K.; BRUSCHWEILER, RAFAEL. Model for the allosteric regulation of the Na+/Ca2+ exchanger NCX. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 84, n. 5, p. 580-590, . Web of Science Citations: 3. (13/50355-0, 13/17883-2, 11/07777-5)

DUNGER, GERMAN; LLONTOP, EDGAR; GUZZO, CRISTIANE R.; FARAH, CHUCK S.. The Xanthomonas type IV pilus. Current Opinion in Microbiology, v. 30, p. 88-97, . Web of Science Citations: 10. (11/07777-5)

SOUZA, DIORGE P.; ANDRADE, MAXUEL O.; ALVAREZ-MARTINEZ, CRISTINA E.; ARANTES, GUILHERME M.; FARAH, CHUCK S.; SALINAS, ROBERTO K.. A Component of the Xanthomonadaceae Type IV Secretion System Combines a VirB7 Motif with a N0 Domain Found in Outer Membrane Transport Proteins. PLOS PATHOGENS, v. 7, n. 5, p. e1002031, . Web of Science Citations: 29. (05/59243-3)

CAPPELLETTI, PAOLA A.; DOS SANTOS, RAFAEL FREITAS; DO AMARAL, ALEXANDRE M.; HOMEM, RAFAEL AUGUSTO; SOUZA, THAIS DOS SANTOS; MACHADO, MARCOS A.; FARAH, CHUCK S.. Structure-Function Analysis of the HrpB2-HrcU Interaction in the Xanthomonas citri Type III Secretion System. PLoS One, v. 6, n. 3, p. e17614, . Web of Science Citations: 6. (05/59243-3)

SOUZA, DIORGE P.; OKA, GABRIEL U.; ALVAREZ-MARTINEZ, CRISTINA E.; BISSON-FILHO, ALEXANDRE W.; DUNGER, GERMAN; HOBEIKA, LISE; CAVALCANTE, NAYARA S.; ALEGRIA, MARCOS C.; BARBOSA, LEANDRO R. S.; SALINAS, ROBERTO K.; et al. Bacterial killing via a type IV secretion system. NATURE COMMUNICATIONS, v. 6, . Web of Science Citations: 40. (05/59243-3, 09/54009-3, 11/07777-5)

OLIVEIRA, MAYCON C.; TEIXEIRA, RAPHAEL D.; ANDRADE, MAXUEL O.; PINHEIRO, GLAUCIA M. S.; RAMOS, CARLOS H. I.; FARAH, CHUCK S.. Cooperative Substrate Binding by a Diguanylate Cyclase. Journal of Molecular Biology, v. 427, n. 2, p. 415-432, . Web of Science Citations: 10. (11/07777-5)

ABIKO, LAYARA AKEMI; VITALE, PHELIPE M.; FAVARO, DENIZE C.; HAUK, PRICILA; LI, DA-WEI; YUAN, JIAQI; BRUSCHWEILER-LI, LEI; SALINAS, ROBERTO K.; BRUSCHWEILER, RAFAEL. Model for the allosteric regulation of the Na+/Ca2+ exchanger NCX. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v. 84, n. 5, p. 580-590, . Web of Science Citations: 3. (13/50355-0, 13/17883-2, 11/07777-5)

DUNGER, GERMAN; LLONTOP, EDGAR; GUZZO, CRISTIANE R.; FARAH, CHUCK S.. The Xanthomonas type IV pilus. Current Opinion in Microbiology, v. 30, p. 88-97, . Web of Science Citations: 10. (11/07777-5)

TEIXEIRA, RAPHAEL D.; GUZZO, CRISTIANE R.; AREVALO, SANTIAGO JUSTO; ANDRADE, MAXUEL O.; ABRAHAO, JOSIELLE; DE SOUZA, ROBSON F.; FARAH, CHUCK S.. A bipartite periplasmic receptor-diguanylate cyclase pair (XAC2383-XAC2382) in the bacterium Xanthomonas citri. Journal of Biological Chemistry, v. 293, n. 27, p. 10767-10781, . Web of Science Citations: 0. (11/07777-5)

