CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia Bioquímica from Universidade Estadual de Maringá (2003), master's at Pharmacy from Universidade Estadual de Maringá (2006) and doctorate at Byophysics from Universidade Federal do Rio de Janeiro (2010). Has experience in Microbiology, focusing on Mycology, acting on the following subjects: atividade antifúngica, alfavaca, leveduras, candida sp and alteração ultraestrutural. (Source: Lattes Curriculum)
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Cryptococcosis is an opportunistic disease that causes meningitis. Cryptococcus spp. are considered ideal and facultative intracellular parasites, surviving in macrophages, and using them as a "Trojan horse" to penetrate the blood-brain barrier. This yeast-macrophage interaction is extremely important in the development of the disease and studies have shown that C. neoformans has develope…
Cryptococcus species are etiological agents of cryptococcosis, the cerebral form is the most frequent and severe in HIV/AIDS patients, resulting in high rates of mortality and morbidity. Although antifungal therapy for cryptococcosis is available, it is still ineffective due to the limited antifungal option, side effects, unfavorable pharmacokinetics, and the increase of isolates resistan…
Invasive fungal infections (IFIs) are considered a public health problem that result in high rates of mortality and morbidity. Among the IFIs, Candida albicans represents 50-70% of the cases, followed by Cryptococcus and Aspergillus. However, resistant and emerging species have frequently been isolated, such as Candida auris considered a superbug responsible for outbreaks in hospital on a…
Invasive fungal infections (IFIs) lead a serious health risk resulting in high rates of mortality and morbidity. Among IFIs, Candida albicans represent 50-70% of the cases, followed by Cryptococcus, Aspergillus and Pneumocystis. However, resistant and emerging fungal species have often been isolated, such as Candida auris considered a superfungus. In addition to resistance to antifungal a…
Fungi and bacteria often coexist in polymicrobial biofilms and represent a clinically relevant health problem. Among fungal species Candida albicans is the most frequent in the hospital setting and it is estimated that 27% of C. albicans bloodstream infections (BIs) are polymicrobial, wherein Stapholococcus aureus and Pseudomonas aeruginosa sre the common bacterial species isolated togeth…
The research for new antifungal agents remains a challenge for the scientific community, and synthetic substances and natural products, are the most frequently studied for the development of antifungal. Miltefosine, an alkylphospholipids analog used in the treatment of visceral leishmaniasis, has shown good antifungal activity against different species of yeast and filamentous fungi. Howe…
(Only some records are available in English at this moment)
Sporotrichosis is a subcutaneous mycosis caused by species of the genus Sporothrix, primarily transmitted through traumatic inoculation via contact with contaminated soil and plants, as well as zoonotic transmission from infected cats, whose epidemiological relevance has been increasing. The disease presents various clinical forms, with cutaneous and lymphocutaneous manifestations being t…
Fungal diseases pose an increasing challenge due to the rise in immunocompromised populations and antifungal resistance. Candida spp. and Cryptococcus spp. are particularly concerning. Candida spp., commonly found in the human microbiota, can cause candidiasis under conditions of immunological imbalance, while C. neoformans, an environmental yeast, is notorious for causing cryptococcal me…
Cryptococcus neoformans is the causative agent of pulmonary cryptococcosis and meningitis and is classified as a critical priority pathogen by the World Health Organization mainly due to its high incidence in immunosuppressed patients, resulting in high mortality rates. The treatment of this mycosis is based on antifungal drugs; however, access to these drugs is still inadequate and somet…
(Only some records are available in English at this moment)
Cryptococcosis is an opportunistic disease that causes meningitis. Cryptococcus spp. are considered ideal and facultative intracellular parasites, surviving in macrophages, and using them as a "Trojan horse" to penetrate the blood-brain barrier. This yeast-macrophage interaction is extremely important in the development of the disease and studies have shown that C. neoformans has develope…
The epidemiological scenario of infections caused by Candida spp. has worsened in recent years, largely due to the resistance acquired by these microorganisms. In recent decades, there has been an emphasis on the rise of Candida non-Candida albicans species, where Candida tropicalis is the protagonist. Also, since 2009 there is a new major health concern with the emergence of Candida auri…
Dental cavities is one of the most common diseases afflict to human beings. This illness depends on multiple factors to infect the oral environment of an individual, one of the main etiological factors being dental plaque. The dental plaque, a polymicrobial biofilm, shows cariogenic factors that originate from interactions between distinct microorganisms present in its composition. Amidst…
(Only some records are available in English at this moment)
Cryptococcus is the etiological agent of cryptococcosis, and it is estimated that 147,000 deaths and more than 190,000 cases of the disease occur annually worldwide. This high mortality is associated with the immunosuppression of patients, the virulence factors of the fungus, the limited arsenal of commercially available antifungals, and the emergence of strains resistant to therapeutic o…
Candida auris is a multidrug-resistant species that can cause serious illnesses and public healthcare outbreaks. After its discovery in 2009, extensive research has been carried out to understand its biology, resistance profile and virulence factors. Since the description of quorum sensing molecules (QSMs) in Candida spp., farnesol and tyrosol are the most studied QSMs in signaling system…
Cryptococcosis is a mycosis caused by Cryptococcus spp. with high incidence in HIV/AIDS patients leading to high mortality and morbidity rates. The current therapy of the severe clinical form, cryptococcal meningitis, is based on the combination of amphotericin B with fluconazole and flucytosine. However, factors such as high toxicity, unfavorable pharmacokinetics, high cost and unavailab…
| 3 / 3 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 11 / 10 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 30 / 29 | All research grants and scholarships |
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