CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated as Bachelor of Biological Science at the Universidade Federal de São Carlos in 1996. Obtained a master degree in Human Genetics in 1999 at the Georg-August Universität Göttingen-Germany and phD in Human Biology in 2006 at the Ludwig Maximilian Universität München-Germany, where she also spent a year as a post-doc fellow in the Clinical Cooperative Group Leukemia (CCG-Leukemia). She has experience in Tumor Biology, her research has been mainly focoused in the molecular mechanisms involved in tumorigenesis. She is currently a researcher at the Hematology and Hemotherapy Center of the State University of Campinas (Unicamp). Additionally, since november 2012 works as a representative of the Ludwig-Maximilians-Universität international office in Brazil supporting university's international relations. (Source: Lattes Curriculum)
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Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults and the most aggressive subtype of glioma. Patients with GBM have a median survival of 15 months and a 5-year survival rate of 10%. Treatment consists of surgical resection, followed by radiation therapy with ionizing radiation (IR) and chemotherapy with temozolomide (TMZ). The therapy is based on inducing DN…
Melanoma is the type of cancer that originates from the malignant transformation of the skin's pigment cells, melanocytes, and is characterized by a high capacity to metastasize during the early stages of tumor development. Most melanomas present activating mutations in genes involved in cell growth signaling, such as the MAPK and PI3K pathways. Furthermore, somatic mutations in spliceoso…
PIMREG is a proliferation marker that plays a role in cell cycle control and tumorigenesis. Its expression is induced by mitogens, varies according to the phases of the cell cycle and is directly related to the proliferative state of both tumor and normal cells. Recent studies showed elevated levels of its transcripts in tumor samples compared to the normal adjacent tissue of patients wit…
KIS (UHMK1) is a nuclear serine/threonine kinase that possesses a U2AF homology motif (UHM) and phosphorylates and regulates the activity of the splicing factors SF1 and SF3b1. Upon interaction, KIS phosphorylates SF1, which in turn enhances its binding to U2AF65 and the 3' splice site, an event known to take place during the early steps of spliceosome assembly. Somatic mutations in sever…
Glioblastoma (GBM) is the most common central nervous system tumour in adults, often associated with genetic heritance and irradiation exposure. It is classified as grade 4 for malignancy because of its survival levels after five years in only 6% of the patients. The protein PIMREG (PICALM interacting mitotic regulator) - an important biomarker for cell proliferation and tumour progressio…
Melanoma is the most aggressive type of skin cancer, specially for its high metastatic potential. U2AF homology motif protein kinase 1 (UHMK1) takes center stage as a key orchestrator of splicing factors, having influence over protein translation. Examination of The Cancer Genome Atlas (TCGA) data showed that tumor samples from cutaneous melanoma patients exhibit higher UHMK1 expression c…
PIMREG (PICALM interacting mitotic regulator) is a nuclear protein enriched at the nucleolus. It is a substrate of the anaphase promoter/cyclosome complex (APC/C), which controls the transition from metaphase to anaphase. We have recently shown that PIMREG is upregulated in several types of cancer, with higher expression in glioblastoma (GBM). Moreover, our data suggests that PIMREG may p…
PIMREG (PICALM interacting mitotic regulator) is a nuclear protein enriched in the nucleolus and highly expressed in the thymus and in the spleen. Besides that, it is a substrate of the anaphase/cyclosome promoter complex (APC/C), playing a role as a mitotic regulator. Also, PIMREG function is related to carcinogenesis, since its expression is increased in several types of cancer, especia…
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PIMREG, a protein associated with cellular proliferation, is highly expressed in many types of cancer, in particular glioblastoma (GBM). This type of cancer, which affects the central nervous system, is associated with poor prognostic in patients and reoccurs in most cases after surgical resection and chemotherapy, showing resistance, possibly through activation of DNA damage response (DD…
Splicing Factor 1 is located on chromosome 11q13. The protein contains an ULM motif, a coiled-coil and KH-QUA2 domains, followed by a zinc knuckle and a proline rich region. SF1 recognizes the branch point sequence within the intron, interacts with the U2AF subunits and signals the first steps of spliceosome assembly. In the alternative splicing, SF1 selectively regulates a subset of intr…