BAYER-SANTOS, ETHEL; LIMA, LIDIA DOS PASSOS; CESETI, LUCAS DE MORAES; RATAGAMI, CAMILA YURI; DE SANTANA, ELIANE SILVA; DA SILVA, ALINE MARIA; FARAH, CHUCK SHAKER; ALVAREZ-MARTINEZ, CRISTINA ELISA. Xanthomonas citri T6SS mediates resistance to Dictyostelium predation and is regulated by an ECF sigma factor and cognate Ser/Thr kinase. ENVIRONMENTAL MICROBIOLOGY, v. 20, n. 4, SI, p. 1562-1575, . Web of Science Citations: 6. (11/07777-5, 14/25261-4, 14/19720-6, 15/25381-2, 16/08400-6)

CESETI, LUCAS M.; DE SANTANA, ELIANE S.; RATAGAMI, CAMILA Y.; BARREIROS, YASMIN; LIMA, LIDIA DOS PASSOS; DUNGER, GERMAN; FARAH, CHUCK S.; ALVAREZ-MARTINEZ, CRISTINA E.. The Xanthomonas citri pv. citri Type VI Secretion System is Induced During Epiphytic Colonization of Citrus. Current Microbiology, v. 76, n. 10, p. 1105-1111, . Web of Science Citations: 0. (11/22571-4, 16/08400-6, 14/19720-6, 17/02318-9, 18/01852-4, 14/25261-4, 11/07777-5)

SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA T.; NICASTRO, GIANLUCCA G.; MATSUYAMA, BRUNO Y.; MESNAGE, STEPHANE; PATEL, ANKUR; DE SOUZA, ROBSON F.; GUZZO, CRISTIANE R.; BAYER-SANTOS, ETHEL. A Family of T6SS Antibacterial Effectors Related to L,D-Transpeptidases Targets the Peptidoglycan. CELL REPORTS, v. 31, n. 12, . Web of Science Citations: 0. (18/04553-8, 17/02178-2, 16/09047-8, 19/00195-2, 17/17303-7, 18/25316-4, 16/00458-5, 18/13819-1)

DUNGER, GERMAN; LLONTOP, EDGAR; GUZZO, CRISTIANE R.; FARAH, CHUCK S.. The Xanthomonas type IV pilus. Current Opinion in Microbiology, v. 30, p. 88-97, . Web of Science Citations: 10. (11/07777-5)

DUNGER, GERMAN; GUZZO, CRISTIANE R.; ANDRADE, MAXUEL O.; JONES, JEFFREY B.; FARAH, CHUCK S.. Xanthomonas citri subsp citri Type IV Pilus Is Required for Twitching Motility, Biofilm Development, and Adherence. MOLECULAR PLANT-MICROBE INTERACTIONS, v. 27, n. 10, p. 1132-1147, . Web of Science Citations: 22. (11/22571-4, 11/07777-5)

SGRO, GERMAN G.; COSTA, TIAGO R. D.; CENENS, WILLIAM; SOUZA, DIORGE P.; CASSAGO, ALEXANDRE; DE OLIVEIRA, LUCIANA COUTINHO; SALINAS, ROBERTO K.; PORTUGAL, V, RODRIGO; FARAH, CHUCK S.; WAKSMAN, GABRIEL. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. NATURE MICROBIOLOGY, v. 3, n. 12, p. 1429-1440, . Web of Science Citations: 11. (17/17303-7, 11/07777-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALEGRIA, Marcos Castanheira. Identificação de interações proteína-proteína envolvendo os produtos dos Loci hrp, vir e rpf de Xanthomonas axonopodis pv. citri.  215 f. Tese (Doutorado) -  Instituto de Química.  Universidade de São Paulo (USP).  São Paulo.  (98/15371-2

FERREIRA, Aurea Denise de Sousa Soller. Tropomiosinas contendo 5-hidroxitriptofano: sondas específicas para interações no filamento fino.  131 f. Tese (Doutorado) -  Instituto de Química.  Universidade de São Paulo (USP).  São Paulo.  (00/00686-0

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