CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Itália
Giuseppe Palmisano is a Full Professor at the Institute of Biomedical Sciences of the University of São Paulo (USP) and a CNPq Research Productivity Fellow (Level 1D). He holds a Masters degree in Chemistry (2004) and a PhD in Medical Biochemistry and Biology (2008) from the Università degli Studi di Bari, with a doctoral research period at the University of Southern Denmark. He completed postdoctoral training at the University of Southern Denmark, Brigham and Womens Hospital/Harvard Medical School, and other international institutions. His expertise includes Biochemistry, Proteomics, and Glycobiology, with emphasis on post-translational modifications, cancer biology, and parasitology, particularly Chagas disease. His research focuses on advanced mass spectrometrybased analytical methods, biomarker discovery, and structural characterization of proteins. He is President of the Brazilian Proteomics Society (BRProt), serves on editorial boards of international journals, and acts as a reviewer for high-impact scientific publications. He has authored more than 130 articles, with over 4,300 citations (Web of Science) and an h-index of 37. (Source: Lattes Curriculum)
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Respiratory diseases (RDs), including viral infections such as COVID-19 and chronic conditions, represent a serious public health problem, having been the third leading cause of death worldwide in 2019, with 454.6 million reported cases. Monitoring these diseases requires non-invasive methods, which are preferred by patients and represent an important area of scientific development. In th…
Chagas disease (CD) remains a debilitating neglected tropical disease and a major public health concern in endemic and non-endemic areas, affecting more than 7 million people worldwide. CD is caused by Trypanosoma cruzi, a protozoan parasite mostly transmitted by triatomine insect vectors in endemic regions of Latin America. CD progresses in three clinical phases: acute (ACD), indetermina…
This proposal aims to implement a multiuser mass spectrometry-based platform specialized in glycobiology and structural proteomics by acquiring an Orbitrap Eclipse Tribrid coupled to a Vanquish Neo liquid chromatographic system. The technical features of this equipment such as different fragmentation techniques, ion mobility separation, MSn acquisition methods, data acquisition versatilit…
A Sociedade Brasileira de Proteômica (BrProt) irá promover em Setembro de 2024 (16-19/09/2024) no campus da Universidade de São Paulo, USP, o 6º Congresso da Sociedade Brasileira de Proteômica. O evento, de natureza científica e no formato de congresso internacional presencial, contará com quatro dias de atividades educacionais, incluindo cursos abrangendo a pesquisa em proteômica, bem c…
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is an emerging human virus from the Coronaviridae family. SARS-CoV-2 is the etiological agent of novel pneumonia called COVID-19, coronavirus disease 2019. Due to the rapid increase in the number of cases that have affected countries, WHO declared COVID-19 outbreak an ongoing pandemic. As of April 1st, there are 750,8…
A Escola São Paulo de Ciência Avançada em Glicobiologia (SPSAS-GLYC) reunirá pesquisadores internacionais e nacionais que são referência na área de glicobiologia. São pesquisadores pioneiros que têm produzido resultados considerados na fronteira do conhecimento, abordando diferentes aspectos de glicoconjugados para elucidar sistemas biológicos complexos.Os temas a serem abordados, que for…
(Only some records are available in English at this moment)
In recent years, the importance of studying respiratory diseases (RDs) has become increasingly evident, especially in light of viral infections responsible for pandemics, such as Covid-19. However, not only viral RDs are of concern: in 2019, RDs were the third leading cause of death worldwide, with 454.6 million reported cases. A large proportion of these diseases are chronic in nature, r…
Biologics have become a rising treatment for many diseases, such as cancer, hormone repositioning, vaccines, and many others. The increased use of biologics raised attention to drug spending in this treatment niche. Thus, as patent exclusivities for a biologic expire, biosimilars are produced and gain room as a treatment alternative. However, subtle differences in the structure do not mak…
Type 2 diabetes mellitus (T2DM), the most prevalent form of diabetes, affects millions globally and is strongly associated with cognitive decline, dementia, and neurovascular complications. Chronic hyperglycaemia in T2DM damages the blood-brain barrier and impairs microvascular function, leading to brain atrophy and cognitive deficits. While studies have linked these effects to altered pr…
(Only some records are available in English at this moment)
A doença de Chagas, causada pelo parasita protozoário T.cruzi, é uma doença negligenciada, que pode levar à cardiomiopatia, além de complicações neurológicas e "megaviscera". Apesar dos grandes esforços para controlar a transmissão de T.cruzi e introduzir novas opções terapêuticas, ainda não existem marcadores diagnósticos sensíveis e específicos para resposta ao tratamento e progressão d…
A bolsa será usada para apoiar um profissional técnico que aprenderá e realizará experimentos de rotina em proteômica baseados em espectrometria de massas. Em particular, o técnico ajudará os outros pesquisadores envolvidos no projeto JP2 a realizar a preparação de amostras proteômicas. O treinamento envolverá: Extração de proteínas de biofluídos; Digestão de proteínas e limpeza de amostr…
Trypanosoma cruzi is the etiologic agent of Chagas disease, also known as American trypanosomiasis, a potentially fatal parasitic infection that affects between 6 and 8 million individuals worldwide. Although Chagas disease is mainly found in endemic regions of Latin American countries, this infection is recognized as a potentially serious emerging global health problem. During infection …
(Only some records are available in English at this moment)
Post-translational modifications (PTMs) modulate proteins' structure, function, subcellular localization, and protein-protein interaction, playing a fundamental role in maintaining cellular homeostasis and are regulated during the pathogenesis of several diseases. N and O-linked glycan sialylation, phosphorylation and cysteine oxidation comprise mammalian cells' most studied PTMs. The rec…
Amyotrophic lateral sclerosis (ALS) occurs due to the degeneration of both upper and lower motor neurons in the cerebral cortex and spinal cord. ALS has a prevalence of 5 individuals in 100,000 each year worldwide, most being classified as sporadic, therefore, of unknown cause, making it challenging to adopt palliative strategies. The causes of ALS are only partially understood; however, …
(Only some records are available in English at this moment)