CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba (FOP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr Vargas is a dental graduate of the UNESP-Araraquara-Brazil and obtained a Master of Science and PhD titles from the UNICAMP-Piracicaba-Brazil in Oral Pathology. He was chairman of the post-graduate course of Oral Pathology-UNICAMP for 4 years (2000-2004).He was also president of the II International Congress of Dentistry of the UNICAMP, which was held in Piracicaba, Brazil in 2004. He was Honorary Senior Lecturer of the Department of Oral Pathology of the University of Sheffield-UK (2005-2007). He has been teaching OralPathology in the School of Dentistry of Piracicaba-UNICAMP. He was vice-chair of the Department of Oral Diagnosis-UNICAMP and Latin America and Caribbean Councillor of the International Association of Oral Pathologists (IAOP) (2008-2012). He was local president of the XVI International Congress of Oral Pathology and Medicine (IAOP-SOBEP Joint Meeting), which was held in São Pedro, Brazil in 2012. He has authored or co-authored 411papers (385 indexed in PUBMED) on Oral Pathology and Medicine. He has been acting as reviewer of numerous international periodicals as Oral Oncology, Oral Diseases and Medicinal Oral Patologia Oral Cirurgia Oral. He belongs to the editorial board of 4 international journals: 1- Oral Oncology; 2- Oral Surg Oral Med Oral Path Oral Radiol; 3- Medicina Oral Patologia Oral Cirurgia Oral; 4- Head and Neck Pathology. He was granted with FRCPath (The Royal College of Pathologists-UK) in January-2013 and Extraordinary Professor at University of Pretoria-South Africa (2014 to date). Director of International Relations - UNICAMP (2017). President of the Brazilian Society of Oral Medicine and Oral Pathology (2023 - 2025) and President of International Association of Oral Pathologists (IAOP) (2024-2026). Honoray International Membership (British Society Oral Maxillofacial Pathology). WHO author in the blue book "WHO Classification of Tumours, 5th edition: Head and Neck Tumours (2024). He authored or co-authores more than 415 scientific papers. He is a diagnostic pathologist of oral lesions in Piracicaba and his main research fields are molecular pathology of salivary gland lesions, cysts and odontogenic tumours, oral cancer, FNAC, and salivary gland involvement in AIDS patients. (Source: Lattes Curriculum)
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Head and Neck Squamous Cell Carcinomas (HNSCCs) represent one of the 6 most common Cancers worldwide. Among different therapeutic approaches, the use of chemotherapy alone or in association with radiotherapy or surgery has proven beneficial to the overall patient survival. Nonetheless, when compared to other Cancers like Leukemia and Hodgkin's disease, the benefits of chemotherapy for Hea…
Backgroud: Salivary gland tumors (SGT) account for 3% to 10% of all head and neck neoplasms and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human cancers, they remain to be investigated in SGT. Therefore, the objective of this study is to analyze the clinical significance of the express…
Salivary gland tumors is a highly heterogeneous group that accounts for 3 to 6% of all head and neck neoplasias, with an incidence ranging from 0.4 to 13.5 cases/100,000 individuals. Due to their clinicopathologic variability, the diagnosis of these tumors becomes a real challenge even for experient pathologists, which contributes for the discrete knowledgment concerning biologic factors …
(Only some records are available in English at this moment)
It is well established in the literature that tumor stem cells (TSCs) play a significant role in the treatment failure of head and neck cancers, as they have shown to be less sensitive to conventional therapies and remain viable afterchemotherapy and radiotherapy, allowing for tumor recurrence and metastasis. Recent findings have demonstrated that the use of Emetine and SAHA(Suberoylanili…
Early diagnosis of oral squamous cell carcinoma is a desired goal to reduce mortality rates due to this prevalent pathology. To achieve this purpose, identification of lesions in incipient stages (OSCCi), such as carcinoma in situ and microinvasive squamous cell carcinoma is essential since they are the two most initial presentations of OSSC, and their clinical and histopathological featu…
Head and Neck Squamous Cell Carcinomas (HNSCCs) are the sixth most common Cancer worldwide, with the mouth and oropharynx as the most affected sites. The treatment is complex and involves, in most cases, the use of multiple therapeutic modalities in combination. Chemotherapy, with or without surgery or radiotherapy, has been widely used in advanced cases of HNSCC. However, when compared t…
The research project selected refers to the thematic project entitled: "Disruption of tumorresistance through therapy directed at tumor stem cell depletion in head and necksquamous cell carcinomas". This project was chosen for this call considering the resultsalready achieved by the thematic under development, the dedication of the team involvedin the project and especially due to the imp…
Squamous cell carcinoma (SCC) is the most common type of oral cancer and has an increasing incidence in many countries. Despite the advances in the understanding of the disease, the survival rate has not shown significant improvement in recent decades and there are still no reliable prognostic markers that can indicate the outcome and guide a better response to therapy. Tumor-related fact…
Small, round and blue cell neoplasms are tumors that represent a challenge to pathologists, as they mainly share similar morphological, immunophenotypic and molecular characteristics. With the advent of more advanced computational technologies, the use of artificial intelligence techniques through digital systems and the development of algorithms for image analysis have been studied to im…
(Only some records are available in English at this moment)
The aim of this study is to develop and assess the performance of Deep Learning models for multi-class automatic classification and decision-making assistance of common oral lesions using clinical images, including oral potentially malignant disorders and oral squamous cell carcinoma, and to explore Explainable Artificial Intelligence (XAI) methods to assess interpretability. Clinical ima…
Lymphomas are hematopoietic neoplasms that present a diagnostic challenge for pathologists due to their distinct morphological, immunophenotypic, and molecular features. With the advancement of computational technologies, the utilization of artificial intelligence techniques through digital systems and the development of algorithms for image analysis have been studied to enhance diagnosti…
Head and neck cancer is a public health problem in many parts of the world, and squamous cell carcinomas account for approximately 90% of these malignant tumors. Despite advances in treatment, head and neck squamous cell carcinoma (HNSCC) survival rates remain unsatisfactory and is mainly associated with advanced-stage diagnosis and drug resistance. Because of the severe morbidity and mor…
Mucoepidermoid carcinoma (MEC) is the most common malignancy from the salivary glands. The management of MEC follows similar protocols used in other malignancies from the salivary glands. Our previous results presented new therapies that target cancer stem cells (CSC) from MEC. However, new approaches are needed due to radiotherapy toxicities and resistance against the current chemotherap…
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour. The CRTC1-MAML2 translocation has been identified in approximately 50% of cases and is associated with improved survival rates, although some authors have questioned its prognostic value. The mechanism of action of the CRTC1-MAML2 translocation is complex and may influence several important pathways in tumo…
(Only some records are available in English at this moment)
| 8 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 24 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 42 / 36 | All research grants and scholarships |
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