Leticia Fröhlich Archangelo
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated as Bachelor of Biological Science at the Universidade Federal de São Carlos in 1996. Obtained a master degree in Human Genetics in 1999 at the Georg-August Universität Göttingen-Germany and phD in Human Biology in 2006 at the Ludwig Maximilian Universität München-Germany, where she also spent a year as a post-doc fellow in the Clinical Cooperative Group Leukemia (CCG-Leukemia). She has experience in Tumor Biology, her research has been mainly focoused in the molecular mechanisms involved in tumorigenesis. She is currently a researcher at the Hematology and Hemotherapy Center of the State University of Campinas (Unicamp). Additionally, since november 2012 works as a representative of the Ludwig-Maximilians-Universität international office in Brazil supporting university's international relations. (Source: Lattes Curriculum)
- Defining the functional role of the splicing factor regulator (KIS) during leukemogenesis using a murine bone marrow transplantion model, AP.JP
Abstract
KIS (UHMK1) is a nuclear serine/threonine kinase that possesses a U2AF homology motif (UHM) and phosphorylates and regulates the activity of the splicing factors SF1 and SF3b1. Upon interaction, KIS phosphorylates SF1, which in turn enhances its binding to U2AF65 and the 3' splice site, an event known to take place during the early steps of spliceosome assembly. Somatic mutations in sev...
- SF1 mutations spectrum in cancer and implications on its subcellular localization and splicing function, BP.IC
Abstract
The SF1 protein recognizes the introns 3' regions during early stages of the spliceosome formation, but it is not required to constitutive splicing of all pre-mRNA in cells. Thus, SF1 acts as an alternative splicing factor on a cellular subset of pre-mRNAs. Besides acting on splicing, other functions have been described for SF1 in RNA nuclear retention and transcriptional repression. In...
- Functional characterization of KIS and its role in leukemogenesis, BP.DD
Abstract
KIS is a serine / threonine kinase that couples both functions of controlling the cell cycle and activity of splicing factors. Through its UHM domain, KIS interacts with splicing factors SF1 and SF3b1 and through its kinase activity phosphorylates these factors. Thus it is proposed that KIS function is related to RNA splicing control. The analysis of the genome and exome of patients wit...
- Consequence of G372v and T454M mutations in SF1 functionality, BP.IC
Abstract
The SF1 protein recognizes the 3' regions of the introns during the initial stages in the formation of the spliceosome, but it is not necessary for the constitutive splicing of all premRNA in the cells. Thus, SF1 acts as an alternative splicing factor on a sub-set of cellular premRNAs. Somatic mutations in several genes related to the splicing process, including SF1 and SF3b, have recen...
- Investigation of cooperative oncogenes in IL7R-mediated acute lymphoblastic leukemia emergence, BP.MS
Abstract
Among different types of hematological cancer, acute lymphoblastic leukemia (ALL) is characterized by lymphoid progenitor cells bearing inherited genetic mutations and/or accumulated epigenetic alterations, affecting both T- and B-cell lineages, mainly during childhood. Genomic profiling has improved our understanding of the several pathways altered in ALL cells, and brought the cure ra...
- Functional consequence of the splicing factor SF1 inhibition in leukemic cell line, BP.MS
Abstract
The splicing factor SF1 recognizes the 3 'regions of the introns during the early stages of spliceosome formation, but is not required for general splicing of all pre-mRNA in eukaryotic cells. Thus, SF1 targets a subset of pre-mRNAs, acting as an alternative splicing factor. Besides SF1 function in splicing, its role in tumorigenesis has also been described. SF1 can act either as an onc...
(Only some records are available in English at this moment)
- Determination of global RNA splicing in SF1 overexpressed cells by RNA-seq, BE.EP.IC
Abstract
Splicing Factor 1 is located on chromosome 11q13. The protein contains an ULM motif, a coiled-coil and KH-QUA2 domains, followed by a zinc knuckle and a proline rich region. SF1 recognizes the branch point sequence within the intron, interacts with the U2AF subunits and signals the first steps of spliceosome assembly. In the alternative splicing, SF1 selectively regulates a subset of in...
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 11 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 5 |
| Citations | 31 |
| Cit./Article | 6.2 |
| Data from Web of Science | |
ARCHANGELO, LETICIA FROEHLICH; GREIF, PHILIPP A.; MAUCUER, ALEXANDRE; MANCEAU, VALERIE; KONERU, NARESH; BIGARELLA, CAROLINA L.; NIEMANN, FERNANDA; DOS SANTOS, MARCOS TADEU; KOBARG, JOERG; BOHLANDER, STEFAN K.; et al. The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS). BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1833, n. 5, p. 1269-1279, MAY 2013. Web of Science Citations: 8.
BARBUTTI, ISABELLA; XAVIER-FERRUCIO, JULIANA M.; MACHADO-NETO, JOAO AGOSTINHO; RICON, LAUREMILIA; TRAINA, FABIOLA; BOHLANDER, STEFAN K.; OLALLA SAAD, SARA TERESINHA; ARCHANGELO, LETICIA FROHLICH. CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells. ONCOTARGET, v. 7, n. 42, p. 68385-68396, OCT 18 2016. Web of Science Citations: 4.
BIGARELLA, CAROLINA L.; VIEIRA FERRO, KARLA P.; BARCELLOS, KARIN S. A.; MARTINS-DE-SOUZA, DANIEL; TRAINA, FABIOLA; NOVELLO, JOSE C.; OLALLA SAAD, SARA T.; ARCHANGELO, LETICIA FROEHLICH. Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. FEBS Letters, v. 586, n. 19, p. 3522-3528, SEP 21 2012. Web of Science Citations: 6.
BARBUTTI, ISABELLA; MACHADO-NETO, JOAO AGOSTINHO; ARFELLI, VANESSA CRISTINA; CAMPOS, PAULA DE MELO; TRAINA, FABIOLA; OLALLA SAAD, SARA TERESINHA; ARCHANGELO, LETICIA FROHLICH. The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1864, n. 3, p. 959-966, MAR 2018. Web of Science Citations: 1.
ARCHANGELO, LETICIA FROEHLICH; GREIF, PHILIPP A.; HOELZEL, MICHAEL; HARASIM, THOMAS; KREMMER, ELISABETH; PRZEMECK, GERHARD K. H.; EICK, DIRK; DESHPANDE, ANIRUDDHA JAYANT; BUSKE, CHRISTIAN; DE ANGELIS, MARTIN HRABE; et al. The CALM and CALM/AF10 interactor CATS is a marker for proliferation. MOLECULAR ONCOLOGY, v. 2, n. 4, p. 356-367, DEC 2008. Web of Science Citations: 12.
(References retrieved automatically from State of São Paulo Research Institutions)
ARCHANGELO, Leticia Fröhlich. Investigação da participação da quinase reguladora de fatores de splicing (KIS) em processos celulares relacionados à leucemogênese. 2016. Dissertação (Mestrado) -