CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a bachelor's degree in biological sciences - emphasis on biotechnology from the Universidade do Vale do Itajaí (2005). Received his PhD from the Department of Physiology and Biophysics, Institute of Biomedical Sciences of the University of São Paulo, where he was a FAPESP postdoctoral fellow investigating the effects of omega-3 fatty acids on energy metabolism (2011). Worked at the Technical University of Munich (TUM) investigating postprandial metabolic adaptations, using mass spectrometry to identify markers of phenotypic flexibility. At the French National Institute for Agricultural Research (INRA) he developed research in search of new metabolites of dietary monoterpenoids using in silico tools to predict the metabolism of xenobiotics and high resolution mass spectrometry. He is a professor in the Department of Food and Experimental Nutrition of the Faculty of Pharmaceutical Sciences of the University of São Paulo, leading the Nutritional Physiology Laboratory. He is the editor-in-chief of the journal Genes Nutrition (ISSN: 1865-3499). (Source: Lattes Curriculum)
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This proposal outlines a collaborative research initiative between the University of São Paulo (USP), the Technical University of Braunschweig (TU Braunschweig), and the European Molecular Biology Laboratories (EMBL), focusing on the role of bile acids as integrators of metabolism and immune function, and their influence on the composition of the intestinal microbiota. Building on a well-…
Physiological processes involved in food digestion and metabolic adaptations to the newly available energy substrates are observed in the postprandial period. During this period, a transient inflammatory response is observed, characterized by an increase in the number of circulating leukocytes, changes in their gene expression and an increase in plasma levels of inflammatory cytokines. Th…
Bile acids (BA) are amphipathic compounds produced by the liver that participate in the emulsification of dietary lipids. Due to the nature of the enterohepatic circulation and the partial escape of these molecules from first-pass absorption by the liver, plasma concentration of BA increases up to 20-fold after the ingestion of a meal, similarly to what occurs with certain hormones. In th…
We propose the execution of a clinical study conducted remotely, with minimally invasive, low-cost blood sampling techniques, whose execution is compatible with the limitations imposed by the COVID-19 pandemic. This study will serve as proof of feasibility of a remote clinical trial and will have as its central objective the investigation of the effects of D-limonene on postprandial inter…
The health effects of flavonoids and other bioactive compounds found in oranges have been studied for a long time. On the other hand, bioactive phytochemicals found in citrus such as d-limonene, have not yet been properly studied. Due to its antimicrobial activity, we believe that d-limonene can modulate the composition of intestinal microbiota, responsible for metabolizing bile acids. Bi…
Changes in dietary patterns, influenced by socioeconomic factors such as urbanization and population aging, and changes in lifestyle such as increased sedentary lifestyle and availability of ultra-processed foods, have contributed to the increase in chronic non-communicable diseases. Balanced diets, such as the Mediterranean diet, offer benefits for metabolic health, while the Western die…
The nutrients that make up a meal and intrinsic factors of each individual are responsible for determining postprandial responses, which present high interindividual variability. Among the changes observed in the postprandial period, there is a transient inflammatory response that is related to the development of chronic diseases. The increase in the circulating concentration of bile acid…
(Only some records are available in English at this moment)
This project seeks to characterize an animal model to study postprandial metabolic changes and investigate possible associations between the increase in plasmatic concentration of bile acids after ingestion of a meal with the other metabolic and inflammatory changes observed in this period. The main functions of the undergraduate student will be: a) Assist in the maintenance of animals in…
Endocannabinoids are lipids derived from polyunsaturated fatty acids fromlong chains that combined with their synthesis and degradation enzymes and receptorsCB1 and CB2, comprise the endocannabinoid system, responsible for triggering severalphysiological effects. This study aims to clarify the relationship between menopause and changes inplasma concentration of endogenous cannabinoids dur…
(Only some records are available in English at this moment)
Lipoproteins are macromolecular complexes that mediate the transport of lipids through the bloodstream, playing a pivotal role in lipid metabolism. Postprandial lipid metabolism involves coordinated secretion and clearance of lipoproteins and their metabolizing enzymes. Bile acids (BA) are metabolites produced by the host and its intestinal microbiota. Due to the activation of nuclear and…
In the postprandial period, an array of physiological adaptations tonutrient intake take place to adjust metabolism for the newly available energysubstrates and other components of the meal. During this phase, fluctuations incirculating levels of signaling messengers and metabolites, including lipoproteinsand bile acids (BA), play a key role in energy homeostasis and immunemodulation. Whi…
After the ingestion of a meal, changes in plasma levels of nutrients, endogenous metabolites and signaling molecules trigger changes in several physiological processes, affecting energy metabolism and inducing a transient inflammatory response. The increase in plasma levels of bile acids (BA) is one of the most remarkable changes in plasma metabolome in the postprandial period, although i…
Omega-3 polyunsaturated fatty acids (n-3 PUFA) are associated with the prevention of insulin resistance. These molecules increase peroxisomal ²-oxidation of fatty acids (FA) and stimulate peroxisome proliferation in the liver through the activation of peroxisome proliferator activated receptors (PPAR). This project is based on the hypothesis that other than increasing peroxisomal FA ²-oxi…
| 3 / 3 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 12 / 12 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 32 / 32 | All research grants and scholarships |
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