CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Itália
Graduated in chemistry from Univeristy of Bari, Italy and with a doctoral degree in medical biochemistry from the University Hospital of Bari, Italy. Posdoc at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. He is currently professor at the Department of Parasitology, University of São Paulo. Has experience in protein chemistry with special focus on analytical methods applied to protein on a large scale. His areas of expertise are: proteomics, post-translational modifications, cell signalling, mass spectrometry and plant proteomics. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Chagas disease (CD) remains a debilitating neglected tropical disease and a major public health concern in endemic and non-endemic areas, affecting more than 7 million people worldwide. CD is caused by Trypanosoma cruzi, a protozoan parasite mostly transmitted by triatomine insect vectors in endemic regions of Latin America. CD progresses in three clinical phases: acute (ACD), indetermina…
This proposal aims to implement a multiuser mass spectrometry-based platform specialized in glycobiology and structural proteomics by acquiring an Orbitrap Eclipse Tribrid coupled to a Vanquish Neo liquid chromatographic system. The technical features of this equipment such as different fragmentation techniques, ion mobility separation, MSn acquisition methods, data acquisition versatilit…
Chagas Disease, caused by the protozoan parasite T. cruzi, is a neglected disease, which can lead to Cardiomyopathy, neurological complications and megaviscera. Over 100 years after its description, this disease affects 8 million people and most of them do not know that they are infected. Although endemic in the South America, it has been recognized a worldwide public health problem due t…
(Only some records are available in English at this moment)
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is an emerging human virus from the Coronaviridae family. SARS-CoV-2 is the etiological agent of novel pneumonia called COVID-19, coronavirus disease 2019. Due to the rapid increase in the number of cases that have affected countries, WHO declared COVID-19 outbreak an ongoing pandemic. As of April 1st, there are 750,8…
(Only some records are available in English at this moment)
Type 2 diabetes mellitus (T2DM), the most prevalent form of diabetes, affects millions globally and is strongly associated with cognitive decline, dementia, and neurovascular complications. Chronic hyperglycaemia in T2DM damages the blood-brain barrier and impairs microvascular function, leading to brain atrophy and cognitive deficits. While studies have linked these effects to altered pr…
Chagas disease (CD) remains a debilitating neglected tropical disease and a major public health concern in endemic and non-endemic areas, affecting more than 7 million people worldwide. CD is caused by Trypanosoma cruzi, a protozoan parasite mostly transmitted by triatomine insect vectors in endemic regions of Latin America. CD progresses in three clinical phases: acute (ACD), indetermina…
(Only some records are available in English at this moment)
Trypanosoma cruzi is the etiologic agent of Chagas disease, also known as American trypanosomiasis, a potentially fatal parasitic infection that affects between 6 and 8 million individuals worldwide. Although Chagas disease is mainly found in endemic regions of Latin American countries, this infection is recognized as a potentially serious emerging global health problem. During infection …
The survival of the parasite Trypanosoma cruzi during the cell cycle and establishment of the infection depends on specific processes that guarantee its adaptation in the most varied conditions. In this context, post-translational modifications, such as glycosylation, have been widely studied, mainly because they contain proteins that can be used as biomarkers for Chagas Disease. In T. br…
(Only some records are available in English at this moment)
Post-translational modifications (PTMs) modulate proteins' structure, function, subcellular localization, and protein-protein interaction, playing a fundamental role in maintaining cellular homeostasis and are regulated during the pathogenesis of several diseases. N and O-linked glycan sialylation, phosphorylation and cysteine oxidation comprise mammalian cells' most studied PTMs. The rec…
Amyotrophic lateral sclerosis (ALS) occurs due to the degeneration of both upper and lower motor neurons in the cerebral cortex and spinal cord. ALS has a prevalence of 5 individuals in 100,000 each year worldwide, most being classified as sporadic, therefore, of unknown cause, making it challenging to adopt palliative strategies. The causes of ALS are only partially understood; however, …
Prostate cancer (PCa) is the second most common cancer in men worldwide. Gleason score classification is the most important predictor of PCa outcomes and is influential in determining patient treatment options. However, tumor heterogeneity, biopsy-sampling error, and variations in biopsy interpretation are still key challenges for accurate prognostication, leading to significant overtreat…
| 4 / 4 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 14 / 12 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 33 / 30 | All research grants and scholarships |
| Associated processes | |