CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Itália
Graduated in chemistry from Univeristy of Bari, Italy and with a doctoral degree in medical biochemistry from the University Hospital of Bari, Italy. Posdoc at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. He is currently professor at the Department of Parasitology, University of São Paulo. Has experience in protein chemistry with special focus on analytical methods applied to protein on a large scale. His areas of expertise are: proteomics, post-translational modifications, cell signalling, mass spectrometry and plant proteomics. (Source: Lattes Curriculum)
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Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is an emerging human virus from the Coronaviridae family. SARS-CoV-2 is the etiological agent of novel pneumonia called COVID-19, coronavirus disease 2019. Due to the rapid increase in the number of cases that have affected countries, WHO declared COVID-19 outbreak an ongoing pandemic. As of April 1st, there are 750,8…
Chagas Disease, caused by the protozoan parasite T. cruzi, is a neglected disease, which can lead to Cardiomyopathy, neurological complications and megaviscera. Over 100 years after its description, this disease affects 8 million people and most of them do not know that they are infected. Although endemic in the South America, it has been recognized a worldwide public health problem due t…
We aim at building an analytical platform for glycan identification and quantification. The analysis of mono, oligo and polysaccharides will offer the possibility of studying the modulation of the cellular, tissue and biofluid glycome in different biological systems. Differential glycan expression has been associated to several diseases from cancer, infectious diseases and others. In part…
Chagas disease is a neglected disease caused by the unicellular protozoan Trypanosoma cruzi parasite, endemic in 21 Latin American countries where 70 million people are at risk of infection and 6-7 million people are infected. Benznidazole (BNZ) is the first-line drug for the treatment of Chagas disease (CD). Although it is highly effective in the acute phase, moderate efficacy and dose-…
In this study we will focus our interest on small particles secreted by normal and tumour cells called exosomes. Cancer-produced exosomes condition and prepare organs to metastatic dissemination. In other words, exosomes are akin to messengers of - death sent by tumour cells to facilitate cancer growth and survival. It would be very important to identify further proteins in tumour exosome…
(Only some records are available in English at this moment)
The survival of the parasite Trypanosoma cruzi during the cell cycle and establishment of the infection depends on specific processes that guarantee its adaptation in the most varied conditions. In this context, post-translational modifications, such as glycosylation, have been widely studied, mainly because they contain proteins that can be used as biomarkers for Chagas Disease. In T. br…
The Endoplasmic Reticulum (ER) is a dynamic and multifunctional organelle, in which several essential cellular functions are developed including protein folding, protein glycosylation, redox balance, calcium storage and lipid and carbohydrate metabolism. ER homeostasis can be compromised by different biotic and abiotic factors and in order to re-establish homeostasis, the Unfolded Protein…
Protein O-linked glycosylation is a post-translational modification (PTM) of proteins at serine or threonine hydroxyl functional groups. This PTM plays important roles including mammalian cell adhesion, functional determinants for antibody recognition, regulation of protein stability and activity, targeting of glycoproteins, and in host-parasite interaction where, for example, Trypanosoma…
(Only some records are available in English at this moment)
Trypanosoma cruzi, the etiological agent of Chagas Disease or American trypanosomiasis, is highly heterogenetic, with multiple genotypes and phenotypes currently recognized. At present, T. cruzi is classified into six Discrete Typing Units (DTUs), TcI-TcVI, infecting humans along with the TcVII, which infects bats. Each DTU/genetic subdivision has a distinct biological and host associatio…
(Only some records are available in English at this moment)
Prostate cancer (PCa) is the second most common cancer in men worldwide. Gleason score classification is the most important predictor of PCa outcomes and is influential in determining patient treatment options. However, tumor heterogeneity, biopsy-sampling error, and variations in biopsy interpretation are still key challenges for accurate prognostication, leading to significant overtreat…
| 3 / 3 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 7 / 5 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 22 / 19 | All research grants and scholarships |
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