Graduated in Medicine from the Faculty of Medicine of the University of São Paulo (1984) and doctorate in Physiology and Biophysics from the Institute of Biomedical Sciences at USP (1995). He is currently an associate professor at the Faculty of Medicine of the University of São Paulo. He works at FMUSP, Hospital das Clínicas, FMUSP and Hospital Universitário, FMUSP. He has experience in the field of Medicine, with an emphasis on Clinical Emergencies. The central area of research is sepsis involving the following sub-themes, divided into two major sectors: 1- Septic shock, inflammation, tissue damage, multiple organ failure, metabolic changes, production of free radicals and activation of PARP; 2- in another line, there are studies on LPS tolerance, immunological regulation, gene expression and lymphocyte apoptosis / necrosis. (Source: Lattes Curriculum)
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Spontaneous hypothermia in septic patients is frequently fought off with active rewarming, but this practice is not evidence-based. Moreover, the need for rewarming patients from hypothermia in this case has been recently questioned by a study showing that septic hypothermia is a transient, self-limiting and non-terminal response. Here, we propose a prospective, interventional trial to as…
Sepsis, SIRS and septic shock are responsible for 30-45% of death in ICU. The treatment is based only in hemodynamic support and source control. The cytokines induces the release of many others inflammatory mediators, as for instance reactive oxygen species, and nitric oxide. Toll-like (TLR) inhibitors, antinflammatory cytokines and changes in TLR signaling are the mechanism that control …
Sepsis, SIRS and septic shock are responsible for 30-45% of death in ICU. The treatment is based only in hemodynamic support and source control. SIRS causes tissue and organ damage even in organs not involved in the infectious process, vasodilatation, myocardic depression, and tissular hupoperfusion, disseminated intravascular coagulation state known as severe sepsis and septic shock. The…
(Only some records are available in English at this moment)
Mesenchymal stem cells (MSCs) have great capacity for proliferation, self-renewal and differentiation into different, more specialized cell lines. This population of adult stem cells is easily obtained and, due to their immunomodulatory and antimicrobial characteristics, they have been strong candidates as a new therapeutic tool to treat sepsis. In this context, preliminary studies in our…
Sepsis is known as a systemic inflammatory syndrome in response to an infection. It is a serious illness which can cause multiple organ failure and is currently the leading cause of death in patients admitted to Intensive Care Unit. Infection by gram-negative bacteria represents most of the recorded cases of Sepsis. The lipopolysaccharide (LPS) of the bacterial outer membrane component in…
Stem Cells (SCs) are cells with high proliferation capacity, self-renewal and ability to differentiate into more specialized cell lines. Adult CTs, such as Mesenchymal Stem Cells (MSCs) are of great interest for regenerative medicine, mainly in replacement tissues and transplants, such as bone marrow. MSCs are easy to obtain and have high proliferative capacity in vitro. These cells offer…
(Only some records are available in English at this moment)
Cancer development is a complex process involving diverse tissue types of distinct developmental origins, cell-cell interactions, and a myriad of signaling pathways. Cancer can evolve from a combination of epigenetic and genetic abnormalities resulting in dysregulated gene expression and function. Cells in nearly any part of the body can become cancer. Acute myeloid leukemia (AML) is one …
Multiple studies implicated H2S in many physiological processes, as well as in various forms of neurological, cardiovascular, metabolic diseases, and in critical illness. The biological character of H2S in health and disease is determined by a complex interplay between three factors: (1) expression/activity of H2S-producing enzymes; (2) redox status and reactive oxygen/nitrogen species pr…
| 8 / 6 | Completed research grants |
| 16 / 12 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 27 / 20 | All research grants and scholarships |
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CV Lattes
ORCID